Nanocarriers for drug delivery to the inner ear: Physicochemical key parameters, biodistribution, safety and efficacy

Autor: Amélie Bochot, Yann Nguyen, Céline Jaudoin, Evelyne Ferrary, Florence Agnely

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, 592, pp.120038-. ⟨10.1016/j.ijpharm.2020.120038⟩
International Journal of Pharmaceutics, 2021, 592, pp.120038. ⟨10.1016/j.ijpharm.2020.120038⟩

International audience; Despite the high incidence of inner ear disorders, there are still no dedicated medications on the market. Drugs are currently administered by the intratympanic route, the safest way to maximize drug concentration in the inner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b13eda59445b7c6ad5dd6a425cbb75e
https://pubmed.ncbi.nlm.nih.gov/33159985

Scoliose idiopathique de l’enfant : une maladie d’origine vestibulaire ?

Autor: Rubin, François

Publikováno v: Médecine humaine et pathologie. 2015

Introduction: idiopathie scoliosis in children is a frequent disease (3-4% of world population), with potentially heavy somatopsychic repercussions for the child (surgery, chronic respiratory failure, pain, depression…) and major Public Health cost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f899e57ee9656592e88d8e75f7e579db
https://dumas.ccsd.cnrs.fr/dumas-01231175/document

How minute sooglossid frogs hear without a middle ear

Autor: Thierry Aubin, Peter Cloetens, Philippe Herzog, Renaud Boistel, Nicolas Pollet, Thierry Scotti, Justin Gerlach, Françoise Peyrin, Jean-François Aubry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (38), pp.15360-4. ⟨10.1073/pnas.1302218110⟩
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (38), pp.15360-4. ⟨10.1073/pnas.1302218110⟩

International audience; Acoustic communication is widespread in animals. According to the sensory drive hypothesis [Endler JA (1993) Philos Trans R Soc Lond B Biol Sci 340(1292):215-225], communication signals and perceptual systems have coevolved. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e1219c8ec2d3cacebcb94244ed6df9
https://pubmed.ncbi.nlm.nih.gov/24003145

Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line

Autor: Daniel Butlen, Marie Teixeira, Say Viengchareun, Jérôme Nevoux, Evelyne Ferrary, Marc Lombès, Claudine Cosson

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2011, 585 (17), pp.2703-8. ⟨10.1016/j.febslet.2011.07.025⟩

International audience; A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c132d9ce6fa06983e758e28f48cb798
https://www.hal.inserm.fr/inserm-00656238/document

Receptors for leptin in the otic labyrinth and the cochlear-vestibular nerve of guinea pig are modified in hormone-induced anorexia

Autor: Kathleen C. Horner, Marie-Pierre Blanchard, Juliette Pio, Jean-Denis Troadec, Michel Dallaporta

Publikováno v: Hearing Research
Hearing Research, Elsevier, 2010, 270 (1-2), pp.48-55. ⟨10.1016/j.heares.2010.09.009⟩
Hearing Research, 2010, 270 (1-2), pp.48-55. ⟨10.1016/j.heares.2010.09.009⟩

International audience; Metabolic syndromic inner ear pathology is a recognized condition in clinical practice but the possible causes remain controversial. We have previously reported that chronically-implanted estrogen implants in guinea pig result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71dbe3cd4ed423965514280cc52cda1
https://pubmed.ncbi.nlm.nih.gov/20875846