Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain

Autor: Patricia Flamant, Isabelle Mouyna, Samantha Gozel, Alix T. Coste, Dominique Sanglard, Frédéric Lamoth, Josie E. Parker, Daniel Bachmann, Marion Aruanno

Publikováno v: Medical Mycology
Medical Mycology, 2021, 59 (8), pp.763-772. ⟨10.1093/mmy/myaa118⟩

Aspergillus fumigatus is the main cause of invasive aspergillosis, for which azole drugs are the first-line therapy. Emergence of pan-azole resistance among A. fumigatus is concerning and has been mainly attributed to mutations in the target gene (cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb3b6e737bb07382af642533e3500dd
https://doi.org/10.1093/mmy/myaa118

A Tunisian family with a novel mutation in the gene CYP 4F22 for lamellar ichthyosis and co‐occurrence of hearing loss in a child due to mutation in the SLC 26A4 gene

Autor: Marwa, Sayeb, Zied, Riahi, Nadia, Laroussi, Crystel, Bonnet, Lilia, Romdhane, Rahma, Mkaouar, Anissa, Zaouak, Jihene, Marrakchi, Ghaith, Abdessalem, Olfa, Messaoud, Oussema, Bouchniba, Nacer, Ghilane, Mourad, Mokni, Ghazi, Besbes, Houda, Yacoub-Youssef, Christine, Petit, Sonia, Abdelhak

Publikováno v: International Journal of Dermatology
International Journal of Dermatology, Wiley-Blackwell, 2019, 58 (12), pp.1439-1443. ⟨10.1111/ijd.14452⟩
International Journal of Dermatology, 2019, 58 (12), pp.1439-1443. ⟨10.1111/ijd.14452⟩

International audience; Background: Co-occurrence of two genetic diseases is challenging for accurate diagnosis and genetic counseling. The recent availability of whole exome sequencing (WES) has dramatically improved the molecular diagnosis of rare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3125ce1e9d247b7e4b0c8558244835e3
https://hal-pasteur.archives-ouvertes.fr/pasteur-03219630

Redirecting P450 EryK Specificity by Rational Site-Directed Mutagenesis

Autor: Beatrice Vallone, Linda Celeste Montemiglio, Chiara Ardiccioni, G. Avella, Alberto Macone, Carmelinda Savino

Publikováno v: Biochemistry (Easton) 52 (2013): 3678–3687. doi:10.1021/bi400223j
info:cnr-pdr/source/autori:Montemiglio, LC [ 1,2 ] ; Macone, A [ 1,2 ] ; Ardiccioni, C [ 3,4 ] ; Avella, G [ 1,2 ] ; Vallone, B [ 1,2 ] ; Savino, C [ 1,2]/titolo:Redirecting P450 EryK specificity by rational site-directed mutagenesis./doi:10.1021%2Fbi400223j/rivista:Biochemistry (Easton)/anno:2013/pagina_da:3678/pagina_a:3687/intervallo_pagine:3678–3687/volume:52
Biochemistry
Biochemistry, American Chemical Society, 2013, 52 (21), pp.3678-87. ⟨10.1021/bi400223j⟩

The C-12 hydroxylase EryK is a bacterial cytochrome P450, active during one of the final tailoring steps of erythromycin A (ErA) biosynthesis. Its tight substrate specificity, restricted to the metabolic intermediate ErD, leads to the accumulation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3864dcc64fe3be942f913c9f61962bb0
https://doi.org/10.1021/bi400223j

Combinations of Cytochrome P450 Gene Polymorphisms Enhancing the Risk for Sporadic Colorectal Cancer Related to Red Meat Consumption

Autor: Sébastien Küry, Louis-Dominique Chupin, Roger Faroux, Stéphane Bézieau, Bernard Lafraise, Sébastien Robiou-du-Pont, Jérémie Bourdon, Bruno Buecher, Tanguy Le Neel, Claire Le Houérou, Jean Ollivry, Véronique Sébille, Catherine Scoul, Hélène Colman

Publikováno v: Cancer Epidemiology, Biomarkers and Prevention
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2007, 16 (7), pp.1460-7. ⟨10.1158/1055-9965.EPI-07-0236⟩

Susceptibility to sporadic colorectal cancers (CRC) is generally thought to be the sum of complex interactions between environmental and genetic factors, all of which contribute independently, producing only a modest effect on the whole phenomenon. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bc16b9e1ee1311366e611608497cca
https://doi.org/10.1158/1055-9965.epi-07-0236

Immunohistochemical detection of the human cytochrome P4507B1: production of a monoclonal antibody after cDNA immunization

Autor: Farida Nato, Sonia Chalbot, Catherine Trap, Sae-Bom Kim, Pierre Lafaye, Robert Morfin

Publikováno v: Journal of Neuroimmunology
Journal of Neuroimmunology, 2005, 159 (1-2), pp.41-47. ⟨10.1016/j.jneuroim.2004.09.019⟩

International audience; The cytochrome P4507B1 (P4507B1) is responsible for the 7alpha-hydroxylation of dehydroepiandrosterone (DHEA) and other 3beta-hydroxysteroids in the brain and other organs. The cDNA of human P4507B1 was used for DNA immunizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8850b9bb5fad423a4c8643fa44b613c
https://doi.org/10.1016/j.jneuroim.2004.09.019