Zobrazeno 1 - 10 of 67 pro vyhledávání: '"MESH: Extracellular Signal-Regulated MAP Kinases"'
1
Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation
Autor: Marie Octave, Laurence Pirotton, Audrey Ginion, Valentine Robaux, Sophie Lepropre, Jérôme Ambroise, Caroline Bouzin, Bruno Guigas, Martin Giera, Marc Foretz, Luc Bertrand, Christophe Beauloye, Sandrine Horman
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (23), pp.13129. ⟨10.3390/ijms222313129⟩
International Journal of Molecular Sciences, 22(23). MDPI
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13129
International Journal of Molecular Sciences, Vol 22, Iss 13129, p 13129 (2021)
International journal of molecular sciences, Vol. 22, no. 23, p. 13129 [1-17] (2021)
International audience; Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the ace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d460f33aa769cd4b3b498816c1247
https://doi.org/10.3390/ijms222313129
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2
A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling
Autor: Sylviane Hoos, Chi Zhang, Gitte W. Haxholm, Patrick England, Birthe B. Kragelund, Isabelle Broutin, Florence Boutillon, Mads Nygaard, Marie Bernadet, Vincent Goffin
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩
Journal of Biological Chemistry, 2015, 290 (19), pp.11890-11904. ⟨10.1074/jbc.M115.639096⟩
Cytokine receptors elicit several signaling pathways, but it is poorly understood how they select and discriminate between them. We have scrutinized the prolactin receptor as an archetype model of homodimeric cytokine receptors to address the role of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8d333304e6a7dd4f047e2215330516
https://doi.org/10.1074/jbc.m115.639096
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3
Cytosolic phospholipase A2α enhances mouse mortality induced by Pseudomonas aeruginosa pulmonary infection via interleukin 6
Autor: Laurent Guillemot, Lhousseine Touqui, Erwan Pernet, Dominique Leduc, Michel Chignard, Yongzheng Wu, Mathieu Medina
Publikováno v: Biochimie
Biochimie, Elsevier, 2014, 107, pp.95-104. ⟨10.1016/j.biochi.2014.08.018⟩
Biochimie, 2014, 107, pp.95-104. ⟨10.1016/j.biochi.2014.08.018⟩
International audience; Pseudomonas aeruginosa pulmonary infection is a leading cause of death in numerous diseases such as cystic fibrosis (CF). The host cytosolic phospholipase A2α (cPLA2α) releases lipid mediators that play an important role in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41341c6eb135708e8c8584da4192598a
https://doi.org/10.1016/j.biochi.2014.08.018
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4
ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription
Autor: Richard Treisman, Stuart Horswell, Aengus Stewart, Gavin Kelly, Phil East, Francesco Gualdrini, Nik Matthews, Cyril Esnault
Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2017, 65 (6), pp.1081-1095.e5. ⟨10.1016/j.molcel.2017.02.005⟩
Summary We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated ternary complex factor family of SRF partner proteins. In MEFs, activation of ERK by TPA stimulation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5fe23111a617313cae3aea01ae42c5
https://hal.archives-ouvertes.fr/hal-03022260
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5
Coexpression of major histocompatibility complex class II with chemokines and nuclear NFκB p50 in melanoma: a rational for their association with poor prognosis
Autor: Olivier Verola, Manuelle Viguier, Frédérique Deshayes, Jessica Lauriol, Dominique Charron, Isabelle Martins, Khaoussou Sylla, Catherine Alcaide-Loridan, Marie-Caroline Dieu-Nosjean, Reem Al-Daccak, Stephanie Ghislin
Publikováno v: Melanoma Research
Melanoma Research, Lippincott, Williams & Wilkins, 2009, 19 (4), pp.226-37. ⟨10.1097/CMR.0b013e32832e0bc3⟩
Melanoma Research, Lippincott, Williams & Wilkins, 2009, 19 (4), pp.226-37. 〈10.1097/CMR.0b013e32832e0bc3〉
Melanoma Research, 2009, 19 (4), pp.226-37. ⟨10.1097/CMR.0b013e32832e0bc3⟩
International audience; The constitutive expression of major histocompatibility complex class II (MHC II) molecules in melanoma is highly unusual and has been associated with unfavorable clinical outcome and higher metastatic dissemination. This asso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a96368071a96b16727d82f9f2ae9f
https://doi.org/10.1097/cmr.0b013e32832e0bc3
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6
Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain
Autor: Alexandre David, Cynthia Marie-Claire, Cindie Courtin, Florence Noble, Corinne Canestrelli, Julie Salzmann
Publikováno v: Brain Research
Brain Research, 2007, 1134 (1), pp.12-7. ⟨10.1016/j.brainres.2006.11.065⟩
Brain Research, Elsevier, 2007, 1134 (1), pp.12-7. 〈10.1016/j.brainres.2006.11.065〉
Brain Research, Elsevier, 2007, 1134 (1), pp.12-7. ⟨10.1016/j.brainres.2006.11.065⟩
International audience; Drugs of abuse induce alterations in cytoskeletal and cytoskeleton associated genes in several brain areas. We have previously shown that acute MDMA regulates the mRNA level of Rnd3, a Rho GTPase involved in actin cytoskeleton
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff6c1eee9c122016aed2b890dd429d
https://doi.org/10.1016/j.brainres.2006.11.065
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7
ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma
Autor: Primot, Aline, Mogha, Ariane, Corre, Sébastien, Roberts, Karen, Debbache, Julien, Adamski, Henri, Dreno, Brigitte, Khammari, Amir, Lesimple, Thierry, Méreau, Agnès, Goding, Colin, Galibert, Marie-Dominique
Publikováno v: Pigment Cell Melanoma Res
Pigment Cell Melanoma Res, 2010, 23 (1), pp.93-102. ⟨10.1111/j.1755-148X.2009.00652.x⟩
International audience; The master regulator of the melanocyte lineage Mitf is intimately involved in development as well as melanoma, controlling cell survival, differentiation, proliferation and metastasis/migration. Consistent with its central rol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::401d76b5b6e91d0dd2abc95176ff9dae
https://doi.org/10.1111/j.1755-148x.2009.00652.x
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8
Dominant role of GABAB2 and Gβγ for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons
Autor: Jianfeng Liu, Chanjuan Xu, Federica Bertaso, Philippe Rondard, Fangli Cao, Xueying Zhang, Haijun Tu, Jean-Philippe Pin
Publikováno v: Cellular Signalling
Cellular Signalling, Elsevier, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
Cellular Signalling, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a59756fac6ff9808e096f44b759e97
https://doi.org/10.1016/j.cellsig.2007.05.004
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9
Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression
Autor: Mireille Cormont, T Grémeaux, Jennifer Jager, Yannick Le Marchand-Brustel, Jean-François Tanti
Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2007, 148 (1), pp.241-51. ⟨10.1210/en.2006-0692⟩
Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced by adipose tissue in obesity could alter insulin signaling and action. Recent studies have shown a relationship between IL-1beta level and metabolic sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502a891031b530affe16248045bf5864
https://doi.org/10.1210/en.2006-0692
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10
Actomyosin bundles serve as a tension sensor and a platform for ERK activation
Autor: Sri Ram Krishna Vedula, Benoit Ladoux, Masahiro Sokabe, Chwee Teck Lim, Mukund Gupta, Hiroaki Hirata
Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2015, 16 (2), pp.250-7. ⟨10.15252/embr.201439140⟩
International audience; Tensile forces generated by stress fibers drive signal transduction events at focal adhesions. Here, we report that stress fibers per se act as a platform for tension-induced activation of biochemical signals. The MAP kinase,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e00be38a4b297346fe33828c83b72
https://hal.archives-ouvertes.fr/hal-01220909
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