Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis

Autor: Mindy Tsai, Nicolas Gaudenzio, Axel Roers, See-Ying Tam, Yuko Kawakami, Pierre Chambon, Philipp Starkl, Dimitri Pirottin, Stephen J. Galli, Sophie El Abbas, Jinah Kim, Nadine Antoine, Fabrice Bureau, Oliwia W Zurek, Laurent L. Reber, Toshiaki Kawakami, Thomas Marichal, Riccardo Sibilano

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2016, 126 (12), pp.4497-4515. ⟨10.1172/JCI86359⟩

International audience; Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542066fd135b8c7de9d713b77f413dc3
https://doi.org/10.1172/jci86359

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Autor: Carine Bonnard, Mohamed Denguezli, Ali Saad, François Malecaze, John E. Connolly, Seth L. Masters, Hazel Tye, Moez Gribaa, John A. McGrath, Kim S. Robinson, Ons Mamaï, Vincent Soler, Aristotle Lau, Reshmaa Balaji, Ildikó Szeverényi, Atsushi Otsuka, Masashi Akiyama, Pierre Fournié, Richard Hopkins, Keya Roy, Patricia J. Ahl, Sebastian Hiller, Lorenzo Sborgi, Lobna Boussofara, L. A. Jones, Roxana Ioana Nedelcu, Kenji Kabashima, Salma Samir Omar, Takuya Takeichi, E. Birgitte Lane, Franklin L. Zhong, Paul J. Baker, Bruno Reversade, Lukáš Lacina

Publikováno v: Cell
Cell, Elsevier, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
Cell, 167(1), 187-+. Cell Press
Cell, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩

International audience; Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we report that germline mutations in the inflammasome sensor NLRP1 cause tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4463444006fe6db979bfa8173593c7
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03158675

Counterregulation between thymic stromal lymphopoietin– and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects

Autor: Jiagui Li, Nathalie Jonca, Marie-Christine Birling, Aurelie Eisenmann, Mei Li, Sarra Zaafouri, Guy Serre, Pierre Hener, Juan Manuel Leyva-Castillo

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2016, 138 (1), pp.150-161.e13. ⟨10.1016/j.jaci.2016.01.013⟩
Journal of Allergy and Clinical Immunology, 2016, 138 (1), pp.150-161.e13. ⟨10.1016/j.jaci.2016.01.013⟩

International audience; Background: Epidermal barrier dysfunction has been recognized as a critical factor in the initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis (AD) and AD-like congenital disorders,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13df88fe07ec963acbad37d10cc910a
https://doi.org/10.1016/j.jaci.2016.01.013