SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

Autor: Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩

Funder: Ligue Nationale Contre le Cancer
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552ddce6e8fcc03619460c08b3e7d7a

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair

Autor: de Krijger, Inge, Föhr, Bastian, Pérez, Santiago Hernández, Vincendeau, Estelle, Serrat, Judit, Thouin, Alexander Marc, Susvirkar, Vivek, Lescale, Chloé, Paniagua, Inés, Hoekman, Liesbeth, Kaur, Simranjeet, Altelaar, Maarten, Deriano, Ludovic, Faesen, Alex C, Jacobs, Jacqueline J L, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25724-y⟩

MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it controls DNA repair pathway choice by counteracting DNA end-resection. Here we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0eef28d1f10f82de63f851b152c960
https://hdl.handle.net/21.11116/0000-000A-7D73-921.11116/0000-000A-7D6F-F

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions

Autor: Wilhelm Vaysse-Zinkhöfer, David Viterbo, Stéphane Descorps-Declère, Lucie Poggi, Guy-Franck Richard, Valentine Mosbach

Publikováno v: PLoS Genetics, Vol 16, Iss 7, p e1008924 (2020)
PLoS Genetics
PLoS Genetics, 2020, 16 (7), pp.e1008924. ⟨10.1371/journal.pgen.1008924⟩

Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af72aaff1c19e94d418813f2ccf2888e
https://doaj.org/article/4d98239c049246cda0811bc9d615a42e

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Autor: Glover, Lucy, Marques, Catarina A., Suska, Olga, Horn, David

Publikováno v: mBio
mBio, American Society for Microbiology, 2019, 10 (4), pp.e01252-19. ⟨10.1128/mBio.01252-19⟩
mBio, Vol 10, Iss 4, p e01252-19 (2019)
mBio, Vol 10, Iss 4 (2019)

Chromosome damage must be repaired to prevent the proliferation of defective cells. Alternatively, cells with damage must be eliminated. This is true of human and several other cell types but may not be the case for single-celled parasites, such as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::caa46167e05a82d5322cc74853814b72
https://hal-pasteur.archives-ouvertes.fr/pasteur-03107118/file/mBio-2019-Glover-e01252-19.full.pdf

Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy

Autor: Valentine Mosbach, Lucie Poggi, Guy-Franck Richard

Publikováno v: Current Genetics
Current Genetics, 2019, 65, pp.17-28. ⟨10.1007/s00294-018-0865-1⟩
Current Genetics, Springer Verlag, 2019, 65, pp.17-28. ⟨10.1007/s00294-018-0865-1⟩

International audience; Trinucleotide repeats are a particular class of microsatellites whose large expansions are responsible for at least two dozen human neurological and developmental disorders. Slippage of the two complementary DNA strands during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a044ea1af10f5dd5095ad5e06bfa6f5
https://hal-pasteur.archives-ouvertes.fr/pasteur-02864590