Výsledky vyhledávání - "MESH: HCT116 Cells"

Listeria monocytogenesexploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection

Autor: Mariette Matondo, Pascale Cossart, Filipe Carvalho, Fabrizia Stavru, Anna Spier, T. Chaze

Publikováno v: mBio
mBio, American Society for Microbiology, 2020, 11 (1), ⟨10.1128/mBio.03171-19⟩
mBio, 2020, 11 (1), ⟨10.1128/mBio.03171-19⟩

Mitochondrial function adapts to cellular demands and is affected by the ability of the organelle to undergo fusion and fission in response to physiological and non-physiological cues. We previously showed that infection with the human bacterial path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e9e3457ca897166d9cfa7bbc722cc9
https://doi.org/10.1101/712067

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The Cytotoxic Effect of Apis mellifera Venom with a Synergistic Potential of Its Two Main Components—Melittin and PLA2—On Colon Cancer HCT116 Cell Lines

Autor: Ziad Fajloun, Bruno Coutard, Dany El-Obeid, Jean-Marc Sabatier, Mariam Rifi, Carole Yaacoub, Hiba Mawlawi

Publikováno v: Molecules
Volume 26
Issue 8
Molecules, MDPI, 2021, 26 (8), pp.2264. ⟨10.3390/molecules26082264⟩
Molecules, Vol 26, Iss 2264, p 2264 (2021)
Molecules, 2021, 26 (8), pp.2264. ⟨10.3390/molecules26082264⟩

Colon carcinogenesis is ranked second globally among human diseases after cardiovascular failures. Bee venom (BV) has been shown to possess in vitro anticancer effects against several types of cancer cells. The two main biopeptides of Apis mellifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950177cde97e1d10ed963e499e3a5d15
https://doi.org/10.3390/molecules26082264

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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2016, 62 (1), pp.121-136. ⟨10.1016/j.molcel.2016.02.005⟩

Comment in : A Billion Ubiquitin Variants to Probe and Modulate the UPS. [Mol Cell. 2016]; International audience; HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process and are misregulated in numerous d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0423280b3710b384d45c649c83c073
https://doi.org/10.1016/j.molcel.2016.02.005

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SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling

Autor: Muriel Busson, Lucile Canterel-Thouennon, Corinne Prévostel, Helene Trauchessec, Philippe Blache, Marc Ychou, Cyrine Rammah-Bouazza

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2016, 7 (50), pp.82228-82243. ⟨10.18632/oncotarget.10573⟩

International audience; SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactiva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c4b6af24b216b9fbd2a3480b34f92d
https://hal.umontpellier.fr/hal-02298842/document

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Rearranged Diterpenoids from the Biotransformation of ent-Trachyloban-18-oic Acid by Rhizopus arrhizus

Autor: Françoise Guéritte, Marc Litaudon, Jamal Ouazzani, Mat Ropi Mukhtar, Claudine Servy, Pascal Retailleau, Khalijah Awang, Marie-Thérèse Martin, Aurélie Leverrier

Publikováno v: Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2010, 73 (6), pp.1121-5. ⟨10.1021/np100145n⟩

International audience; In our search for inhibitors of the antiapoptotic protein Bcl-xL, investigation of Xylopia caudata afforded a new diterpenoid, ent-trachyloban-4beta-ol (2), and five known ent-trachylobane or ent-atisane compounds. Only ent-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58defbf46cf1a325af6900d8cb42581f
https://doi.org/10.1021/np100145n

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Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect

Autor: Olivier Loréal, Martine Ropert, François Gaboriau, Sylvie Lepage, Vincent Corcé, Isabelle Cannie, David Deniaud, Stéphanie Renaud

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩
Biochemical Pharmacology, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩

International audience; Tumor cell growth requires large iron quantities and the deprivation of this metal induced by synthetic metal chelators is therefore an attractive method for limiting the cancer cell proliferation. The antiproliferative effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8eaeacdc2a079dd88d9dcdf99544b
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163245/document

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A Novel Cell Cycle Inhibitor Stalls Replication Forks and Activates S Phase Checkpoint

Autor: Kai Lee Yap, Anthony Ting, Tiffany Siew Joo Lim, Vaidehi Krishnan, Etienne Schwob, Chee Seng Cheng, Léon Dirick, Hong Hwa Lim, Uttam Surana, San Ling Si-Hoe

Publikováno v: Cell Cycle
Cell Cycle, Taylor & Francis, 2014, 6 (13), pp.1621-1630. ⟨10.4161/cc.6.13.4373⟩
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International audience; DNA replication checkpoint is activated in response to replication stresses. It maintains the integrity of stalled replication forks and prevents premature segregation of largely unreplicated chromosomes. In budding yeast, Mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac08ee66d5cf6a6e796354277e76585
https://hal.archives-ouvertes.fr/hal-03044284

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Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.: Sorafenib inhibits ABCG2 and overcome irinotecan resistance

Autor: Mazard, Thibault, Causse, Annick, Simony, Joelle, Leconet, Wilhem, Vezzio-Vie, Nadia, Torro, Adeline, Jarlier, Marta, Evrard, Alexandre, Del Rio, Maguy, Assenat, Eric, Martineau, Pierre, Ychou, Marc, Robert, Bruno, Gongora, Celine

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2013, 12 (10), pp.2121-34. ⟨10.1158/1535-7163.MCT-12-0966⟩

International audience; Despite recent advances in the treatment of colorectal cancer (CRC), tumor resistance is a frequent cause of chemotherapy failure. Therefore, new treatment options are needed to improve survival of patients with irinotecan-ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c4ce7a3ac97bd42c8a2db209d6dae01d
https://www.hal.inserm.fr/inserm-00861055

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Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.: Sorafenib inhibits ABCG2 and overcome irinotecan resistance

Autor: Mazard, Thibault, Causse, Annick, Simony, Joelle, Leconet, Wilhem, Vezzio-Vie, Nadia, Torro, Adeline, Jarlier, Marta, Evrard, Alexandre, del Rio, Maguy, Assenat, Eric, Martineau, Pierre, Ychou, Marc, Robert, Bruno, Gongora, Celine

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2013, 12 (10), pp.2121-34. ⟨10.1158/1535-7163.MCT-12-0966⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::c4ce7a3ac97bd42c8a2db209d6dae01d
https://www.hal.inserm.fr/inserm-00861055

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