Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Autor: David E. James, Benjamin L. Parker, Jesper B. Birk, Lea Bruhn, Marie F. Rosschou, Nils J. Færgeman, Kei Sakamoto, Joachim Fentz, Mads B. Hansen, Erik A. Richter, Bente Kiens, Marc Foretz, Jørgen F. P. Wojtaszewski, Janne R. Hingst, Jesper F. Havelund, Benoit Viollet, Jørgen Arendt Jensen

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2018, 16, pp.24-34. ⟨10.1016/j.molmet.2018.07.001⟩
Molecular Metabolism, Vol 16, Iss, Pp 24-34 (2018)
Hingst, J R, Bruhn, L, Hansen, M B, Rosschou, M F, Birk, J B, Fentz, J, Foretz, M, Viollet, B, Sakamoto, K, Færgeman, N J, Havelund, J F, Parker, B L, James, D E, Kiens, B, Richter, E A, Jensen, J & Wojtaszewski, J F P 2018, ' Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle ', Molecular Metabolism, vol. 16, pp. 24-34 . https://doi.org/10.1016/j.molmet.2018.07.001
Hingst, J R, Bruhn, L, Hansen, M B, Rosschou, M F, Birk, J B, Fentz, J, Foretz, M, Viollet, B, Sakamoto, K, Færgeman, N J, Havelund, J F, Parker, B L, James, D E, Kiens, B, Richter, E A, Jensen, J & Wojtaszewski, J 2018, ' Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle ', Molecular Metabolism, vol. 16, pp. 24-34 . https://doi.org/10.1016/j.molmet.2018.07.001

Objective: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8ecdbb54702daeab6b41d68b7fb54
https://hal.archives-ouvertes.fr/hal-02348845

β-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding Sites

Autor: Lucie M. Laqueuvre, Eliette Bonnefoy, Charbel Massaad, Zeyni Mansuroglu, Jean-Jacques Panthier, Lionel Luron, Dominique Simon, Vasco Marcato, Sylvie Souès, Marie Flamand

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2015, 36 (1), pp.13-29. 〈10.1128/MCB.00641-15〉
Molecular and Cellular Biology, 2015, 36 (1), pp.13-29. ⟨10.1128/MCB.00641-15⟩
Molecular and Cellular Biology, American Society for Microbiology, 2015, 36 (1), pp.13-29. ⟨10.1128/MCB.00641-15⟩

International audience; Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de58f6cc50639a4f68eb49badc44a8eb
https://hal-pasteur.archives-ouvertes.fr/pasteur-01326511

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Autor: Anne Beauchard, Olivier Lozach, Thierry Besson, Laurent Meijer, Mélina Blairvacq, Valérie Thiéry, Yoan Ferandin, Stéphane Frère

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d965ae963876b84e60cc84b3e8b79b7
https://doi.org/10.1016/j.bmc.2006.05.036

Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C-tail Revealed by NMR

Autor: Elouan Terrien, Muriel Delepierre, Alain Chaffotte, Nicolas Wolff, Christophe Prehaud, François-Xavier Theillet, Henri Buc, Monique Lafon, Florence Cordier

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩
Journal of the American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩

International audience; PTEN phosphatase is a tumor suppressor controlling notably cell growth, proliferation and survival. The multisite phosphorylation of the PTEN C-terminal tail regulates PTEN activity and intracellular trafficking. The dynamical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30175c6e029540b496c167343fd6370
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883989

Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors

Autor: Mandard, Stéphane, Stienstra, Rinke, Escher, Pascal, Tan, Nguan Soon, Kim, Insook, Gonzalez, Frank, Wahli, Walter, Desvergne, Béatrice, Müller, Michael, Kersten, Sander

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2007, 64 (9), pp.1145-57. 〈10.1007/s00018-007-7006-1〉
Cellular and Molecular Life Sciences, Springer Verlag, 2007, 64 (9), pp.1145-57. ⟨10.1007/s00018-007-7006-1⟩

International audience; Glycogen synthase 2 (Gys-2) is the ratelimiting enzyme in the storage of glycogen in liver and adipose tissue, yet little is known about regulation of Gys-2 transcription. The peroxisome proliferator-activated receptors (PPARs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c84b62cefc894f77e879ee2e106c58ab
http://www.hal.inserm.fr/inserm-00495971/file/Mandard_S_Cell_Mol_Life_Sci_2007_PPARs_and_Gys-2_.pdf