Tissue kallikrein is required for the cardioprotective effect of Cyclosporin A in myocardial ischemia in the mouse

Autor: C. Richer, M.-P. Vincent, G. Youcef, François Alhenc-Gelas, Anne Pizard, Elise Belaidi, M. Clemessy, L. Fazal, Ludovic Waeckel, G. Zadigue, Michel Ovize

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2015, 94 (1), pp.22-29. ⟨10.1016/j.bcp.2015.01.007⟩
Biochemical Pharmacology, 2015, 94 (1), pp.22-29. ⟨10.1016/j.bcp.2015.01.007⟩

International audience; Clinical and experimental studies suggest that pharmacological postconditioning with Cyclosporin A (CsA) reduces infarct size in cardiac ischemia and reperfusion. CsA interacts with Cyclophilin D (CypD) preventing opening of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db81b18cd655788987a4450d868fcf43
https://doi.org/10.1016/j.bcp.2015.01.007

Quantitative proteomic analysis of cyclosporine-induced toxicity in a human kidney cell line and comparison with tacrolimus

Autor: Elodie Mestre, Pierre Marquet, François-Ludovic Sauvage, Fabien Lamoureux, Marie Essig, Louis Noël Gastinel

Publikováno v: Journal of Proteomics
Journal of Proteomics, Elsevier, 2011, 75 (2), pp.677-94. ⟨10.1016/j.jprot.2011.09.005⟩

International audience; The calcineurin-inhibitors (CNIs) cyclosporine (CsA) and tacrolimus (TAC) remain the pillars of modern immunosuppression regimens used in solid organ transplantation. Nephrotoxicity is an adverse effect that limits their succe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583bed05aead43909de19afc5364c431
https://www.hal.inserm.fr/inserm-00925562

Cell death by necrosis: towards a molecular definition

Autor: Guido Kroemer, Pierre Golstein

Publikováno v: Trends in Biochemical Sciences
Trends in Biochemical Sciences, Elsevier, 2007, 32 (1), pp.37-43. ⟨10.1016/j.tibs.2006.11.001⟩
Trends in Biochemical Sciences, 2007, 32 (1), pp.37-43. ⟨10.1016/j.tibs.2006.11.001⟩

Necrosis has been defined as a type of cell death that lacks the features of apoptosis and autophagy, and is usually considered to be uncontrolled. Recent research suggests, however, that its occurrence and course might be tightly regulated. After si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49efdac8de413adfcd834e59c1e5a82c
https://hal.archives-ouvertes.fr/hal-00165336

Octasaccharide is the minimal length unit required for efficient binding of cyclophilin B to heparin and cell surface heparan sulphate

Autor: Fabrice Allain, Rachel Pakula, Agnès Denys, Joël Mazurier, Christophe Vanpouille, Mathieu Carpentier

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2004, 382 (Pt 2), pp.733-40. ⟨10.1042/BJ20031453⟩
Biochemical Journal, 2004, 382 (Pt 2), pp.733-40. ⟨10.1042/BJ20031453⟩

Cyclophilin B (CyPB) is a heparin-binding protein first identified as a receptor for cyclosporin A. In previous studies, we reported that CyPB triggers chemotaxis and integrin-mediated adhesion of T-lymphocytes by way of interaction with two types of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a50615138a38789a96aebdde4c45364
https://hal.archives-ouvertes.fr/hal-00149442

Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix

Autor: Marie-Christine Slomianny, Fabrice Allain, Sandrine Durieux, Geneviève Spik, Mathieu Carpentier, Christophe Vanpouille

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 (5), pp.2714-9. ⟨10.1073/pnas.052284899⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2002, 99 (5), pp.2714-9. ⟨10.1073/pnas.052284899⟩

Cyclophilins A and B (CyPA and CyPB) are cyclosporin A-binding proteins that are involved in inflammatory events. We have reported that CyPB interacts with two types of cell-surface-binding sites. The first site corresponds to a functional receptor a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f308b6227456c8d9cfe389b032cd8d
https://hal.science/hal-00167221