Zobrazeno 1 - 10
of 83
pro vyhledávání: '"MESH: Drug Evaluation, Preclinical"'
Autor:
Paul Ogadinma, Yann Ayotte, Laurent Chatel-Chaix, François Bilodeau, Marthe Lebughe, Mena Cimino, Giulia Manina, Aïssatou Aïcha Sow, Frédéric J. Veyrier, Albert Descoteaux, Eve Bernet, Dominic Gagnon, Sarah-Lisa Ouali, Maxime Mistretta, Dave Richard, Steven R. LaPlante
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2021, 16 (11), pp.2158-2163. ⟨10.1021/acschembio.1c00657⟩
ACS Chemical Biology, 2021, 16 (11), pp.2158-2163. ⟨10.1021/acschembio.1c00657⟩
International audience; Fragment-based lead discovery has emerged over the last decades as one of the most powerful techniques for identifying starting chemical matter to target specific proteins or nucleic acids in vitro. However, the use of such lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f95ea52cd1b9e6547f5e3c06e7b81
https://pubmed.ncbi.nlm.nih.gov/34699722
https://pubmed.ncbi.nlm.nih.gov/34699722
Autor:
Yiming Cai, Maya Modak, Sebastian Weigang, Emmie de Wit, Jean K. Lim, Alistair Dunham, Benjamin J. Polacco, Qiongyu Li, Svenja Ulferts, Gwendolyn M. Jang, Aurelien Dugourd, David E. Gordon, Jeffrey Z. Guo, Kirsten Obernier, Sophia Bouhaddou, Elizabeth R. Fischer, Anna Gaulton, Jason C.J. Chang, Bjoern Meyer, Diego Quintero, Julian Knerr, Trupti Patil, Emma J. Manners, Michael C. O’Neal, Monita Muralidharan, Joseph Hiatt, Ajda Rojc, James E. Melnyk, Tanja Kortemme, Benjamin R. tenOever, Thomas Vallet, Rémy Robinot, Cassandra Koh, Benjamin E. Nilsson-Payant, Ruth Hüttenhain, Saker Klippsten, Alicia L. Richards, Eloy Felix, Brian K. Shoichet, Beril Tutuncuoglu, Danielle L. Swaney, Veronica V. Rezelj, Jeffery R. Johnson, Margaret Soucheray, Marisa Goff, R. Dyche Mullins, Kris M. White, Erica Stevenson, Jyoti Batra, Christopher J.P. Mathy, Yuan Zhou, Minkyu Kim, Marco Vignuzzi, Claudia Hernandez-Armenta, Kevan M. Shokat, Julio Saez-Rodriguez, Jacqueline M. Fabius, Timothy McBride, Adolfo García-Sastre, Quang Dinh Tran, Alexandra Hardy, Elena Moreno, Alberto Valdeolivas, Mehdi Bouhaddou, Andrew R. Leach, Melanie Ott, Georg Kochs, Pedro Beltrao, Jiewei Xu, Robyn M. Kaake, Merve Cakir, Ying Shi, Nevan J. Krogan, Lisa Miorin, Danish Memon, David J. Broadhurst, Miguel Correa Marrero, Robert Grosse
Publikováno v:
Cell
Cell, vol 182, iss 3
Cell, Elsevier, 2020, 182, pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, 2020, 182 (3), pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, vol 182, iss 3
Cell, Elsevier, 2020, 182, pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, 2020, 182 (3), pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Summary The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3a4ccf1bdc8c22239cad9f79ccc506
http://europepmc.org/articles/PMC7321036
http://europepmc.org/articles/PMC7321036
Autor:
Borazjani, Nassim, Sepehri, Saghi, Behzadi, Maryam, Jarrahpour, Aliasghar, Rad, Javad Ameri, Sasanipour, Maryam, Mohkam, Milad, Ghasemi, Younes, Akbarizadeh, Amin Reza, Digiorgio, Carole, Brunel, Jean Michel, Ghanbari, Mohammad Mehdi, Batta, Gyula, Turos, Edward
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Frontiers, 2019, 10, pp.1041. ⟨10.3389/fgene.2019.01041⟩
Frontiers in Genetics, 2019, 10, pp.1041. ⟨10.3389/fgene.2019.01041⟩
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics, Frontiers, 2019, 10, pp.1041. ⟨10.3389/fgene.2019.01041⟩
Frontiers in Genetics, 2019, 10, pp.1041. ⟨10.3389/fgene.2019.01041⟩
Frontiers in Genetics, Vol 10 (2019)
International audience; To address the problem of resistance to paclitaxel treatment, we have investigated to which extent is possible to predict Breast Cancer (BC) patient response to this drug. We carried out a large-scale tumor-based prediction an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d81701868d5035783524f1a17bb0f68
https://hal.archives-ouvertes.fr/hal-02511536
https://hal.archives-ouvertes.fr/hal-02511536
Autor:
Malgorzata N. Drwal, Esther Kellenberger, Célien Jacquemard, Didier Rognan, Viet-Khoa Tran-Nguyen
Publikováno v:
Molecules
Molecules, MDPI, 2019, 24 (14), ⟨10.3390/molecules24142610⟩
Volume 24
Issue 14
Molecules, MDPI, 2019, 24 (14), pp.2610. ⟨10.3390/molecules24142610⟩
Molecules, Vol 24, Iss 14, p 2610 (2019)
Molecules, MDPI, 2019, 24 (14), ⟨10.3390/molecules24142610⟩
Volume 24
Issue 14
Molecules, MDPI, 2019, 24 (14), pp.2610. ⟨10.3390/molecules24142610⟩
Molecules, Vol 24, Iss 14, p 2610 (2019)
International audience; Ligand docking at a protein site can be improved by prioritizing poses by similarity to validated binding modes found in the crystal structures of ligand/protein complexes. The interactions formed in the predicted model are se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31350f57acaac8fb4ee937e1455cf123
https://hal.archives-ouvertes.fr/hal-03021606
https://hal.archives-ouvertes.fr/hal-03021606
Publikováno v:
MSphere
MSphere, American Society for Microbiology., 2019, 4 (3), pp.e00282-19. ⟨10.1128/mSphere.00282-19⟩
mSphere, Vol 4, Iss 3, p e00282-19 (2019)
MSphere, 2019, 4 (3), pp.e00282-19. ⟨10.1128/mSphere.00282-19⟩
mSphere
mSphere, Vol 4, Iss 3 (2019)
MSphere, American Society for Microbiology., 2019, 4 (3), pp.e00282-19. ⟨10.1128/mSphere.00282-19⟩
mSphere, Vol 4, Iss 3, p e00282-19 (2019)
MSphere, 2019, 4 (3), pp.e00282-19. ⟨10.1128/mSphere.00282-19⟩
mSphere
mSphere, Vol 4, Iss 3 (2019)
Inhalational anthrax caused by Bacillus anthracis, a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c093bbceed8f17d495afe8d705aaa92
https://hal-pasteur.archives-ouvertes.fr/pasteur-03293178/file/mSphere.00282-19.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03293178/file/mSphere.00282-19.pdf
Publikováno v:
médecine/sciences
médecine/sciences, EDP Sciences, 2017, 33 (5), pp.478-480. ⟨10.1051/medsci/20173305006⟩
médecine/sciences, 2017, 33 (5), pp.478-480. ⟨10.1051/medsci/20173305006⟩
médecine/sciences, EDP Sciences, 2017, 33 (5), pp.478-480. ⟨10.1051/medsci/20173305006⟩
médecine/sciences, 2017, 33 (5), pp.478-480. ⟨10.1051/medsci/20173305006⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d82661f82ffde8b278b624b6230630
https://doi.org/10.1051/medsci/20173305006
https://doi.org/10.1051/medsci/20173305006
Autor:
Imen Bassoumi-Jamoussi, Guillaume Bouvier, Michael Nilges, Mourad Barhoumi, N. Kyle Tanner, Josette Banroques, Arnaud Blondel, Ikram Guizani, Nathan Desdouits, Khadija Essafi-Benkhadir, Hélène Munier-Lehmann, Emna Harigua-Souiai, Yosser Zina Abdelkrim, Ons Zakraoui
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0672f598131f3a814de19e5a2c66f228
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424
Autor:
Florence Boisgerault, Federico Mingozzi, Romain Hardet, Helena Costa Verdera, Giuseppe Ronzitti, Alicia M. Michaud, Fanny Collaud, Amine Meliani, Giorgia Manni, Severine Charles, Alban Vignaud, Christian Leborgne, Petr Ilyinskii, Takashi Kei Kishimoto, Marcelo Simon Sola, Francesca Fallarino, Olivier D. Christophe, Solenne Marmier, Christopher J. Roy, Laetitia van Wittenberghe
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Gene therapy mediated by recombinant adeno-associated virus (AAV) vectors is a promising treatment for systemic monogenic diseases. However, vector immunogenicity represents a major limitation to gene transfer with AAV vectors, particularly for vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e609f78e07de4ba083e8423956027be
http://hdl.handle.net/11391/1439292
http://hdl.handle.net/11391/1439292
Autor:
François Tillequin, Soizic Prado, Michel Koch, Brigitte Saint-Joanis, Yves L. Janin, Stewart T. Cole, Priscille Brodin, Pierre-Etienne Bost, Sylvie Michel
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2007, 15 (5), pp.2177-86. ⟨10.1016/j.bmc.2006.12.009⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 (5), pp.2177-86. 〈10.1016/j.bmc.2006.12.009〉
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 (5), pp.2177-86. ⟨10.1016/j.bmc.2006.12.009⟩
Bioorganic and Medicinal Chemistry, 2007, 15 (5), pp.2177-86. ⟨10.1016/j.bmc.2006.12.009⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 (5), pp.2177-86. 〈10.1016/j.bmc.2006.12.009〉
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 (5), pp.2177-86. ⟨10.1016/j.bmc.2006.12.009⟩
International audience; We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Myc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca64607b419543bcb45a6a01c601c91
https://doi.org/10.1016/j.bmc.2006.12.009
https://doi.org/10.1016/j.bmc.2006.12.009
Autor:
Jean-Gérard Guillet, Bernard Maillere, Sandra Pouvelle-Moratille, Mathieu Surenaud, Hanne Gahery, Lucie Ourth, Catherine Texier, Céline Igea, Suzanne Figueiredo
Publikováno v:
AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (3), pp.427-37. ⟨10.1089/aid.2006.0075⟩
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (3), pp.427-37. 〈10.1089/aid.2006.0075〉
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (3), pp.427-37. ⟨10.1089/aid.2006.0075⟩
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (3), pp.427-37. 〈10.1089/aid.2006.0075〉
International audience; We screened the Neflaiprotein to identify new HLA-DR-restricted epitopes, because this small protein is expressed early during infection, and specific CD4(+) T cells are critical for effective immunity in HIV-1 infection. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22366f071b56956848646f0c8f962fda
https://doi.org/10.1089/aid.2006.0075
https://doi.org/10.1089/aid.2006.0075