Výsledky vyhledávání - "MESH: Glycogen Synthase Kinase 3"

Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors

Autor: Jessica Bertrand, Bernard Payrastre, N Gallay, Nathalie Vergnolle, Véronique Maguer-Satta, Mathieu Despeaux, Cécile Demur, Ezzeddine Bourogaa, S Joly, P Bonnevialle, F Louache, Claire Racaud-Sultan

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2012, 31 (6), pp.694-705. 〈10.1038/onc.2011.258〉
Oncogene, Nature Publishing Group, 2012, 31 (6), pp.694-705. ⟨10.1038/onc.2011.258⟩

International audience; Therapeutic resistance of acute myeloid leukemia stem cells, enriched in the CD34(+)38(-)123(+) progenitor population, is supported by extrinsic factors such as the bone marrow niche. Here, we report that when adherent onto fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d4a2f208c4080faac4382098e8472e
https://doi.org/10.1038/onc.2011.258

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β-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding Sites

Autor: Lucie M. Laqueuvre, Eliette Bonnefoy, Charbel Massaad, Zeyni Mansuroglu, Jean-Jacques Panthier, Lionel Luron, Dominique Simon, Vasco Marcato, Sylvie Souès, Marie Flamand

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2015, 36 (1), pp.13-29. 〈10.1128/MCB.00641-15〉
Molecular and Cellular Biology, 2015, 36 (1), pp.13-29. ⟨10.1128/MCB.00641-15⟩
Molecular and Cellular Biology, American Society for Microbiology, 2015, 36 (1), pp.13-29. ⟨10.1128/MCB.00641-15⟩

International audience; Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de58f6cc50639a4f68eb49badc44a8eb
https://hal-pasteur.archives-ouvertes.fr/pasteur-01326511

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Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation

Autor: Guido Kroemer, Cécile Martel, Céline Henry, Catherine Brenner, Elena Fanelli, Maya Allouche, Joël Chopineau, Giuseppe Calamita, Davide Degli Esposti, Antoinette Lemoine, Céline Boursier

Publikováno v: Hepatology
Hepatology, 2013, 57 (1), pp.93-102. ⟨10.1002/hep.25967⟩
Hepatology, Wiley-Blackwell, 2013, 57 (1), pp.93-102. 〈10.1002/hep.25967〉
Hepatology, Wiley-Blackwell, 2013, 57 (1), pp.93-102. ⟨10.1002/hep.25967⟩

International audience; UNLABELLED: Nonalcoholic steatosis is a liver pathology characterized by fat accumulation and severe metabolic alterations involving early mitochondrial impairment and late hepatocyte cell death. However, mitochondrial dysfunc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e302b73b0ab87dc4669ac9bcabb187
https://hal.science/hal-00734262

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Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Autor: Anne Beauchard, Olivier Lozach, Thierry Besson, Laurent Meijer, Mélina Blairvacq, Valérie Thiéry, Yoan Ferandin, Stéphane Frère

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d965ae963876b84e60cc84b3e8b79b7
https://doi.org/10.1016/j.bmc.2006.05.036

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7-Bromoindirubin-3′-oxime induces caspase-independent cell death

Autor: Jacint Boix, Karima Bettayeb, Frank Totzke, Alexios-Leandros Skaltsounis, Jan Mester, Xènia Garrofé-Ochoa, Laurent Meijer, Panos Polychronopoulos, Yoan Ferandin, Prokopios Magiatis, Judit Ribas, Marie Knockaert, Christoph Schächtele

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (47), pp.6304-18. ⟨10.1038/sj.onc.1209648⟩
Recercat. Dipósit de la Recerca de Catalunya
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Oncogene, 2006, 25 (47), pp.6304-18. ⟨10.1038/sj.onc.1209648⟩

Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ingredient of a traditional Chines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5905aba6a45aa9ccd7ee5d0dd9704b32
https://doi.org/10.1038/sj.onc.1209648

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Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C-tail Revealed by NMR

Autor: Elouan Terrien, Muriel Delepierre, Alain Chaffotte, Nicolas Wolff, Christophe Prehaud, François-Xavier Theillet, Henri Buc, Monique Lafon, Florence Cordier

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩
Journal of the American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩

International audience; PTEN phosphatase is a tumor suppressor controlling notably cell growth, proliferation and survival. The multisite phosphorylation of the PTEN C-terminal tail regulates PTEN activity and intracellular trafficking. The dynamical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30175c6e029540b496c167343fd6370
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883989

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A protocol to quantify mammary early common progenitors from long-term mammosphere culture

Autor: Véronique Maguer-Satta, Emmanuel Delay, Elodie Bachelard-Cascales, Marion Chapellier

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2012, Chapter 1 (6), pp.Unit 1E.7. ⟨10.1002/9780470151808.sc01e07s20⟩
Current Protocols in Stem Cell Biology
Oncogene, Nature Publishing Group, 2012, Chapter 1 (6), pp.Unit 1E.7. 〈10.1002/9780470151808.sc01e07s20〉

International audience; Here we describe a protocol established in our laboratory to quantify early common progenitors/stem cells grown as spheres in non-adherent culture conditions. This protocol is based on the combination of two functional tests:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2d204d6a47c3e2310839cf19a39d41
https://hal.archives-ouvertes.fr/hal-00723479

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Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3

Autor: Vincenzo Federico, Maria Rosaria Ricciardi, Alessandra Soriani, Cinzia Fionda, Marco Cippitelli, Angela Santoni, Maria Teresa Petrucci, Alessandra Zingoni, Francesca Cecere, Maria Luisa Iannitto, Giulia Malgarini

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2013, 190 (12), pp.6662-72. ⟨10.4049/jimmunol.1201426⟩

Engagement of NKG2D and DNAX accessory molecule-1 (DNAM-1) receptors on lymphocytes plays an important role for anticancer response and represents an interesting therapeutic target for pharmacological modulation. In this study, we investigated the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a210298ba8e87bb8875dab2e4583bd
https://hal-riip.archives-ouvertes.fr/pasteur-01054147

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Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds

Autor: Carmen Gil, Pablo D. Dans, Ana Martínez, F. Javier Luque, Santiago Conde, Concepción Pérez, Valle Palomo, Daniel I. Perez

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2011, 54 (12), pp.4042-56. ⟨10.1021/jm1016279⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, being one of the inhibitors on clinical trials for dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92abbaadba245808bf2575ecb396976a
https://hal-riip.archives-ouvertes.fr/pasteur-00686303

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