Výsledky vyhledávání - "MESH: DNA Damage/genetics"

Two dechlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower proangiogenic properties compared to the parent compound

Autor: Sébastien Bristeau, Sébastien Faure, Samuel Legeay, Pierre-André Billat, Christophe Mouvet, Nicolas Clere, Fabrice Nesslany

Publikováno v: Environmental Science and Pollution Research
Environmental Science and Pollution Research, 2018, 25 (15), pp.14313-14323. ⟨10.1007/s11356-017-8592-6⟩
Environmental Science and Pollution Research, Springer Verlag, 2018, 25 (15), pp.14313-14323. ⟨10.1007/s11356-017-8592-6⟩

International audience; Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ac4a59044be7b7e8bffe9c6e89c23f
https://pubmed.ncbi.nlm.nih.gov/28210952

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DNA damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes Running title: DNA damage and p53 in obese adipocytes

Autor: Vergoni, Bastien, Cornejo, Pierre-Jean, Gilleron, Jérôme, Dedjani, Mansour, Ceppo, Franck, Jacquel, Arnaud, Bouget, Gwennaelle, Ginet, Clémence, Gonzalez, Teresa, Maillet, Julie, Dhennin, Véronique, Verbanck, Marie, Auberger, Patrick, Froguel, Philippe, Tanti, Jean-François, Cormont, Mireille

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2016, 65 (10), pp.3062-3074. ⟨10.2337/db16-0014⟩
Diabetes, 2016, 65 (10), pp.3062-3074. ⟨10.2337/db16-0014⟩

International audience; Activation of the p53 pathway in adipose tissue contributes to insulin resistance associated with obesity. However, the mechanisms of p53 activation and the impact on adipocyte functions are still elusive. Here we found a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9c8b20bbd82ba41801276eb174839a70
https://www.hal.inserm.fr/inserm-01345698

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