Výsledky vyhledávání - "MESH: HIV-1/physiology"

SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV

Autor: Francesca Di Nunzio, Olivier Schwartz, Françoise Porrot, Felipe Diaz-Griffero, Sonia Amraoui, Silvana Opp, Daniel A. Donahue, Camille Kieffer, Nicoletta Casartelli

Publikováno v: Journal of Virology
Journal of Virology, 2016, 90 (8), pp.4199-4214. ⟨10.1128/JVI.03202-15⟩
Journal of Virology, American Society for Microbiology, 2016, 90 (8), pp.4199-4214. ⟨10.1128/JVI.03202-15⟩

In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. SUN2 is an inner nuclear membrane protein belonging to the linker of nucleoskeleton and cytoskeleton complex. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe5771f97b8d11016b24524523e619
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372386

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Actin’ on HIV: How Dendritic Cells Spread Infection

Autor: Daniel A. Donahue, Olivier Schwartz

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2016, 19 (3), pp.267-269. ⟨10.1016/j.chom.2016.02.016⟩
Cell Host and Microbe, 2016, 19 (3), pp.267-269. ⟨10.1016/j.chom.2016.02.016⟩

Whereas human dendritic cells (DCs) are largely resistant to productive infection with HIV-1, they have a unique ability to take up the virus and transmit it efficiently to T lymphocytes through a process of trans-infection or trans-enhancement. To e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc223c460f63b9a8d19d4c8e9d0288d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372388

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SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells

Autor: Olivier Schwartz, Françoise Porrot, Nicoletta Casartelli, Isabel Puigdomenech

Publikováno v: Journal of Virology
Journal of Virology, 2013, 87 (5), pp.2846-56. ⟨10.1128/JVI.02514-12⟩
Journal of Virology, American Society for Microbiology, 2013, 87 (5), pp.2846-56. ⟨10.1128/JVI.02514-12⟩

SAMHD1 is a viral restriction factor expressed in dendritic cells and other cells, inhibiting infection by cell-free human immunodeficiency virus type 1 (HIV-1) particles. SAMHD1 depletes the intracellular pool of deoxynucleoside triphosphates, thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed39bfea2b21535d59b7357677ab8d8
https://hal-pasteur.archives-ouvertes.fr/pasteur-01109474

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Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort

Autor: Linda, Wittkop, Juliette, Bitard, Estibaliz, Lazaro, Didier, Neau, Fabrice, Bonnet, Patrick, Mercie, Michel, Dupon, Mojgan, Hessamfar, Michel, Ventura, Denis, Malvy, François, Dabis, Jean-Luc, Pellegrin, Jean-François, Moreau, Rodolphe, Thiébaut, Isabelle, Pellegrin, D, Touchard

Publikováno v: The Internet Journal of Infectious Diseases
The Internet Journal of Infectious Diseases, Internet Scientific Publications, LLC, 2013, 207, pp.622-7
Journal of Infectious Diseases
Journal of Infectious Diseases, 2013, 207 (4), pp.622-7. ⟨10.1093/infdis/jis732⟩
The Internet Journal of Infectious Diseases, 2013, 207, pp.622-7

International audience; We evaluated the impact of cytomegalovirus (CMV)-induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1-infected patients from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1ca0d58a4e522c9a8ba04b7584b6b8
https://hal.archives-ouvertes.fr/hal-01101196

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Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

Publikováno v: Journal of Experimental Medicine; Vol 208
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2011, 208 (9), pp.1823-1834. ⟨10.1084/jem.20101805⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2011, 208 (9), pp.1823-1834. ⟨10.1084/jem.20101805⟩

Contact with HIV-1 envelope protein elicits release of ATP through pannexin-1 channels on target cells; by activating purinergic receptors and Pyk2 kinase in target cells, this extracellular ATP boosts HIV-1 infectivity.
Extracellular adenosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8255f06ecca1664b78c8748ed44621
http://hdl.handle.net/2108/19411

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Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

Autor: Victor Appay, Jorge R. Almeida, Brigitte Autran, Daniel C. Douek, Gianfranco Pancino, Arnaud Moris, David Price, So Youn Shin, Martin Larsen, Delphine Sauce, Asier Sáez-Cirión, Laura Papagno

Publikováno v: Blood
Blood, American Society of Hematology, 2009, 113 (25), pp.6351-6360. ⟨10.1182/blood-2009-02-206557⟩
ResearcherID
Blood, 2009, 113 (25), pp.6351-6360. ⟨10.1182/blood-2009-02-206557⟩

CD8+ T cells are major players in the immune response against HIV. However, recent failures in the development of T cell–based vaccines against HIV-1 have emphasized the need to reassess our basic knowledge of T cell–mediated efficacy. CD8+ T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277ef4f5b7f8025dc25aa5552091b4ef
https://hal.archives-ouvertes.fr/hal-02455368

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