Gene activation precedes DNA demethylation in response to infection in human dendritic cells

Autor: Anne Dumaine, Luis B. Barreiro, Ludovic Tailleux, Florence Mailhot-Léonard, Haley E. Randolph, Alain Pacis, Jean-Christophe Grenier, Vania Yotova

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩

Significance Immune response to infection is accompanied by active demethylation of thousands of CpG sites. Yet, the causal relationship between changes in DNA methylation and gene expression during infection remains to be elucidated. Here, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d1ec2f5b67bee7e15b2a518a09f484
http://europepmc.org/articles/PMC6452747

Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood

Autor: Antoine Blancher, Sandrine Sourdet, Nicolas Congy-Jolivet, Kevin Guedj, Francis Roubinet, Bénédicte Puissant-Lubrano, Fati Nourhashemi, Sophie Guyonnet, Pol André Apoil

Publikováno v: Immunology and Cell Biology
Immunology and Cell Biology, Nature Publishing Group, 2018, 96 (1), pp.114-120. ⟨10.1111/imcb.1004⟩

International audience; We analyzed the impact of age, sex, and CMV on blood monocyte and dendritic cell (DC) subpopulations in 256 healthy individuals aged from 19 to 96 years. Flow cytometry was performed on whole blood within the 4 h following blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae522a83d91a18d53b482b59de11cf8
https://doi.org/10.1111/imcb.1004

Toxoplasma and Dendritic Cells: An Intimate Relationship That Deserves Further Scrutiny

Autor: Poncet, Anaïs F., Blanchard, Nicolas, Marion, Sabrina

Publikováno v: Trends in Parasitology
Trends in Parasitology, 2019, 35, pp.870-886. ⟨10.1016/j.pt.2019.08.001⟩

International audience; Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to favor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4254::b985491b156baebfc55ec0e40d73bfda
https://hal.science/hal-03489052/file/S1471492219302107.pdf

Nonspecific CD8 + T Cells and Dendritic Cells/Macrophages Participate in Formation of CD8 + T Cell-Mediated Clusters against Malaria Liver-Stage Infection

Autor: Katsuyuki Yui, Rogerio Amino, Daisuke Kimura, Masoud Akbari, Kazumi Kimura, Ganchimeg Bayarsaikhan, Masao Yuda, Smriti Juriasingani, Mana Miyakoda

Publikováno v: Infection and Immunity
Infection and Immunity, 2018, 86 (4), pp.e00717-17. ⟨10.1128/IAI.00717-17⟩
Infection and Immunity, American Society for Microbiology, 2018, 86 (4), pp.e00717-17. ⟨10.1128/IAI.00717-17⟩

CD8+ T cells are the major effector cells that protect against malaria liverstage infection, forming clusters around Plasmodium-infected hepatocytes and eliminating parasites after a prolonged interaction with these hepatocytes. We aimed to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06d578c979db06c4794fc58a55c3d3f
https://hal-pasteur.archives-ouvertes.fr/pasteur-02425464

Actin’ on HIV: How Dendritic Cells Spread Infection

Autor: Daniel A. Donahue, Olivier Schwartz

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2016, 19 (3), pp.267-269. ⟨10.1016/j.chom.2016.02.016⟩
Cell Host and Microbe, 2016, 19 (3), pp.267-269. ⟨10.1016/j.chom.2016.02.016⟩

Whereas human dendritic cells (DCs) are largely resistant to productive infection with HIV-1, they have a unique ability to take up the virus and transmit it efficiently to T lymphocytes through a process of trans-infection or trans-enhancement. To e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc223c460f63b9a8d19d4c8e9d0288d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372388