Zobrazeno 1 - 10 of 38 pro vyhledávání: '"MESH: Enhancer Elements, Genetic"'
1
H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation
Autor: Tiphaine M. N. Camarasa, Catherine Fitting, Melanie Hamon, Jean-Marc Cavaillon, Orhan Rasid, Christine Chevalier
Publikováno v: Cell Reports, Vol 29, Iss 12, Pp 3933-3945.e3 (2019)
Cell Reports
Cell Reports, Elsevier Inc, 2019, 29 (12), pp.3933-3945.e3. ⟨10.1016/j.celrep.2019.11.043⟩
Cell Reports, 2019, 29 (12), pp.3933-3945.e3. ⟨10.1016/j.celrep.2019.11.043⟩
Summary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a20890c1a5945353b333d276cd07fc
http://www.sciencedirect.com/science/article/pii/S2211124719315256
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2
Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
Autor: Katja Langenfeld, Francina Langa, S. Bastide, François Spitz, Andreas Hörnblad
Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.439. ⟨10.1038/s41467-020-20714-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.439. ⟨10.1038/s41467-020-20714-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Developmental genes are often regulated by multiple elements with overlapping activity. Yet, in most cases, the relative function of those elements and their contribution to endogenous gene expression remain poorly characterized. An example of this p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be04ce5d4825aa6c9f9fb2a54ad000b
https://hal.sorbonne-universite.fr/hal-03128817/file/s41467-020-20714-y.pdf
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3
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Autor: Pierre Savatier, Nuria Montserrat, Laia Richart-Ginés, Camille Stephan-Otto Attolini, Raquel Bernad, Susana Prieto, Marta I. Sierra, Joaquín Pastor, Magdalena Zernicka-Goetz, Sonia Sánchez Martínez, Daniel Fisher, Javier Munoz, Sandrina Nóbrega-Pereira, Noelia Alcazar, Ana Martinez-Val, Gonzalo Gómez-López, Mario F. Fraga, Marta N. Shahbazi, Elisabeth Simboeck, Carmen Blanco-Aparicio, Elena Garreta, Osvaldo Graña-Castro, Alain Camasses, Irène Aksoy, Sagrario Ortega, Cian J. Lynch, Maribel Muñoz-Martin, Isabel A. Calvo, Agustín F. Fernández, Manuel Serrano, Carolina Tarantino
Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particularly FGF–MEK signallin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6662dbd5d60ba17897bdaeae5b24d
https://hal.archives-ouvertes.fr/hal-03234133
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4
Mutant NR5A1/SF-1 in patients with disorders of sex development shows defective activation of theSOX9TESCO enhancer
Autor: Anthony Daniel Bird, Andrew H. Sinclair, Vincent R. Harley, Brittany Croft, Faustine Declosmenil, Peter Koopman, Louisa Mabel Ludbrook, Francis Poulat, Ken McElreavey, Kevin Christopher Knower, Brett Daniel Fisher, Janelle Ryan, Anu Bashamboo, Rajini Sreenivasan
Publikováno v: Human Mutation
Human Mutation, 2018, 39 (12), pp.1861-1874. ⟨10.1002/humu.23603⟩
International audience; Nuclear receptor subfamily 5 group A member 1/Steroidogenic factor 1 (NR5A1; SF-1; Ad4BP) mutations cause 46,XY disorders of sex development (DSD), with phenotypes ranging from developmentally mild (e.g., hypospadias) to sever
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bf3bb6c1222048f9bebd0d6dd26b0b
https://doi.org/10.1002/humu.23603
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5
A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer
Autor: Didier Busso, Lluis Quintana-Murci, Paul-Henri Romeo, Juliette Hamroune, Anaïs Assouvie, Germain Rousselet, Maxime Rotival
Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (11), pp.e1009090. ⟨10.1371/journal.pgen.1009090⟩
PLoS Genetics, Vol 16, Iss 11, p e1009090 (2020)
PLoS Genetics, 2020, 16 (11), pp.e1009090. ⟨10.1371/journal.pgen.1009090⟩
Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. Its effects strongly depend on its level and timing of expression. Therefore, the transcription of its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a80ae8119a6c1f941629a571c21e1be
https://pubmed.ncbi.nlm.nih.gov/33147208
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6
Implication of non-coding PAX6 mutations in aniridia
Autor: C. Jeanton-Scaramouche, Carmen Ayuso, Marta Corton, Lucas Fares-Taie, Patricia Ramos, I. Arroyo, Alice Goldenberg, D. Aguilera, Nicolas Chassaing, Jean-Michel Rozet, V. Gaston, Patrick Calvas, Julie Plaisancié, Fiona Blanco-Kelly, H. Dollfus, Christine Francannet, Cristina Villaverde, Maria Tarilonte, J. C. Kaplan
Publikováno v: Human Genetics
Human Genetics, Springer Verlag, 2018, 137 (10), pp.831-846. ⟨10.1007/s00439-018-1940-x⟩
International audience; There is an increasing implication of non-coding regions in pathological processes of genetic origin. This is partly due to the emergence of sophisticated techniques that have transformed research into gene expression by allow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a47ea9a42d72e3fff4855cdd9188f7
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03174772
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7
Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors
Autor: Umeshree Govender, Frédérique Michel, Yasmine Bourdache, Sandra Pellegrini, Béatrice Corre
Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩
Journal of Leukocyte Biology, 2017, 101 (5), pp.1181-1190. ⟨10.1189/jlb.2A0416-187RR⟩
Type I IFN can exert pro- and anti-inflammatory activities in the immune system. Here, we have investigated the mechanism by which IFN-α enhances early expression of the anti-inflammatory cytokine IL-10 in human CD45RA+CD4+ T cells. With the use of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2464e50cc98856b4358c2ff846e243
https://hal-pasteur.archives-ouvertes.fr/pasteur-02136992
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8
Peroxisome Proliferator-activated Receptor γ Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes
Autor: Stéphane Avner, Philippe Froguel, Bart Staels, Gilles Salbert, Philippe Lefebvre, Frédérik Oger, Jérôme Eeckhoute, Julie Dubois-Chevalier, Emmanuelle Durand, Céline Gheeraert
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2014, 289 (2), pp.708-22. ⟨10.1074/jbc.M113.526996⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (2), pp.708-22. ⟨10.1074/jbc.M113.526996⟩
International audience; The nuclear receptor peroxisome proliferator-activated receptor (PPAR) is a transcription factor whose expression is induced during adipogenesis and that is required for the acquisition and control of mature adipocyte function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7349ef1c6a85a4c44d1d8089118bb
https://doi.org/10.1074/jbc.m113.526996
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9
Super-Enhancers in the Control of Cell Identity and Disease
Autor: Tong Ihn Lee, Brian J. Abraham, Violaine Saint-André, Denes Hnisz, Alla A. Sigova, Ashley Lau, Heather A. Hoke, Richard A. Young
Publikováno v: Cell
Cell, Elsevier, 2013, 155 (4), pp.934-947. ⟨10.1016/j.cell.2013.09.053⟩
PMC
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of facto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19abd0410acfff560b1f82a45989af7
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10
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
Autor: Aymeric Silvin, Pierre-Emmanuel Joubert, Jacob-Sebastian Seeler, Ido Amit, Joao G. Magalhaes, Nicolas Manel, Jack-Christophe Cossec, Anne Dejean, Adrien Decque, Olivier Joffre, Ronnie Blecher-Gonen, Sebastian Amigorena, Pierre Lapaquette, Matthew L. Albert
Publikováno v: Nature Immunology
Nature Immunology, 2016, 17 (2), pp.140-149. ⟨10.1038/ni.3342⟩
Nature Immunology, Nature Publishing Group, 2016, 17 (2), pp.140-149. ⟨10.1038/ni.3342⟩
International audience; Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like receptors (TLRs) in myeloid cells, deficient sumoylation caused increas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082a2423966ca06422f4633b1d591ca6
https://hal-pasteur.archives-ouvertes.fr/pasteur-01380657
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