Výsledky vyhledávání - "MESH: Enterovirus B, Human"

Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases

Autor: Stéphanie Beaucourt, Colleen L. Watkins, Brian J. Kempf, David J. Barton, Olve B. Peersen

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (31), pp.10624-10637. ⟨10.1074/jbc.RA120.013906⟩
Journal of Biological Chemistry, 2020, 295 (31), pp.10624-10637. ⟨10.1074/jbc.RA120.013906⟩
J Biol Chem

International audience; Picornaviral RNA-dependent RNA polymerases (RdRPs) have low replication fidelity that is essential for viral fitness and evolution. Their global fold consists of the classical "cupped right hand" structure with palm, fingers,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3fad718547c0ef67fb1fe4dcfc91b0
https://hal-pasteur.archives-ouvertes.fr/pasteur-03216660

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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Autor: Mathy Froeyen, Leen Delang, Stéphanie Beaucourt, Bruno Canard, Ana Theresa Silveira de Morais, Isabelle Imbert, Johan Neyts, Marco Vignuzzi, Hervé Blanc, Pieter Leyssen, Rana Abdelnabi

Publikováno v: Journal of Virology
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩

Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ec8ca79e6936169943b98e6fae68ff
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928

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Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo

Autor: Marco Vignuzzi, Olve B. Peersen, Seth McDonald, Gonzalo Moratorio, Stéphanie Beaucourt, Andrew Block

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
COLIBRI
Universidad de la República
instacron:Universidad de la República
Journal of Biological Chemistry, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩

International audience; Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc79364b4ebc9b544b7b581079965a03
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545937

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Molecular epidemiology of coxsackievirus type B1

Autor: Dorra Rezig, Mohamed Seghier, Henda Touzi, Zina Meddeb, Ahlem Ben Yahia, Henda Triki, Ichrak Abdelkhalek

Publikováno v: Archives of Virology
Archives of Virology, Springer Verlag, 2015, 160 (11), pp.2815-2821. ⟨10.1007/s00705-015-2561-5⟩

International audience; Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65b6f43021d746892925521066a0387
https://hal-riip.archives-ouvertes.fr/pasteur-01375030

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Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases

Autor: Seth McDonald, Stéphanie Beaucourt, Grace Campagnola, Olve B. Peersen, Marco Vignuzzi

Publikováno v: Journal of Virology
Journal of Virology, 2015, 89 (1), pp.275-286. ⟨10.1128/JVI.01574-14⟩
Journal of Virology, American Society for Microbiology, 2015, 89 (1), pp.275-286. ⟨10.1128/JVI.01574-14⟩

Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b348407b013c131c7d5bc4edd90e8
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545941

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Molecular comparison of echovirus 11 strains circulating in Europe during an epidemic of multisystem hemorrhagic disease of infants indicates that evolution generally occurs by recombination

Autor: Francis Delpeyroux, Sophie Guillot, Jean Balanant, György Berencsi, Stéphane Chevaliez, Andrea Szendrôi, Valérie Caro

Publikováno v: Virology
Virology, Elsevier, 2004, 325 (1), pp.56-70. ⟨10.1016/j.virol.2004.04.026⟩
Virology, 2004, 325 (1), pp.56-70. ⟨10.1016/j.virol.2004.04.026⟩

International audience; We compared echovirus 11 (E11) strains implicated in a severe epidemic in Hungary in 1989 with the prototype E11 strain Gregory and with other E11 strains, most of which were isolated over the same period in Europe (Finland, T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873b747515849da8de598c99bb6f7205
https://doi.org/10.1016/j.virol.2004.04.026

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Coxsackievirus B3 mutator strains are attenuated in vivo

Autor: Hervé Blanc, Stéphanie Beaucourt, Nina F. Gnädig, Grace Campagnola, Antonio V. Bordería, Marta Sanz-Ramos, Peng Gong, Olve B. Peersen, Marco Vignuzzi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (34), pp.E2294-303. ⟨10.1073/pnas.1204022109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (34), pp.E2294-303. ⟨10.1073/pnas.1204022109⟩
Proceedings of the National Academy of Sciences

International audience; Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb7ef443aaf1be4e0ca56a44ca13595
https://hal-pasteur.archives-ouvertes.fr/pasteur-00918212

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Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis

Autor: Craig E. Cameron, Christian Castro, Jessica E. Galarraga, Marco Vignuzzi, Nina F. Gnädig, Jason D. Graci

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2012, 86 (5), pp.2869-73. ⟨10.1128/JVI.05712-11⟩
Journal of Virology, 2012, 86 (5), pp.2869-73. ⟨10.1128/JVI.05712-11⟩

The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4cb983d8f0804e103cd0870782aa48

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Phylogenetic analysis of complete VP1 sequences of echoviruses 11 and 6: high genetic diversity and circulation of genotypes with a wide geographical and temporal range

Autor: Dorra Rezig, Wasfi Fares, Henda Triki, Mohamed Seghier, Henda Touzi, Ahlem Ben Yahia

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, Society for General Microbiology, 2011, 60 (Pt 7), pp.1017-25. ⟨10.1099/jmm.0.028795-0⟩

International audience; Echovirus 6 (E6) and echovirus 11 (E11) are common causes of meningitis and other human diseases; they are among the most frequently isolated enteroviruses worldwide. In the present work we have studied genetic variability ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec69e03d7444ced5ecea3480dd340dc
https://pubmed.ncbi.nlm.nih.gov/21436366

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