Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice

Autor: Mas-Orea, Xavier, Sebert, Morgane, Benamar, Mehdi, Petitfils, Camille, Blanpied, Catherine, Saoudi, Abdelhadi, Deraison, Céline, Barreau, Frederick, Cenac, Nicolas, Dietrich, Gilles

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (14), 14 p. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, 2021, 22 (14), pp.7387. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, Vol 22, Iss 7387, p 7387 (2021)
Volume 22
Issue 14

Mucosal CD4+ T lymphocytes display a potent opioid-mediated analgesic activity in interleukin (IL)-10 knockout mouse model of inflammatory bowel diseases (IBD). Considering that endogenous opioids may also exhibit anti-inflammatory activities in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bb134bb86675ea8d3653c20775f79e70
https://hal.inrae.fr/hal-03330200/document

Effector memory CD8 T cell response elicits Hepatitis E Virus genotype 3 pathogenesis in the elderly

Autor: El Costa, Hicham, Gouilly, Jordi, Abravanel, Florence, Bahraoui, Elmostafa, Peron, Jean-Marie, Kamar, Nassim, Jabrane-Ferrat, Nabila, Izopet, Jacques

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2021, 17 (2), pp.e1009367. ⟨10.1371/journal.ppat.1009367⟩
PLoS Pathogens, Vol 17, Iss 2, p e1009367 (2021)
PLoS Pathogens, 2021, 17 (2), pp.e1009367. ⟨10.1371/journal.ppat.1009367⟩

Genotype 3 Hepatitis E virus (HEV-3) is an emerging threat for aging population. More than one third of older infected patients develops clinical symptoms with severe liver damage, while others remain asymptomatic. The origin of this discrepancy is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7412492dbc6ea643e5322c2b01300e0d
http://europepmc.org/articles/PMC7932504

Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals

Autor: Guillaume Martin-Blondel, Jacques Izopet, Mary Requena, Bertrand Suc, Laurent Alric, Manon Nayrac, Nicolas Carrere, Pierre Delobel, Karl Barange, Claire Loiseau, Michelle Cazabat

Publikováno v: Mucosal Immunology
Mucosal Immunology, 2020, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩
Mucosal Immunology, Nature Pub. Group, 2021, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩

International audience; Gut CD4+ T cells are incompletely restored in most HIV-1-infected individuals on antiretroviral therapy, notably Th17 cells, a key subset in mucosal homeostasis. By contrast, gut Th22 cells are usually restored at normal frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7063cc54ac3d26c97d0c23435a80444c
https://ut3-toulouseinp.hal.science/hal-03157449

Increased CXCR3+ T Cells Impairs Recruitment of T-Helper Type 17 Cells via Interferon γ and Interleukin 18 in the Small Intestine Mucosa During Treated HIV-1 Infection

Autor: Nicolas Carrere, Jacques Izopet, Bertrand Suc, Claire Loiseau, Michelle Cazabat, Pierre Delobel, Mary Requena, Manon Nayrac, Laurent Alric, M Mavigner, A L Iscache

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, 2019, 220 (5), pp.830-840. ⟨10.1093/infdis/jiz123⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 220 (5), pp.830-840. ⟨10.1093/infdis/jiz123⟩

The restoration of CD4+ T cells, especially T-helper type 17 (Th17) cells, remains incomplete in the gut mucosa of most human immunodeficiency virus type 1 (HIV-1)–infected individuals despite sustained antiretroviral therapy (ART). Herein, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf1141fb4f0f9aada7cab65629d072a
https://ut3-toulouseinp.hal.science/hal-03355691

Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

Autor: Marianne Burbage, Pablo J. Sáez, Deborah Lefevre, Thomas Hoyler, Amal Zine El Aabidine, Rébecca Panes, Guadalupe Suarez, Christel Goudot, Sebastian Amigorena, Jean-Marie Carpier, Mengliang Ye, Fanny Aprahamian, Claire Hivroz, Florence Cammas, Olivier Joffre, Véronique Adoue, Elina Zueva, Jean-Christophe Andrau, Angelique Bellemare-Pelletier, Sylvère Durand, Leonel Joannas, Etienne Gagnon, Maqbool Muhammad Ahmad, Guido Kroemer, Cyril Esnault, Ulf Gehrmann, Sandrine Heurtebise-Chrétien, Nina Burgdorf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩

Significance CD4 T cells are major regulators of immune responses against both self and pathogens. Understanding pathways that govern CD4 T cell differentiation and regulation are thus key for the discovery of new immunoregulatory drug targets. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc87a7d673a9a3997e6fdd23ac6a75
https://hal.archives-ouvertes.fr/hal-02369616/document