Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

Autor: Jaeki Min, Haian Fu, Dima Kozakov, Yuhong Du, David R. Hall, Pierre J. Talbot, Regina Cencic, Raymond Dingledine, Sandor Vajda, Marc Desforges, Jerry Pelletier

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2011, 85 (13), pp.6381-9. ⟨10.1128/JVI.00078-11⟩

Coronaviruses are a family of enveloped single-stranded positive-sense RNA viruses causing respiratory, enteric, and neurologic diseases in mammals and fowl. Human coronaviruses are recognized to cause up to a third of common colds and are suspected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdde7ea09b8398c6a9b548e9afe6cb0
https://doi.org/10.1128/jvi.00078-11

Cyclin B synthesis and rapamycin-sensitive regulation of protein synthesis during starfish oocyte meiotic divisions

Autor: Jean-Claude Lozano, Laure Lapasset, Nathalie Oulhen, Gérard Peaucellier, Valérie Vergé, Bérengère Pradet-Balade, Patrick Cormier

Publikováno v: Molecular Reproduction and Development
Molecular Reproduction and Development, Wiley, 2008, 75 (11), pp.1617-26. 〈10.1002/mrd.20905〉
Molecular Reproduction and Development, Wiley, 2008, 75 (11), pp.1617-26. ⟨10.1002/mrd.20905⟩
Molecular Reproduction and Development, 2008, 75 (11), pp.1617-26. ⟨10.1002/mrd.20905⟩

Translation of cyclin mRNAs rep- resents an important event for proper meiotic matura- tion and post-fertilization mitoses in many species. Translational control of cyclin B mRNA has been described to be achieved through two separate but related mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee1ec6da0c2b0051ca6f39e6d509117
https://hal.archives-ouvertes.fr/hal-00358499

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

Autor: Jörg H. Fritz, Mauro Costa-Mattioli, Tommy Alain, Nathaniel Robichaud, Polen Sean, Yuri V. Svitkin, Amy B. Rosenfeld, Derek Walsh, Maritza Jaramillo, Martin Olivier, Liwei Rong, Rodney Colina, Ivan Topisirovic, Annie Sylvestre, Nahum Sonenberg, Barbara Herdy, Earl G. Brown, Ian Mohr, Ryan J.O. Dowling, Luc Furic, Mariko Kobayashi

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2012, 13 (6), pp.543-50. ⟨10.1038/ni.2291⟩

International audience; Type I interferon is an integral component of the antiviral response, and its production is tightly controlled at the levels of transcription and translation. The eukaryotic translation-initiation factor eIF4E is a rate-limiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7aa30c267f1910ff4d89ef71ea2afa
https://europepmc.org/articles/PMC4032494/

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

Autor: Edvin Klosi, Nathan J. Moerke, Gerhard Wagner, Elizabeth C. Arnold, Michael Chorev, Eric Klann, Richard E. Lloyd, Charles A. Hoeffer, Philippe Pierre, Ricard A. Rodriguez, Enrico K. Schmidt, Joseph E. LeDoux, Jessica L. Banko, Kiriana K. Cowansage

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩

International audience; Considerable evidence indicates that the general blockade of protein synthesis prevents both the initial consolidation and the postretrieval reconsolidation of long-term memories. These findings come largely from studies of dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f666ff10a23d221a8b618e2ef523d45b
https://hal.archives-ouvertes.fr/hal-00609468

A variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation system

Autor: Nathalie Oulhen, Julia Morales, Sandrine Boulben, Michael Bidinosti, Bertrand Cosson, Patrick Cormier

Publikováno v: PLoS ONE
PLoS ONE, 2009, 4 (3), pp.e5070. ⟨10.1371/journal.pone.0005070⟩
PLoS ONE, Vol 4, Iss 3, p e5070 (2009)
PLoS ONE, Public Library of Science, 2009, 4 (3), pp.e5070. ⟨10.1371/journal.pone.0005070⟩

International audience; BACKGROUND: 4E-BP is a translational inhibitor that binds to eIF4E to repress cap-dependent translation initiation. This critical protein:protein interaction is regulated by the phosphorylation of 4E-BP. Hypophosphorylated 4E-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27105a4dc192e97b391fc00a760b8d2f
https://hal.science/hal-00410966