Long-Term Control of Hypercortisolism by Vandetanib in a Case of Medullary Thyroid Carcinoma with a Somatic RET Mutation

Autor: Marie Bienvenu-Perrard, Anne-Cécile Paepegaey, Najiba Lahlou, Lionel Groussin, Estelle Louiset, Léopoldine Bricaire, Béatrix Cochand-Priollet, Marco Alifano, Nelly Burnichon, Pierre-Olivier Sarfati

Publikováno v: Thyroid
Thyroid, Mary Ann Liebert, 2017, 27 (4), pp.587-590. ⟨10.1089/thy.2016.0334⟩

Medullary thyroid carcinomas (MTCs) complicated by ectopic Cushing's syndrome (CS) have a poor prognosis, partially due to the difficulty in controlling hypercortisolism by adrenal blocking drugs. Recent reports (including the initial follow-up of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781afc5b5aeaf3e785d3f2927c05161e
https://hal-normandie-univ.archives-ouvertes.fr/hal-01945860

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

Autor: Ulrike Zabel, Thomas Wieland, Martin J. Lohse, Fabio R. Faucz, Annalisa Vetro, Andrea Osswald, Guillaume Assié, Cristina L. Ronchi, Thomas Schwarzmayr, Susanne Diener, Caroline Kisker, Bruno Allolio, Tim M. Strom, Silviu Sbiera, Olivia Barreau, Martin Reincke, Delphine Vezzosi, Felix Beuschlein, Jérôme Bertherat, Orsetta Zuffardi, Antonella Forlino, Thomas Meitinger, Martin Fassnacht, Katrin Schaak, Eva Szarek, Constantine A. Stratakis, Anett Schmittfull, Paraskevi Salpea, Davide Calebiro, Marthe Rizk-Rabin

Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-1028. ⟨10.1056/NEJMoa1310359⟩
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-28. 〈10.1056/NEJMoa1310359〉
New England Journal of Medicine, Massachusetts Medical Society, 2014, 370 (11), pp.1019-28. ⟨10.1056/NEJMoa1310359⟩
New England Journal of Medicine, 2014, 370 (11), pp.1019-28. ⟨10.1056/NEJMoa1310359⟩

International audience; BACKGROUND: Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood. METHODS: We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd92b522a983c9b7b564fa4686b280
https://hal.archives-ouvertes.fr/hal-02376099

[Cushing syndrome and pregnancy: a propos of a malignant adrenocortical carcinoma]

Autor: Homer, Lionel, Viatge, M., Gayet, F.-X., Laurent, Y., Kerlan, Véronique

Publikováno v: Gynécologie Obstétrique & Fertilité
Gynécologie Obstétrique & Fertilité, Elsevier Masson, 2012, 40 (3), pp.e1-4. ⟨10.1016/j.gyobfe.2011.07.053⟩

International audience; Cushing's syndrome is a rare condition in the general population (1/1000000) and is even less common during pregnancy. We report the case of a patient cared at 27 weeks of gestation (wg) for hypertension and electolyte disturb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::335b723d64308f76a8974300ec7e3ed4
https://pubmed.ncbi.nlm.nih.gov/22342109

Medical treatment of Cushing's syndrome: glucocorticoid receptor antagonists and mifepristone

Autor: Frederic Castinetti, Bernard Conte-Devolx, Thierry Brue

Publikováno v: Neuroendocrinology
Neuroendocrinology, Karger, 2010, 92 Suppl 1, pp.125-30. ⟨10.1159/000314224⟩
Neuroendocrinology, 2010, 92 Suppl 1, pp.125-30. ⟨10.1159/000314224⟩

International audience; Mifepristone is the first and only available glucocorticoid receptor antagonist. It was initially mainly considered as a so-called 'contragestive' pill due to its antiprogestin activity. In this review, we summarize the result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f5c35061f3112c760b43028e262916
https://pubmed.ncbi.nlm.nih.gov/20829633

Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis

Autor: Tânia Longo Mazzuco, Olivier Chabre, Michaël Thomas, Jean-Jacques Feige

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2007, 265-266, pp.23-8. ⟨10.1016/j.mce.2006.12.034⟩
Molecular and Cellular Endocrinology, 2007, 265-266, pp.23-8. ⟨10.1016/j.mce.2006.12.034⟩
Molecular and Cellular Endocrinology, Elsevier, 2009, 265-266, pp.23. ⟨10.1016/j.mce.2006.12.034⟩

International audience; Aberrant expression of G protein-coupled receptors (GPCR) in the adrenal cortex is observed in some cases of ACTH-independent macronodular adrenal hyperplasias and adenomas associated with Cushing syndrome (CS). Although there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb95a9be797335e708c47bae23373e6
https://www.hal.inserm.fr/inserm-00376122