Výsledky vyhledávání - "MESH: Genomics / methods"

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

Autor: Isabelle P. Oswald, Emilien L. Jamin, Thaïs Hautbergue, Olivier Puel, Laurent Debrauwer

Publikováno v: Natural Product Reports
Natural Product Reports, Royal Society of Chemistry, 2018, 35 (2), pp.147-173. ⟨10.1039/c7np00032d⟩
Natural Product Reports, 2018, 35 (2), pp.147-173. ⟨10.1039/c7np00032d⟩

International audience; Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of the fungus to its environment. Although some of these natural products are promising sources of new lead compounds especially for the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488311aeb48b0d66affe18db74ac609d
https://doi.org/10.1039/c7np00032d

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More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Autor: Gordon Dougan, Ana Elena Pérez-Cobas, Christophe Rusniok, Sandra Reuter, Carmen Buchrieser, Jasmin Demirtas, Shivani Pasricha, Elizabeth L. Hartland, Gunnar N. Schroeder, Gad Frankel, S. Jarraud, Sonia Mondino, Laura Gomez-Valero, Johannes Crumbach, Monica Rolando, Stéphane Descorps-Declère, Danielle Carson

Publikováno v: Gomez-Valero, L, Rusniok, C, Carson, D, Mondino, S, Pérez-Cobas, A E, Rolando, M, Pasricha, S, Reuter, S, Demirtas, J, Crumbach, J, Descorps-Declere, S, Hartland, E L, Jarraud, S, Dougan, G, Schroeder, G N, Frankel, G & Buchrieser, C 2019, ' More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1808016116, https://doi.org/10.1101/350777
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.2265-2273. ⟨10.1073/pnas.1808016116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.2265-2273. ⟨10.1073/pnas.1808016116⟩

The genus Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally analyzed 80 Legionella g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c453963aa5d05c45e4f3bbed371caec
https://pure.qub.ac.uk/en/publications/more-than-18000-effectors-in-the-legionella-genus-genome-provide-multiple-independent-combinations-for-replication-in-human-cells(8cb35736-8923-4ed6-920d-e29c42f7d390).html

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Development of Bioinformatics Infrastructure for Genomics Research

Publikováno v: Global Heart; Vol 12, No 2 (2017); 91-98
Global Heart
Global Heart, World Heart Federation, 2017, 12 (2), pp.91-98. ⟨10.1016/j.gheart.2017.01.005⟩

Background: Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212de5789d93841ce86521a5e6ef2002
https://doi.org/10.1016/j.gheart.2017.01.005

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Filling annotation gaps in yeast genomes using genome-wide contact maps

Autor: Gilles Fischer, Martial Marbouty, Gianni Liti, Christophe Zimmer, Hervé Marie-Nelly, Axel Cournac, Romain Koszul

Publikováno v: Bioinformatics
Bioinformatics, 2014, 30 (15), pp.2105-13. ⟨10.1093/bioinformatics/btu162⟩
Bioinformatics, Oxford University Press (OUP), 2014, 30 (15), pp.2105-13. ⟨10.1093/bioinformatics/btu162⟩

Motivations: De novo sequencing of genomes is followed by annotation analyses aiming at identifying functional genomic features such as genes, non-coding RNAs or regulatory sequences, taking advantage of diverse datasets. These steps sometimes fail a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7b4bbf8646c7250eb5442990dae88c

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COV2HTML: A Visualization and Analysis Tool of Bacterial Next Generation Sequencing (NGS) Data for Postgenomics Life Scientists

Autor: Emilie Camiade, Clément Brehier, Marc Monot, Mickael Orgeur, Bruno Dupuy

Publikováno v: OMICS
OMICS, Mary Ann Liebert, 2014, 18 (3), pp.184-195. ⟨10.1089/omi.2013.0119⟩
OMICS, 2014, 18 (3), pp.184-195. ⟨10.1089/omi.2013.0119⟩

International audience; COV2HTML is an interactive web interface, which is addressed to biologists, and allows performing both coverage visualization and analysis of NGS alignments performed on prokaryotic organisms (bacteria and phages). It combines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a744c71e5821e2c8e2721f17a0311b
https://europepmc.org/articles/PMC3934542/

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GLADX: an automated approach to analyze the lineage-specific loss and pseudogenization of genes

Autor: Dainat, Jacques, Paganini, Julien, Pontarotti, Pierre, Gouret, Philippe

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e38792. ⟨10.1371/journal.pone.0038792⟩
PLoS ONE, Vol 7, Iss 6, p e38792 (2012)
PLoS ONE, 2012, 7 (6), pp.e38792. ⟨10.1371/journal.pone.0038792⟩

International audience; A well-established ancestral gene can usually be found, in one or multiple copies, in different descendant species. Sometimes during the course of evolution, all the representatives of a well-established ancestral gene disappe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1ecfe296efdcd14c4b62ed09e2551d02
https://hal.archives-ouvertes.fr/hal-00831091

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