Zobrazeno 1 - 10 of 11 pro vyhledávání: '"MESH: DNA End-Joining Repair"'
1
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination
Autor: Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano
Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩
Funder: Ligue Nationale Contre le Cancer
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552ddce6e8fcc03619460c08b3e7d7a
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2
Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ
Autor: Loelia Babin, Caroline Demangel, Hélène Lenden-Hasse, Ludovic Deriano, Ludivine Baron, Erika Brunet, José Yélamos, Marie Bedora-Faure, Wei Yu, Chloé Lescale
Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5239. ⟨10.1038/s41467-020-19060-w⟩
Nature Communications, 2020, 11 (1), pp.5239. ⟨10.1038/s41467-020-19060-w⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand break (DSB) repair in cells deficient for NHEJ or homologous recombination, suggesting that it operates at all stages of the cell cycle. Here, we use an approach in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3732515aa216a36cf4ec687e59a5511b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03262335/document
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3
Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions
Autor: Wilhelm Vaysse-Zinkhöfer, David Viterbo, Stéphane Descorps-Declère, Lucie Poggi, Guy-Franck Richard, Valentine Mosbach
Publikováno v: PLoS Genetics, Vol 16, Iss 7, p e1008924 (2020)
PLoS Genetics
PLoS Genetics, 2020, 16 (7), pp.e1008924. ⟨10.1371/journal.pgen.1008924⟩
Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af72aaff1c19e94d418813f2ccf2888e
https://doaj.org/article/4d98239c049246cda0811bc9d615a42e
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4
Regulatory control of DNA end resection by Sae2 phosphorylation
Autor: Cannavo, Elda, Johnson, Dominic, Andres, Sara, Kissling, Vera, Reinert, Julia, Garcia, Valerie, Erie, Dorothy, Hess, Daniel, Thomä, Nicolas, Enchev, Radoslav, Peter, Matthias, Williams, R Scott, Neale, Matt, Cejka, Petr, Williams, R. Scott
Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4016. ⟨10.1038/s41467-018-06417-5⟩
Nature Communications, 2018, 9 (1), pp.4016. ⟨10.1038/s41467-018-06417-5⟩
DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ea14620727e476ba950feae2b28f8280
https://hal.archives-ouvertes.fr/hal-02404052
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5
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
Autor: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
Publikováno v: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
International audience; BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4
https://www.repository.cam.ac.uk/handle/1810/282947
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6
PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection
Autor: Janet Hall, Bernard S. Lopez, Josée Guirouilh-Barbat, Alexis Fouquin, Vincent Pennaneach, Mounira Amor-Guéret
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (21), pp.12325-12339. ⟨10.1093/nar/gkx881⟩
International audience; Double strand breaks (DSBs) are one of the most toxic lesions to cells. DSB repair by the canonical non-homologous end-joining (C-EJ) pathway involves minor, if any, processing of the broken DNA-ends, whereas the initiation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5abc9bb1744600b8da7d900349c0149
https://hal.archives-ouvertes.fr/hal-03048269
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7
Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination
Autor: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy, Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic
Publikováno v: Journal of Immunological Methods
Journal of Immunological Methods, Elsevier, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩
Journal of Immunological Methods, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩
International audience; Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4dd926b4108c0406ce78aed8afe218f
https://hal-pasteur.archives-ouvertes.fr/pasteur-03271165/file/1-s2.0-S0022175917303447-main.pdf
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8
Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex
Autor: David C. Schriemer, Cortt G. Piett, Michael Weinfeld, J. N. Mark Glover, Shujuan Fang, Ruiqiong Ye, John A. Tainer, Ross A. Edwards, Zahra Havali-Shahriari, R. Daniel Aceytuno, Fatima Javed, Rajam S. Mani, Martial Rey, Michal Hammel, Susan P. Lees-Miller
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (10), pp.6238-6251. ⟨10.1093/nar/gkx275⟩
International audience; Non-homologous end joining (NHEJ) repairs DNA double strand breaks in non-cycling eukaryotic cells. NHEJ relies on polynucleotide kinase/phosphatase (PNKP), which generates 5΄-phosphate/3΄-hydroxyl DNA termini that are criti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865e84a730a59a99bb19d1b2f6d7322
https://hal.archives-ouvertes.fr/hal-03014077
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9
Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice
Autor: Heng-Kuan Wong, Françoise Dantzer, Valérie Schreiber, Aurélia Noll, Bernardo Reina-San-Martin, José Yélamos, Léa Gaudot, Isabelle Robert
Publikováno v: Eur J Immunol
Eur J Immunol, 2017, 47 (4), pp.665-676. ⟨10.1002/eji.201646757⟩
To mount highly specific and adapted immune responses, B lymphocytes assemble and diversify their antibody repertoire through mechanisms involving the formation of programmed DNA damage. Immunoglobulin class switch recombination (CSR) is triggered by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3a2de51cecef0a8af35091ee7c1401
https://hal.archives-ouvertes.fr/hal-02369971
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10
RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'
Autor: Vered Gigi, Martina Mijušković, Wenzhao Meng, David Roth, Eline T. Luning Prak, Ludovic Deriano, Susanna M. Lewis, Olga Shestova
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (10), pp.6352-64. ⟨10.1093/nar/gku295⟩
Nucleic Acids Research, 2014, 42 (10), pp.6352-64. ⟨10.1093/nar/gku295⟩
International audience; DNA double-stranded breaks (DSBs) can be repaired by several mechanisms, including classical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ (a-NHEJ). How cells choose between these alternatives
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670ca871dc27dd795c7ad156b3b7801e
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/file/gku295.pdf
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