Výsledky vyhledávání - "MESH: Disease Susceptibility"

Identification of adipocytes as target cells for Leishmania infantum parasites

Autor: Schwing, Aurélie, Pisani, Didier, Pomares, Christelle, Majoor, Alissa, Lacas-Gervais, Sandra, Jager, Jennifer, Lemichez, Emmanuel, Marty, Pierre, Boyer, Laurent, Michel, Grégory

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11 (1), pp.21275. ⟨10.1038/s41598-021-00443-y⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

International audience; Leishmania infantum is the causative agent of visceral leishmaniasis transmitted by the bite of female sand flies. According to the WHO, the estimated annual incidence of leishmaniasis is one million new cases, resulting in 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d40324873466a431fa9416398403f539
https://hal-pasteur.archives-ouvertes.fr/pasteur-03744940

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Bidirectional sensory neuron–immune interactions: a new vision in the understanding of allergic inflammation

Autor: Brian S. Kim, Marie Tauber, Nicolas Gaudenzio, Fang Wang

Publikováno v: Current Opinion in Immunology
Current Opinion in Immunology, 2021, 72, pp.79-86. ⟨10.1016/j.coi.2021.03.012⟩

International audience; Peripheral neurons (including sensory neurons) are ubiquitously distributed in all tissues, particularly at the interface with the environment. The primary function of sensory neurons is the transmission of sensations of tempe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2bf0c3b78242fa23a596b79d7f0014
https://ut3-toulouseinp.hal.science/hal-03663632

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Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis

Autor: Florence Jeny, Jean-François Bernaudin, Dominique Valeyre, Marianne Kambouchner, Marina Pretolani, Hilario Nunes, Carole Planès, Valérie Besnard

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, 2021, 12, pp.719009. ⟨10.3389/fimmu.2021.719009⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.719009. ⟨10.3389/fimmu.2021.719009⟩

BackgroundMacrophages are pivotal cells in sarcoidosis. Monocytes-derived (MD) macrophages have recently been demonstrated to play a major role especially in pulmonary sarcoidosis. From inflammatory tissues to granulomas, they may be exposed to low o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df147dc9914b12fd62b733cb5a1900dc
https://doi.org/10.3389/fimmu.2021.719009

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Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis

Autor: Marie Maumus, Pauline Rozier, Florence Sabatier, Danièle Noël, Alexandre Thibault Jacques Maria, Christian Jorgensen, Claire Bony, Philippe Guilpain

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6837, p 6837 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, 2021, 22 (13), pp.6837. ⟨10.3390/ijms22136837⟩

International audience; Systemic sclerosis (SSc) is a complex disorder resulting from dysregulated interactions between the three main pathophysiological axes: fibrosis, immune dysfunction, and vasculopathy, with no specific treatment available to da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6894dd507ed8d6a067531aa142515b1c
https://www.mdpi.com/1422-0067/22/13/6837

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Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (12), pp.e2005753118. ⟨10.1073/pnas.2005753118⟩

Kleine-Levin syndrome (KLS) is a rare disorder characterized by severe episodic hypersomnia, with cognitive impairment accompanied by apathy or disinhibition. Pathophysiology is unknown, although imaging studies indicate decreased activity in hypotha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a628f3bc4473a79bda8966a1c1b669c7
https://doi.org/10.1073/pnas.2005753118

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Linking neuroinflammation to motor neuron degeneration in ALS: The critical role of CXCL13/CXCR5

Autor: Alizée Arnoux, Luc Dupuis

Publikováno v: EBioMedicine
EBioMedicine, 2021, 63, pp.103149. ⟨10.1016/j.ebiom.2020.103149⟩
EBioMedicine, Elsevier, 2021, 63, pp.103149. ⟨10.1016/j.ebiom.2020.103149⟩
EBioMedicine, Vol 63, Iss, Pp 103149-(2021)

International audience; No abstract available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c57802587c1885c60980e176351399
https://www.hal.inserm.fr/inserm-03376322/file/1-s2.0-S2352396420305259-main.pdf

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Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Autor: Chandini Bhaskar Naidu, Joanna Timmins, Fabienne Hans, Muge Senarisoy

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9226, p 9226 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (23), pp.9226. ⟨10.3390/ijms21239226⟩
International Journal of Molecular Sciences, 2020, 21 (23), pp.9226. ⟨10.3390/ijms21239226⟩

International audience; Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe damage to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ab3aa7711b687ca486c60dd62a3c6
https://www.mdpi.com/1422-0067/21/23/9226

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Different populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) from Central Africa are susceptible to Zika virus infection

Autor: Aurelie P. Yougang, Theodel A. Wilson-Bahun, Marie Vazeille, Armel N. Tedjou, Basile Kamgang, Laurence Mousson, Anna-Bella Failloux, Charles S. Wondji

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008163 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2020, 14 (3), pp.e0008163. ⟨10.1371/journal.pntd.0008163⟩
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (3), pp.e0008163. ⟨10.1371/journal.pntd.0008163⟩

Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baeaca70c5871d995f241e6f8c6688a
https://doaj.org/article/dd7fba3000b24d8aa3190ab9d1a27086

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Using Serology to Anticipate Measles Post-honeymoon Period Outbreaks

Autor: Angela R. McLean, Amy Wesolowski, Justin Lessler, William J. Moss, C. J.E. Metcalf, Bryan T. Grenfell, Amy Winter, Simon Cauchemez

Publikováno v: Trends in Microbiology
Trends in Microbiology, Elsevier, 2020, 28 (8), pp.597-600. ⟨10.1016/j.tim.2020.04.009⟩
Trends in Microbiology, 2020, 28 (8), pp.597-600. ⟨10.1016/j.tim.2020.04.009⟩

International audience; Measles vaccination is a public health 'best buy', with the highest cost of illness averted of any vaccine-preventable disease (Ozawa et al., Bull. WHO 2017;95:629). In recent decades, substantial reductions have been made in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b628db158e16b081fb6878f7ed9bd3
https://pubmed.ncbi.nlm.nih.gov/32359782

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Differentiation-dependent susceptibility of human muscle cells to Zika virus infection

Autor: Gillian Butler-Browne, Jim Zoladek, Ingo Riederer, Quentin Giai Gianetto, Philippe Roingeard, Patricia Jeannin, Julien Burlaud-Gaillard, Pierre-Emmanuel Ceccaldi, Mariette Matondo, Valérie Choumet, Thibault Chaze, Vincent Legros, Vincent Mouly, Philippe V. Afonso, Antoine Gessain, Mariela-Natacha Gonzàlez

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (8), pp.e0008282. ⟨10.1371/journal.pntd.0008282⟩
PLoS Neglected Tropical Diseases, 2020, 14 (8), pp.e0008282. ⟨10.1371/journal.pntd.0008282⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008282 (2020)
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14, ⟨10.1371/journal.pntd.0008282⟩

Muscle cells are potential targets of many arboviruses, such as Ross River, Dengue, Sindbis, and chikungunya viruses, that may be involved in the physiopathological course of the infection. During the recent outbreak of Zika virus (ZIKV), myalgia was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae776d91cb415f518bbec3e604af2555
https://hal.sorbonne-universite.fr/hal-02939106/file/journal.pntd.0008282.pdf

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