Výsledky vyhledávání - "MESH: E2F1 Transcription Factor"

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

Autor: Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩

International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y

Zobrazit plný text záznamu

The CDK4-pRB-E2F1 pathway controls insulin secretion

Autor: Stéphane Dalle, Lluis Fajas, Safia Costes, Emilie Blanchet, Said Assou, Jean-Sébastien Annicotte, Irena Iankova, Claude Sardet, Carine Chavey, Jacques Teyssier

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-1023. ⟨10.1038/ncb1915⟩
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-23. 〈10.1038/ncb1915〉
Nature Cell Biology, 2009, 11 (8), pp.1017-23. ⟨10.1038/ncb1915⟩
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-23. ⟨10.1038/ncb1915⟩

International audience; CDK4-pRB-E2F1 cell-cycle regulators are robustly expressed in non-proliferating beta cells, suggesting that besides the control of beta-cell number the CDK4-pRB-E2F1 pathway has a role in beta-cell function. We show here that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff8a1404638ea3f738e39e2364f733d
https://pubmed.ncbi.nlm.nih.gov/19597485

Zobrazit plný text záznamu

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short)

Autor: Elisabeth Brambilla, Laurence Chaperot, Christian Brambilla, Olivier Micheau, Joel Plumas, Sylvie Gazzeri, Caroline Salon, Beatrice Eymin

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2006, 13 (2), pp.260-72. ⟨10.1038/sj.cdd.4401739⟩
Cell Death and Differentiation, Nature Publishing Group, 2006, 13 (2), pp.260-72. 〈10.1038/sj.cdd.4401739〉

E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously postulated that the low level of E2F1 in primary lung adenocarcinoma contributes to their carcinogenesis. Here, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362c92e058cf307028ee5328e7da8de4
https://pubmed.ncbi.nlm.nih.gov/16052233

Zobrazit plný text záznamu

E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

Autor: S. De Seranno, Beatrice Eymin, Elizabeth Brambilla, Valérie Edmond, Sylvie Gazzeri, G. Merdzhanova, Laurent Corcos, Christian Brambilla, A. Van Den Broeck

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2008, 15 (12), pp.1815-1823
Cell Death and Differentiation, Nature Publishing Group, 2008, 15 (12), pp.1815-23. ⟨10.1038/cdd.2008.135⟩
Cell Death and Differentiation, Nature Publishing Group, 2008, 15 (12), pp.1815-1823. ⟨10.1038/cdd.2008.135⟩
Cell Death and Differentiation, 2008, 15 (12), pp.1815-23. ⟨10.1038/cdd.2008.135⟩

Comment in Many pathways to apoptosis: E2F1 regulates splicing of apoptotic genes. [Cell Death Differ. 2008]; International audience; The transcription factor E2F1 has a key function during S phase progression and apoptosis. It has been well-demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48cb328657aab09b3766e7e1d46e311
https://www.hal.inserm.fr/inserm-02337615/file/Merdzhanova.pdf

Zobrazit plný text záznamu

E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors

Autor: Beatrice Eymin, G. Merdzhanova, Elisabeth Brambilla, Caroline Salon, Christian Brambilla, Sylvie Gazzeri

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2007, 26 (48), pp.6927-36. ⟨10.1038/sj.onc.1210499⟩
Oncogene, Nature Publishing Group, 2007, 26 (48), pp.6927-6936. ⟨10.1038/sj.onc.1210499⟩

International audience; The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated the relationships l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a02760113a7db2572a5ec125449683
https://www.hal.inserm.fr/inserm-00173067

Zobrazit plný text záznamu

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation

Autor: Olivier Ayrault, Beatrice Eymin, Laetitia Andrique, Sylvie Gazzeri, D Fauvin, Paule Séité

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (58), pp.7577-86. ⟨10.1038/sj.onc.1209743⟩

International audience; The nucleolar Arf protein has been shown to regulate cell cycle through both p53-dependent and -independent pathways. In addition to the well-characterized Arf-mdm2-p53 pathway, several partners of Arf have recently been descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d0104c3928541c99f6f913ecd368c
https://www.hal.inserm.fr/inserm-00175783

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání