Výsledky vyhledávání - "MESH: Endoplasmic Reticulum"

Mitochondrial membrane biogenesis: A new pathway for lipid transport mediated by PERK/E-Syt1 complex

Autor: Morgane Michaud, Sébastien Leterme

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2023, 222 (3), pp.e202301132. ⟨10.1083/jcb.202301132⟩

Despite decades of extensive research, mitochondrial lipid transport is a process far from fully understood. In this issue, Sassano et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206008) identified a new complex, composed of E-Syt1 and PER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06d9c35c7c989a47f791ef9c96391e8
https://doi.org/10.1083/jcb.202301132

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Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

Autor: Ginés Luengo-Gil, Shivani Reddy, David S. Askew, Laura A. Woollett, Vishukumar Aimanianda, Sarah Sze Wah Wong, José P. Guirao-Abad, Nikita Malev, Christina Grisham, Martin Weichert

Publikováno v: mBio, Vol 12, Iss 5 (2021)
mBio
mBio, 2021, 12 (5), pp.e0273521. ⟨10.1128/mBio.02735-21⟩

International audience; Aspergillus fumigatus is a human-pathogenic mold that extracts nutrients from the environment or from host tissues by secreting hydrolytic enzymes. The ability of A. fumigatus to adjust secretion levels in proportion to demand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3ed62f3472da3d765c7c07f883d03e
https://journals.asm.org/doi/10.1128/mBio.02735-21

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Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩
Haematologica, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩

International audience; The liver hormone hepcidin controls the main inflows of iron into plasma by binding to and inducing the degradation or the occlusion of the iron export activity of ferroportin, the only known cellular exporter of iron. When he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f448f7c0fa5f39da70266cfaf09528b
https://hal.inrae.fr/hal-02911817/document

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Fat inclusions strongly alter membrane mechanics

Autor: Lionel Foret, Abdou Rachid Thiam, Alexandre Santinho, Aymeric Chorlay

Publikováno v: Biophysical Journal
Biophysical Journal, Biophysical Society, 2021, 120 (4), pp.607-617. ⟨10.1016/j.bpj.2021.01.009⟩
Biophys J

International audience; Neutral lipids (NLs) are apolar oil molecules synthesized in the endoplasmic reticulum bilayer upon diverse biological stimuli. NLs synthesized are released in the hydrophobic core of the bilayer. At a critical concentration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446f819bac0b8cd5e2fee6d1ed31cc1d
https://hal.sorbonne-universite.fr/hal-03267078

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Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy

Autor: Emmanuel L. Gautier, Amélie Lacombe, Dominique Farabos, Christine Rouault, Camille Gamblin, Antonin Lamaziere, Laurent Yvan-Charvet, Francina Langa-Vives, Karine Clément, Isabelle Dugail

Publikováno v: Diabetes
Diabetes, 2020, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩
Diabetes, 2021, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩
Diabetes, American Diabetes Association, 2020, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩

International audience; Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes, is unclear. We show that the isolated adipocyte fraction, but not the total un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06c80cfc4320a0df5576e5f9b288d1
https://hal.sorbonne-universite.fr/hal-03157930/document

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Zika virus subversion of chaperone GRP78/BiP expression in A549 cells during UPR activation

Autor: Chaker El Kalamouni, Wissal Harrabi, Jonathan Turpin, Pascale Krejbich-Trotot, Wildriss Viranaicken, Philippe Desprès, Juliano G. Haddad, Etienne Frumence

Publikováno v: Biochimie
Biochimie, 2020, 175, pp.99-105. ⟨10.1016/j.biochi.2020.05.011⟩
Biochimie, Elsevier, 2020, 175, pp.99-105. ⟨10.1016/j.biochi.2020.05.011⟩

International audience; Flaviviruses replicate in membranous factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus polyprotein integration contribute to ER stress and the host cell may exhibit an Unfolded Protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379f7906b792565c0ce0da00bfecc176
https://hal.univ-reunion.fr/hal-03119668/document

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Improvement of immunodetection of the transcription factor C/EBP homologous protein by western blot

Autor: Wildriss Viranaicken, Olivier Meilhac, Daed El Safadi, Jonathan Turpin, Pascale Krejbich-Trotot, Etienne Frumence

Publikováno v: Analytical Biochemistry
Analytical Biochemistry, Elsevier Masson, 2020, 601, pp.113775. ⟨10.1016/j.ab.2020.113775⟩
Analytical Biochemistry, 2020, 601, pp.113775. ⟨10.1016/j.ab.2020.113775⟩

International audience; Accumulation of misfolded proteins within the endoplasmic reticulum (ER) induces an unfolded protein response (UPR) that either restores homeostasis or triggers apoptosis in case of adaptation failure. The three activated bran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398db06f5d5f3e8155f6645e59aca4c4
https://pubmed.ncbi.nlm.nih.gov/32416096

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Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer

Autor: Isabelle Gross, Georg Mellitzer, Benoit Romain, Marjorie Sidhoum, Michel Pfeffer, Xiangjun Meng, Christian Gaiddon, Alain C. Jung, Jean-Batiste Delhorme, Aina Venkatasamy

Publikováno v: Molecules
Molecules, 2021, 26 (17), pp.5386. ⟨10.3390/molecules26175386⟩
Molecules, Vol 26, Iss 5386, p 5386 (2021)
Molecules, MDPI, 2021, 26 (17), pp.5386. ⟨10.3390/molecules26175386⟩

International audience; Metal complexes have been used to treat cancer since the discovery of cisplatin and its interaction with DNA in the 1960’s. Facing the resistance mechanisms against platinum salts and their side effects, safer therapeutic ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0169391807b88443af0bd53c03ab71a5
https://doi.org/10.3390/molecules26175386

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Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

Autor: Caroline, Demangel, Stephen, High

Publikováno v: Biology of the Cell
Biology of the Cell, 2018, 110 (11), pp.237-248. ⟨10.1111/boc.201800030⟩

International audience; Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin mycolactone. Recent studies have identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::56ac8b06b7916ac95b0ce4c34e171b69
https://doi.org/10.1111/boc.201800030

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Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation

Autor: Rosanne M. Crooke, Jianguo Wang, Xiaowei Sun, Jean-Paul Pais de Barros, Abhiruchi J Mehta, David Masson, Ji Miao, Mary E. Haas, Sudha B. Biddinger, Mark J. Graham, Masanori Aikawa

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (3), pp.1115-1122. ⟨10.1074/jbc.M115.668269⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (3), pp.1115-1122. 〈10.1074/jbc.M115.668269〉

IF 4.258; International audience; Diabetes is characterized by increased lipogenesis as well as increased endoplasmic reticulum (ER) stress and inflammation. The nuclear hormone receptor liver X receptor (LXR) is induced by insulin and is a key regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81f624d8956b525f5beba26ecaab86b
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01391796

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