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Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: Particular sensitivity of the heart

Autor: Max Dolder, Oliver Speer, Malgorzata Tokarska-Schlattner, Uwe Schlattner, Theo Wallimann, Isabelle Gerber

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2007, 1767 (11), pp.1276-84. ⟨10.1016/j.bbabio.2007.08.006⟩

International audience; Doxorubicin (DXR) belongs to the most efficient anticancer drugs. However, its use is limited by a risk of cardiotoxicity, which is not completely understood. Recently, we have shown that DXR impairs essential properties of pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff047199e4b06fa4a0386fc3825d04b9
https://doi.org/10.1016/j.bbabio.2007.08.006

A deconvolution method for the separation of specific versus nonspecific interactions in noncovalent protein-ligand complexes analyzed by ESI-FT-ICR mass spectrometry

Autor: Guillaume van der Rest, Thorsten Daubenfeld, Anne-Pascale Bouin

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, 2006, 17 (9), pp.1239-48. ⟨10.1016/j.jasms.2006.05.005⟩
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2006, 17 (9), pp.1239-48. ⟨10.1016/j.jasms.2006.05.005⟩

A method to separate specific and nonspecific noncovalent interactions observed in ESI mass spectra between a protein and its ligands is presented. Assuming noncooperative binding, the specific ligand binding is modeled as a statistical distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200dac4ad6f8c056b6f5210a75c6b2c1
https://doi.org/10.1016/j.jasms.2006.05.005

Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery

Autor: Frank N. Gellerich, Enn Seppet, Mati Ress, Ehte Orlova, Stephan Zierz, Nadezhda Peet, Kalju Paju, Valdur A. Saks, Evelin Seppet, Margus Eimre, Sirje Kõvask, Andres Piirsoo

Publikováno v: Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry, Springer Verlag, 2005, 270 (1-2), pp.49-61

International audience; The parameters of oxidative phosphorylation and its interaction with creatine kinase (CK)- and adenylate kinase (AK)-phosphotransfer networks in situ were studied in skinned atrial fibers from 59 patients undergoing coronary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3c35eb0b84178570927647e76f6759
https://doi.org/10.1007/s11010-005-3780-y

Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

Autor: Franz Staeb, Horst Wenck, Melanie Schmidt, Vivienne Welge, Holger Lenz, Uwe Schlattner, Thomas Kueper, Hans-Peter Elsässer, Theo Wallimann, Klaus-Peter Wittern, Thomas Blatt

Publikováno v: Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry, Springer Verlag, 2007, 306 (1-2), pp.153-62. ⟨10.1007/s11010-007-9565-8⟩

International audience; The creatine kinase (CK) system is essential for cellular energetics in tissues or cells with high and fluctuating energy requirements. Creatine itself is known to protect cells from stress-induced injury. By using an siRNA ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83505a98fe44f1bced82746486b3f297
https://www.hal.inserm.fr/inserm-00390914