Distinct proteomic features of two fibrogenic liver cell populations: hepatic stellate cells and portal myofibroblasts

Autor: Michel Vaubourdolle, Thorsten Burmester, Joëlle Vinh, Paulo Marcelo, Nelly Bosselut, Axelle Cadoret, Bruno Baudin, Chantal Housset, Colette Rey

Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2010, 10 (5), pp.1017-28. ⟨10.1002/pmic.200900257⟩

International audience; In chronic liver diseases, the accumulation of extracellular matrix leading to fibrosis is caused by myofibroblasts, the origins of which are debatable. We performed a comparative proteomic study to identify markers and gain i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55071627a1da32736adc0567200719b2
https://hal.archives-ouvertes.fr/hal-00539861

Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties

Autor: Eva Geuens, Angela Fago, Martino Bolognesi, Michael C. Marden, Laurent Kiger, Evi Vinck, L. Tilleman, Sabine Van Doorslaer, Alessandra Pesce, David Hoogewijs, Roy E. Weber, Marco Nardini, Sasha De Henau, Jacques R. Vanfleteren, Luc Moens, Sylvia Dewilde

Publikováno v: BMC Biochemistry
BMC Biochemistry, 2010, 11 (1), pp.17. ⟨10.1186/1471-2091-11-17⟩
BMC Biochemistry, BioMed Central, 2010, 11 (1), pp.17. ⟨10.1186/1471-2091-11-17⟩
Geuens, E, Hoogewijs, D, Nardini, M, Vinck, E, Pesce, A, Kiger, L, Fago, A, Tilleman, L, De Henau, S, Marden, M C, Weber, R E, Van Doorslaer, S, Vanfleteren, J, Moens, L, Bolognesi, M & Dewilde, S 2010, ' Globin-like proteins in Caenorhabditis elegans : in vivo localization, ligand binding and structural properties ', B M C Biochemistry, vol. 11, pp. 17 . https://doi.org/10.1186/1471-2091-11-17
Aarhus University
BMC Biochemistry, Vol 11, Iss 1, p 17 (2010)
BMC biochemistry

Background The genome of the nematode Caenorhabditis elegans contains more than 30 putative globin genes that all are transcribed. Although their translated amino acid sequences fit the globin fold, a variety of amino-acid substitutions and extension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b0b9d725063b6ec64b823f665cc338
https://www.hal.inserm.fr/inserm-00615497/document

Oculocutaneous albinism type 2 (OCA2) with homozygous 2.7-kb deletion of the P gene and sickle cell disease in a Cameroonian family. Identification of a common TAG haplotype in the mutated P gene

Autor: Frédéric Austerlitz, Catherine Badens, Robert Aquaron, Bernard Grandchamp, Jean-louis Bergé-Lefranc, Nadem Soufir

Publikováno v: Journal of Human Genetics
Journal of Human Genetics, 2007, 52 (9), pp.771-80. ⟨10.1007/s10038-007-0181-y⟩
Journal of Human Genetics, Nature Publishing Group, 2007, 52 (9), pp.771-80. ⟨10.1007/s10038-007-0181-y⟩

International audience; In this study, we report on a Cameroonian family from the Ewondo ethnic group, presenting with three oculocutaneous albinism type 2 (OCA2) patients homozygous for the 2.7-kb deletion of the P gene. In one of these patients OCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4caa8b91f0f9f798495abf9c0f279f5e
https://hal.science/hal-00531089

Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs

Autor: Hinrich Gronemeyer, Beatriz Iglesias, Claudine Gaudon, Pierre Germain, Angel R. de Lera, Raquel Pereira

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 16 (1), pp.49-54. ⟨10.1016/j.bmcl.2005.09.060⟩

Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARbeta/delta agonist yet described, and equally selective analogs at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205279b27b086bab7be0d578cde6810b
https://hal.archives-ouvertes.fr/hal-00188105

The beta-globin HS4 insulator confers copy-number dependent expression of IgH regulatory elements in stable B cell transfectants

Autor: Michel Cogné, Laurence Guglielmi, Yves Denizot, Véronique Truffinet

Publikováno v: Immunology Letters
Immunology Letters, Elsevier, 2003, 89 (2-3), pp.119-23. ⟨10.1016/S0165-2478(03)00126-3⟩

Locus control regions (LCR) were first defined by their theoretical ability to enhance the expression of linked genes in a tissue-specific, position-independent and copy-number dependent manner. In fact, few of the so-called LCR identified completely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c79f0e6920ac8298fa5909a90b860f0
https://pubmed.ncbi.nlm.nih.gov/15585338