Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Autor: Verena Königer, D. Scott Merrell, Roman Andriiovych Moskalenko, Rainer Haas, Thomas Borén, Sara Henriksson, Jafar Mahdavi, Abhijit Chowdhury, Johan Ögren, Anders Hofer, Jay V. Solnick, Dan Danielsson, Sara K. Lindén, Dag Ilver, Konstantinos S. Papadakos, Susanne Vikström, Jörgen Ådén, Jan Holgersson, Gerhard Gröbner, Alexej Schmidt, Jeanna Bugaytsova, Oscar Björnham, Göran O. Bylund, Rolf Sjöström, Stefan Oscarson, Dionyssios N. Sgouras, Lori M. Hansen, Yevgen A Chernov, Anders Esberg, Kristof Moonens, Christopher Aisenbrey, Charles Kelly, Ludmilla A. Morozova-Roche, Jeannette M. Whitmire, Beatriz Martinez-Gonzalez, Asish K. Mukhopadhyay, Angela Eldridge, Nicklas Strömberg, Robert H. Gilman, Andre Dubois, Lars Engstrand, Staffan Schedin, Brett A. Chromy, Justine Younson, Matthew Goldman, Anna Shevtsova, Macarena P. Quintana-Hayashi, Hui Liu, Magnus Unemo, Lena Rakhimova, Anna Åberg, Sebastian Suerbaum, Anna Arnqvist, Pär Gideonsson, Maréne Landström, Douglas E. Berg, Kristoffer Brännström, Anders Olofsson, Melissa Mendez, G. Balakrish Nair, Han Remaut

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2017, 21 (3), pp.376-389. ⟨10.1016/j.chom.2017.02.013⟩
Cell host & microbe, vol 21, iss 3
Bugaytsova, J A, Björnham, O, Chernov, Y A, Gideonsson, P, Henriksson, S, Mendez, M, Sjöström, R, Mahdavi, J, Shevtsova, A, Ilver, D, Moonens, K, Quintana-Hayashi, M P, Moskalenko, R, Aisenbrey, C, Bylund, G, Schmidt, A, Åberg, A, Brännström, K, Königer, V, Vikström, S, Rakhimova, L, Hofer, A, Ögren, J, Liu, H, Goldman, M D, Whitmire, J M, Ådén, J, Younson, J, Kelly, C G, Gilman, R H, Chowdhury, A, Mukhopadhyay, A K, Nair, G B, Papadakos, K S, Martinez-Gonzalez, B, Sgouras, D N, Engstrand, L, Unemo, M, Danielsson, D, Suerbaum, S, Oscarson, S, Morozova-Roche, L A, Olofsson, A, Gröbner, G, Holgersson, J, Esberg, A, Strömberg, N, Landström, M, Eldridge, A M, Chromy, B A, Hansen, L M, Solnick, J V, Lindén, S K, Haas, R, Dubois, A, Merrell, D S, Schedin, S, Remaut, H, Arnqvist, A, Berg, D E & Borén, T 2017, ' Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence ', Cell Host & Microbe, vol. 21, no. 3, pp. 376-389 . https://doi.org/10.1016/j.chom.2017.02.013

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a43b410aab75acc08a9fa79a43ec0bb
https://hal-riip.archives-ouvertes.fr/pasteur-02195957

Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner

Autor: Ioanna S. Sougleri, Konstantinos S. Papadakos, Andreas Mentis, Mairi P. Zadik, Dionyssios N. Sgouras, Mary Mavri-Vavagianni

Publikováno v: FEBS Journal
FEBS Journal, Wiley, 2016, 283 (2), pp.206-220. ⟨10.1111/febs.13592⟩

International audience; As a result of Helicobacter pylori adhesion to gastric epithelial cells, the bacterial effector cytotoxin-associated gene A (CagA) is translocated intra-cellularly, and after hierarchical tyrosine phosphorylation on multiple E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83a241e9789b56d39d44f02e73ee04c
https://pubmed.ncbi.nlm.nih.gov/26907789

Docosahexaenoic Acid Inhibits Helicobacter pylori Growth In Vitro and Mice Gastric Mucosa Colonization

Autor: José Carlos Machado, Rui M. Ferreira, Marta Correia, Valérie Michel, Maria José Oliveira, Patricia Almeida Carvalho, Eliette Touati, Raquel Seruca, Michel Huerre, Ceu Figueiredo, Marie-Agnès Dillies, A. Alves de Matos

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (4), pp.e35072. ⟨10.1371/journal.pone.0035072⟩
PLoS ONE, 2012, 7 (4), pp.e35072. ⟨10.1371/journal.pone.0035072⟩
PLoS ONE, Vol 7, Iss 4, p e35072 (2012)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

International audience; H. pylori drug-resistant strains and non-compliance to therapy are the major causes of H. pylori eradication failure. For some bacterial species it has been demonstrated that fatty acids have a growth inhibitory effect. Our ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abbac2a14a69e6c041df04f81c49508
https://hal.archives-ouvertes.fr/hal-01651966