Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

Autor: Sandrine Rosario, Jérôme Loc’h, Marc Delarue

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩
Structure, 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩

International audience; Eukaryotic DNA polymerase of the polX family, such as pol μ and terminal deoxynucleotidyl transferase (TdT), are key components of the non-homologous end-joining or V(D)J recombination machinery, respectively. The established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25dce4551e4d792e5f10e9f943fbe26
https://pubmed.ncbi.nlm.nih.gov/27499438

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target

Autor: Roberta Costi, Luca Pescatori, Jerome Gouge, Pietro Campiglia, Bruno Maresca, Giuliana Cuzzucoli Crucitti, Marc Delarue, Luigi Scipione, Giovanni Maga, Ettore Novellino, Antonella Messore, Silvano Tortorella, Ilaria Granata, Amalia Porta, Roberto Di Santo, Alessandra Amoroso, Emmanuele Crespan

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (18), pp.7431-41. ⟨10.1021/jm4010187⟩
Journal of Medicinal Chemistry, 2013, 56 (18), pp.7431-41. ⟨10.1021/jm4010187⟩

International audience; Terminal deoxynucletidyl transferase (TdT) is overexpressed in some cancer types, where it might compete with pol μ during the mutagenic repair of double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa3bc33ee529fa4d472ad0e92512bad
https://pubmed.ncbi.nlm.nih.gov/23968551

Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells

Autor: Thierry Kortulewski, Pierre Vaigot, Pascal Soularue, Olivier Alibert, Alexandre Pawlik, Diana Tronik-Le Roux, Beatrice Jacquelin, Xavier Gidrol, Christophe Joubert, Gaëtan Gruel

Publikováno v: Blood
Blood, 2005, 106 (6), pp.1965-1974. ⟨10.1182/blood-2004-10-3975⟩
Blood, American Society of Hematology, 2005, 106 (6), pp.1965-1974. ⟨10.1182/blood-2004-10-3975⟩

Our knowledge of the molecular mechanisms that regulate hematopoiesis in physiologic and pathologic conditions is limited. Using a molecular approach based on cDNA microarrays, we demonstrated the emergence of an alternative pathway for mature bone m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1baebfd8aadf84afd6872961147eda
https://hal-pasteur.archives-ouvertes.fr/pasteur-02618902

Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo

Autor: Annie De Smet, Barbara Bertocci, Claude-Agnès Reynaud, Jean-Claude Weill

Publikováno v: Immunity
Immunity, Elsevier, 2006, 25 (1), pp.31-41. 〈10.1016/j.immuni.2006.04.013〉
Immunity, 2006, 25 (1), pp.31-41. ⟨10.1016/j.immuni.2006.04.013⟩
Immunity, Elsevier, 2006, 25 (1), pp.31-41. ⟨10.1016/j.immuni.2006.04.013⟩

International audience; DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We showed previously that pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0863edf51d64c4de759f0c53a09d195a