A 4.5-Year Within-Patient Evolution of a Colistin-Resistant Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae Sequence Type 258

Autor: Eric Farfour, Rémy A. Bonnin, Isabelle Rosinski-Chupin, Philippe Glaser, Agnès B Jousset, Laurent Dortet, Delphine Girlich, Hélène Frech, Thierry Naas, Gaelle Cuzon, Nicolas Cabanel

Publikováno v: Clinical Infectious Diseases
Clinical Infectious Diseases, Oxford University Press (OUP), 2018, 67 (9), pp.1388-1394. ⟨10.1093/cid/ciy293⟩
Clinical Infectious Diseases, 2018, 67 (9), pp.1388-1394. ⟨10.1093/cid/ciy293⟩

International audience; Background. Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) has emerged globally over the last decade as a major nosocomial pathogen that threatens patient care. These highly resistant bacteria are m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60134fa1435e7d2c8e925dfa54da9578
https://doi.org/10.1093/cid/ciy293

Inhibitors of the Neisseria meningitidis PilF ATPase provoke type IV pilus disassembly

Autor: Cedric Couturier, Sylvie Goussard, Guillaume Duménil, Dorian Obino, Youxin Kong, Ximing Xu, Flore Aubey, Stéphane Renard, Catherine Lapeyrere, Judith Souphron, Jean-Philippe Corre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (17), pp.8481-8486. ⟨10.1073/pnas.1817757116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (17), pp.8481-8486. ⟨10.1073/pnas.1817757116⟩

International audience; Despite the availability of antibiotics and vaccines, Neisseria meningitidis remains a major cause of meningitis and sepsis in humans. Due to its extracellular lifestyle, bacterial adhesion to host cells constitutes an attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cd36dd5177d67e6129ff39dca8b82b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03100484/file/Aubey_et_al-Author_manuscript-HAL_Pasteur.pdf

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

Autor: Olivera Francetic, Scott J. Hultgren, Henry L. Schreiber, Caitlin N. Spaulding, Karen W. Dodson, Weili Zheng, Pontus Svenmarker, Fengbin Wang, Edward H. Egelman, Jennie E Hazen, Magnus Andersson, Matt S. Conover, Areli Luna-Rico

Publikováno v: eLife
eLife, eLife Sciences Publication, 2018, 7, pp.e31662. ⟨10.7554/eLife.31662⟩
eLife, Vol 7 (2018)
eLife, 2018, 7, pp.e31662. ⟨10.7554/eLife.31662⟩

Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8e13b6cd0e9b5e23ba08b4d46c2d1e
https://hal-pasteur.archives-ouvertes.fr/pasteur-02565620/document

Analysis of Bacterial Pilus Assembly by Shearing and Immunofluorescence Microscopy

Autor: Olivera Francetic, Areli Luna-Rico, Jenny-Lee Thomassin

Publikováno v: Methods in Molecular Biology
Springer. Methods in Molecular Biology, 1764, Humana Press, New York, NY, pp.291-305, 2018, Protein Complex Assembly, 978-1-4939-7758-1. ⟨10.1007/978-1-4939-7759-8_18⟩
Protein Complex Assembly ISBN: 9781493977581

International audience; Bacterial surface appendages of the type 4 pilus superfamily play diverse roles in adherence, aggregation, motility, signaling, and macromolecular transport. Here we describe two analytical approaches to study assembly of type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e977274899c4509ffbb45c570d5b5e
https://hal-pasteur.archives-ouvertes.fr/pasteur-02559622

Pseudopilin residue E5 is essential for recruitment by the type 2 secretion system assembly platform

Autor: Nivaskumar, Mangayarkarasi, Santos-Moreno, Javier, Malosse, Christian, Nadeau, Nathalie, Chamot-Rooke, Julia, Tran Van Nhieu, Guy, Francetic, Olivera

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2016, 101 (6), pp.924-941. ⟨10.1111/mmi.13432⟩
Molecular Microbiology, 2016, 101 (6), pp.924-941. ⟨10.1111/mmi.13432⟩

International audience; Type II secretion systems (T2SSs) promote secretion of folded proteins playing important roles in nutrient acquisition, adaptation and virulence of Gram-negative bacteria. Protein secretion is associated with the assembly of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::986395b8adb44f646d5f59b67fcfdff5
https://hal-pasteur.archives-ouvertes.fr/pasteur-02282206/document