The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Autor: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani

Publikováno v: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩

International audience; The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as cholesterol in animals. We found that it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cab00f461442b882b9cc5b78e1a41
https://doi.org/10.1016/j.molbiopara.2018.10.001

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

Autor: Olivier Le Tonquèze, Emélie Marquenet, Yann Audic, Hugues Roest Crollius, Jérôme Saulière, Zhen Wang, Hervé Le Hir, Isabelle Barbosa, Luc Paillard, Valentine Murigneux

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2012, 19 (11), pp.1124-31. ⟨10.1038/nsmb.2420⟩
Nature Structural and Molecular Biology, Nature Publishing Group, 2012, 19 (11), pp.1124-31. ⟨10.1038/nsmb.2420⟩

International audience; The exon junction complex (EJC) is a central effector of the fate of mRNAs, linking nuclear processing to mRNA transport, translation and surveillance. However, little is known about its transcriptome-wide targets. We used cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a36d2b34ab3bcc2f5dd6621ba07c334
https://doi.org/10.1038/nsmb.2420

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

Autor: Hervé Le Hir, Hala Chamieh, Jesper S. Johansen, Lionel Ballut, Bertrand Séraphin, Gregers R. Andersen, Christian Brix Folsted Andersen, Cristiano L. P. Oliveira, Jan Skov Pedersen, Klaus H. Nielsen

Publikováno v: Science
Science, American Association for the Advancement of Science, 2006, 313 (5795), pp.1968-72. ⟨10.1126/science.1131981⟩
Andersen, C B F, Ballut, L, Johansen, J S, Chamieh, H, Nielsen, K H, Oliveira, C, Pedersen, J S, Seraphin, B, LeHir, H & Andersen, G R 2006, ' Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA ', Science, vol. 313, pp. 1968-1972 .
Aarhus University

In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331fd4e19df2391b06c89ffb975248e0
https://hal.archives-ouvertes.fr/hal-00168014

The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase

Autor: Marc Fellous, Pedro M. Alzari, P. Leroy, David Sassoon, D. Wolgemuth

Publikováno v: Cell
Cell, 1989, 57 (4), pp.549-559. ⟨10.1016/0092-8674(89)90125-6⟩
Cell, Elsevier, 1989, 57 (4), pp.549-559. ⟨10.1016/0092-8674(89)90125-6⟩

International audience; The murine PL10 cDNA corresponds to a transcript expressed only in the male germ line. Its expression is developmentally regulated, with high levels of transcripts being present during the meiotic and haploid stages of spermat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7630ad600c6d9a03e62b2a7383c987b4
https://hal-pasteur.archives-ouvertes.fr/pasteur-03136446