A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery

Autor: Sabrina Boulet, Mathias Pessiglione, Caroline Jan, Dominique Tandé, Léon Tremblay, Stéphanie Mounayar, Marc Savasta, Etienne C. Hirsch, Chantal François, Jean Féger

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2007, 130 (Pt 11), pp.2898-914. ⟨10.1093/brain/awm208⟩
Brain-A Journal of Neurology, 2007, 130 (Pt 11), pp.2898-914. ⟨10.1093/brain/awm208⟩

International audience; The cardinal symptoms in Parkinson's disease (PD), akinesia, rigidity and tremor, are only observed when the striatal level of dopamine is decreased by 60-80%. During the preclinical phase of PD, compensatory mechanisms are pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2e74e2f5302e3418899a553e46c599
https://doi.org/10.1093/brain/awm208

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.: New Anti-Dyskinetic Treatment for PD

Autor: Aron Badin, Romina, Spinnewyn, Brigitte, Gaillard, Marie-Claude, Jan, Caroline, Malgorn, Carole, van Camp, Nadja, Dollé, Frédéric, Guillermier, Martine, Boulet, Sabrina, Bertrand, Anne, Savasta, Marc, Auguet, Michel, Brouillet, Emmanuel, Chabrier, Pierre-Etienne, Hantraye, Philippe

Publikováno v: PLoS ONE
PLoS ONE, 2013, 8 (1), pp.e52680. ⟨10.1371/journal.pone.0052680⟩

International audience; The development of dyskinesias following chronic L-DOPA replacement therapy remains a major problem in the long-term treatment of Parkinson's disease. This study aimed at evaluating the effect of IRC-082451 (base of BN82451),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::4950abb110b169e4d11b715fa6bac069
https://www.hal.inserm.fr/inserm-00857944

Opposing effects of dopamine D2 receptor stimulation on the spontaneous and the electrically evoked release of [3H]gaba on rat prefrontal cortex slices

Autor: J. Penit-Soria, Marie-Jo Besson, S. Retaux

Publikováno v: Neuroscience
Neuroscience, 1991, 42 (1), pp.61-71. ⟨10.1016/0306-4522(91)90150-m⟩

International audience; The spontaneous and the electrically evoked release of [3H]GABA were studied in vitro on slices of rat medial prefrontal cortex. The slices were preincubated with [3H]GABA and then superfused with a Krebs' solution. The superf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83c569730f4e06912cd1db313faaafd
https://doi.org/10.1016/0306-4522(91)90150-m

Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats

Autor: Emily F. M. Fitzpatrick, Keyoumars Ashkan, John Mitrofanis, Bradley A. Wallace, Alim-Louis Benabid

Publikováno v: Anatomy and Embryology
Anatomy and Embryology, Springer Verlag, 2005, 210 (2), pp.101-23. ⟨10.1007/s00429-005-0003-y⟩

International audience; We explore the patterns of survival among dopaminergic cells of the midbrain in MPTP-treated macaque monkeys and 6OHDA-lesioned Sprague-Dawley rats. For the monkeys, animals were injected intramuscularly with MPTP for 8 days c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdbf6505d1ebe71f911fc0a9fab5f0e
https://www.hal.inserm.fr/inserm-00391001

Inhibition of nigral dopamine neurons by systemic and local apomorphine: Possible contribution of dendritic autoreceptors

Autor: Claude Saunier, Guy Chouvet, Hideo Akaoka, Michel Buda, P. J. Charlety

Publikováno v: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 1992, 49 (4), pp.879-891. ⟨10.1016/0306-4522(92)90364-8⟩

International audience; Peripheral administration of low doses of dopamine agonist apomorphine induces a strong and short-latency inhibition of dopamine neurons in the substantia nigra, presumably via the activation of somatodendritic autoreceptors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01a93167c9f7fa8bc63a5071707d353
https://hal.archives-ouvertes.fr/hal-03066885