Výsledky vyhledávání - "MESH: Hedgehog Proteins"

A Homozygous Missense Variant in Hedgehog Acyltransferase (HHAT) Gene Associated with 46,XY Gonadal Dysgenesis

Autor: Inas, Mazen, Alaa, Kamel, Kenneth, McElreavey, Anu, Bashamboo, Aya, Elaidy, Mohamed S, Abdel-Hamid

Publikováno v: Sexual Development
Sexual Development, 2023, 16 (4), pp.261-265. ⟨10.1159/000520366⟩

International audience; Introduction: Disorders of gonadal development represent a clinically and genetically heterogeneous group of DSD, and the etiology in many cases remains unknown, indicating that our knowledge of factors controlling sex determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22cf34d7caa2540c4e27bf83982cd00e
https://hal.science/hal-04150451

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Safety and efficacy of nivolumab, an anti-PD1 immunotherapy, in patients with advanced basal cell carcinoma, after failure or intolerance to sonic Hedgehog inhibitors: UNICANCER AcSé NIVOLUMAB trial

Publikováno v: European Journal of Cancer
European Journal of Cancer, 2022, 177, pp.103-111. ⟨10.1016/j.ejca.2022.09.013⟩

International audience; Basal cell carcinoma (BCC) is the most common human malignancy. In most cases, BCC has slow progression and can be definitively cured by surgery or radiotherapy. However, in rare cases, it can become locally advanced or, even

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e3fce35e724bd71f86e03f3346c539
https://pubmed.ncbi.nlm.nih.gov/36335780

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Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

Autor: Maurizio Taddei, Alessandra Chiarenza, Elena Petricci, Fabrizio Manetti, Antonella Naldini, Martial Ruat, Fabio Carraro

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (3), pp.e0149919. ⟨10.1371/journal.pone.0149919⟩
PLoS ONE, Vol 11, Iss 3, p e0149919 (2016)

International audience; The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient's life expect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cadb6ef80e4df9284bc953bdb80b288
https://hal.archives-ouvertes.fr/hal-01366756

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Stability study of the human G-protein coupled receptor, Smoothened

Autor: Bernard Pucci, Michel Bidet, Isabelle Mus-Veteau, Ange Polidori, Olivier Joubert, Benoît Lacombe, Rony Nehmé

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2010, 1798 (6), pp.1100-10. ⟨10.1016/j.bbamem.2010.02.015⟩

International audience; Smoothened is a member of the G-protein coupled receptor (GPCR) family responsible for the transduction of the Hedgehog signal to the intracellular effectors of the Hedgehog signaling pathway. Aberrant regulation of this recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a12b3ec4296e7465a7159df192ac71

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Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis

Autor: François Guillemot, Isabelle Le Roux, Vanessa Ribes, Pascal Dollé, Laurent Bianchetti, Fanny Stutzmann

Publikováno v: Developmental Biology
Developmental Biology, Elsevier, 2008, 321 (2), pp.470-81. ⟨10.1016/j.ydbio.2008.06.003⟩
Developmental Biology, 2008, 321 (2), pp.470-81. ⟨10.1016/j.ydbio.2008.06.003⟩

International audience; A central issue during embryonic development is to define how different signals cooperate in generating unique cell types. To address this issue, we focused on the function and the regulation of the proneural gene Neurogenin2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0d82ad6afa73f253dc0a2e03dfedec
https://doi.org/10.1016/j.ydbio.2008.06.003

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Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials

Autor: Elisabeth Dupin, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, Giordano W. Calloni

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (50), pp.19879-84. ⟨10.1073/pnas.0708806104⟩
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (50), pp.19879-84. ⟨10.1073/pnas.0708806104⟩

In the vertebrate embryo, the cephalic neural crest cells (CNCCs) produce cells belonging to two main lineages: the neural [including neurons, glial cells of the peripheral nervous system (PNS), and melanocytes] and the mesenchymal (chondrocytes, ost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df84ae0c743ba882eac7835770ba133e
https://doi.org/10.1073/pnas.0708806104

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Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

Autor: Arnaud Truchi, Laurent Ruel, Sophie Raisin, Alexandra Cervantes, Pascal P. Thérond, Laurence Staccini-Lavenant, Armel Gallet

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2007, 134 (20), pp.3677-89. ⟨10.1242/dev.011577⟩

The Hedgehog (Hh) family of secreted proteins is involved both in developmental and tumorigenic processes. Although many members of this important pathway are known, the mechanism of Hh signal transduction is still poorly understood. In this study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb9e11f0d757a28a93eff4325baddb5
https://doi.org/10.1242/dev.011577

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Developmental biology: Hedgehog turns into a metabolic hormone

Autor: Neha Agrawal, Pierre Léopold

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2015, 25 (3), pp.R117-9

Rodenfels et al. show that the Drosophila intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f758fdd840da9505ed440f492219fe0
https://pubmed.ncbi.nlm.nih.gov/25452274

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Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling

Autor: Gisela D'Angelo, Pascal P. Thérond, Sandrine Pizette, Tamás Matusek

Publikováno v: Developmental Cell
Developmental Cell, 2015, 32 (3), pp.290-303. ⟨10.1016/j.devcel.2014.12.004⟩
Developmental Cell, Elsevier, 2015, 32 (3), pp.290-303. ⟨10.1016/j.devcel.2014.12.004⟩
HAL
Developmental Cell, Elsevier, 2015, 32 (3), pp.290-303

International audience; The proteins of the Hedgehog (Hh) family are secreted proteins exerting short- and long-range control over various cell fates in developmental patterning. The Hh gradient in Drosophila wing imaginal discs consists of apical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d273f5ec149f9754305bb8b65073ae4a
https://hal.science/hal-03033949

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The primary cilium undergoes dynamic size modifications during adipocyte differentiation of human adipose stem cells

Autor: Sandra Lacas-Gervais, Pascal Peraldi, Nicolas Forcioli-Conti, Christian Dani

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2015, 458 (1), pp.117-22

International audience; The primary cilium is an organelle present in most of the cells of the organism. Ciliopathies are genetic disorders of the primary cilium and can be associated with obesity. We have studied the primary cilium during adipocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f755629c7c97dc954667f3410c9ac47
https://pubmed.ncbi.nlm.nih.gov/25637533

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