Výsledky vyhledávání - "MESH: Enzyme Activation"

Structural basis of tankyrase activation by polymerization

Autor: Nisha Pillay, Laura Mariotti, Mariola Zaleska, Oviya Inian, Matthew Jessop, Sam Hibbs, Ambroise Desfosses, Paul C. R. Hopkins, Catherine M. Templeton, Fabienne Beuron, Edward P. Morris, Sebastian Guettler

Publikováno v: Nature
Nature, 2022, 612 (7938), pp.162-169. ⟨10.1038/s41586-022-05449-8⟩

The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-relevant cellular processes, including WNT–β-catenin signalling, telomere length maintenance, Hippo signalling, DNA damage repair and glucose homeostasis1,2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbf5494b760f8ef8193e02877b4ab33
https://hal.science/hal-03967132

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The carbohydrate-active enzyme database: functions and literature

Autor: Nicolas Terrapon, Elodie Drula, Vincent Lombard, Marie-Line Garron, Suzan Dogan, Bernard Henrissat

Publikováno v: Nucleic Acids Research
Drula, E, Garron, M L, Dogan, S, Lombard, V, Henrissat, B & Terrapon, N 2022, ' The carbohydrate-active enzyme database: functions and literature ', Nucleic Acids Research, vol. 50, no. D1, gkab1045, pp. D571-D577 . https://doi.org/10.1093/nar/gkab1045
Nucleic Acids Research, 2022, 50 (D1), pp.D571-D577. ⟨10.1093/nar/gkab1045⟩

Thirty years have elapsed since the emergence of the classification of carbohydrate-active enzymes in sequence-based families that became the CAZy database over 20 years ago, freely available for browsing and download at www.cazy.org. In the era of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95cd8d68c72bb70debe6bfc79445b25
https://doi.org/10.1093/nar/gkab1045

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Biochemical and structural studies of two tetrameric nucleoside 2′-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Autor: Javier Acosta, Jesús Fernández-Lucas, Miguel Arroyo, Pierre Alexandre Kaminski, Iván Acebrón, Andrzej Joachimiak, José M. Mancheño, Boguslaw Nocek, Isabel de la Mata, Yohana Alfaro, Ruiying Y. Wu

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
REDICUC-Repositorio CUC
Corporación Universidad de la Costa
instacron:Corporación Universidad de la Costa
E-Prints Complutense. Archivo Institucional de la UCM
'International Journal of Biological Macromolecules ', vol: 192, pages: 138-150 (2021)
International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2021, 192, pp.138-150. ⟨10.1016/j.ijbiomac.2021.09.164⟩

13 págs., 6 figs., 3 tabs.
Nucleoside 2′-deoxyribosyltransferases (NDTs) catalyze the cleavage of glycosidic bonds of 2′-deoxynucleosides and the following transfer of the 2′-deoxyribose moiety to acceptor nucleobases. Here, we report the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52d9c7633a2cfed4df23ffe3deeb5e2
http://hdl.handle.net/10261/255525

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Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Autor: Chandini Bhaskar Naidu, Joanna Timmins, Fabienne Hans, Muge Senarisoy

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9226, p 9226 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (23), pp.9226. ⟨10.3390/ijms21239226⟩
International Journal of Molecular Sciences, 2020, 21 (23), pp.9226. ⟨10.3390/ijms21239226⟩

International audience; Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe damage to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ab3aa7711b687ca486c60dd62a3c6
https://www.mdpi.com/1422-0067/21/23/9226

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Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA

Autor: Pierre Khalfi, Valérie Thiers, Jean-Pierre Vartanian, Noémie Berry, Wenjuan Jiao, Vincent Caval, Rodolphe Suspène, Emmanuelle Pitré, Simon Wain-Hobson

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2019, 20 (1), pp.858. ⟨10.1186/s12864-019-6216-x⟩
BMC Genomics, 2019, 20 (1), pp.858. ⟨10.1186/s12864-019-6216-x⟩
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)

BackgroundAPOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases APOBEC3A (A3A), APOBEC3B (A3B)

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02545764

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Very Early Blood Diffusion of the Active Lethal and Edema Factors of Bacillus anthracis After Intranasal Infection

Autor: Pierre L. Goossens, François Becher, Clémence Rougeaux, Jean-Nicolas Tournier

Publikováno v: The Journal of Infectious Diseases
Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2020, 221 (4), pp.660-667. ⟨10.1093/infdis/jiz497⟩
Journal of Infectious Diseases, 2020, 221 (4), pp.660-667. ⟨10.1093/infdis/jiz497⟩

Background Lethal and edema toxins are critical virulence factors of Bacillus anthracis. Few data are available on their presence in the early stage of intranasal infection. Methods To investigate the diffusion of edema factor (EF) and lethal factor

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https://pubmed.ncbi.nlm.nih.gov/31574153

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A Founder Effect of c.257 + 2T > C Mutation in NCF2 Gene Underlies Severe Chronic Granulomatous Disease in Eleven Patients

Autor: Khaoula Ben-Farhat, Monia Khemiri, Zohra Fitouri, Sihem Barsaoui, Najla Mekki, Meriem Ben-Ali, Selim Abdelmoula, Mohamed-Neji Guediche, M. R. Barbouche, Samir Boukthir, Saber Hamami, Imen Ben-Mustapha, Amel Ben-Chehida, Jalel Chemli, Karen Rouault, Beya Larguèche

Publikováno v: Journal of Clinical Immunology
Journal of Clinical Immunology, Springer Verlag, 2016, 36 (6), pp.547-554. ⟨10.1007/s10875-016-0299-9⟩

International audience; Chronic granulomatous disease (CGD) is the prototypic functional neutrophil disorder caused by genetic defects in one of the five genes encoding the superoxide-generating nicotinamide adenine dinucleotide phosphate (NADPH)-oxi

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https://doi.org/10.1007/s10875-016-0299-9

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Rescue of GSDIII Phenotype with Gene Transfer Requires Liver- and Muscle-Targeted GDE Expression

Publikováno v: Molecular Therapy
Molecular Therapy, 2018, 26 (3), pp.890-901. ⟨10.1016/j.ymthe.2017.12.019⟩
Molecular Therapy, Nature Publishing Group, 2018, 26 (3), pp.890-901. ⟨10.1016/j.ymthe.2017.12.019⟩
Molecular Therapy, Cell Press, 2018, 26 (3), pp.890-901. ⟨10.1016/j.ymthe.2017.12.019⟩

International audience; Glycogen storage disease type III (GSDIII) is an autosomal recessive disorder caused by a deficiency of glycogen-debranching enzyme (GDE), which results in profound liver metabolism impairment and muscle weakness. To date, no

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https://hal.science/hal-02332988

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LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration

Autor: Maillet, Vanessa, Boussetta, Nadia, Leclerc, Jocelyne, Fauveau, Veronique, Foretz, Marc, Viollet, Benoit, Couty, Jean-Pierre, Celton-Morizur, Séverine, Perret, Christine, Desdouets, Chantal

Publikováno v: Cell Reports
Cell Reports, 2018, 22 (8), pp.1994-2005. ⟨10.1016/j.celrep.2018.01.086⟩
Cell Reports, Vol 22, Iss 8, Pp 1994-2005 (2018)
Cell Reports, Elsevier Inc, 2018, 22 (8), pp.1994-2005. ⟨10.1016/j.celrep.2018.01.086⟩

Comment inLKB1: Controlling Quiescence and Genomic Integrity at Home. [Trends Endocrinol Metab. 2018]; International audience; Liver kinase B1 (LKB1) is involved in several biological processes and is a key regulator of hepatic metabolism and polarit

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https://www.hal.inserm.fr/inserm-02349915/document

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Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos

Autor: Anna Noatynska, Nicolas Tavernier, Lionel Pintard, Monica Gotta, Lisa Martino, Françoise Schwager, Thibaut Léger, Costanza Panbianco, Lucie Van Hove

Publikováno v: The Journal of cell biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2015, 208 (6), pp.661-9. ⟨10.1083/jcb.201408064⟩
The Journal of Cell Biology
The Journal of Cell Biology, Vol. 208, No 6 (2015) pp. 661-9

Phosphorylation of SPAT-1/Bora by Cdk1 enhances Plk1 phosphorylation by Aurora A and promotes entry into mitosis in C. elegans.
The molecular mechanisms governing mitotic entry during animal development are incompletely understood. Here, we show

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