The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Autor: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani

Publikováno v: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩

International audience; The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as cholesterol in animals. We found that it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cab00f461442b882b9cc5b78e1a41
https://doi.org/10.1016/j.molbiopara.2018.10.001

Self-association of MreC as a regulatory signal in bacterial cell wall elongation

Autor: Carlos Contreras-Martel, Leandro F. Estrozi, Daniel M. Trindade, Mayara M. Miyachiro, Fernanda Rodrigues-Costa, Ina Attrée, Guy Schoehn, Caíque C. Malospirito, Alexandre Martins, Viviana Job, Andréa Dessen, Lionel Imbert, Manon Janet-Maitre

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22957-9⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2987. ⟨10.1038/s41467-021-22957-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, 2021, 12 (1), pp.2987. ⟨10.1038/s41467-021-22957-9⟩

The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cfc0966af3321d6631a2a3d7bddc79
http://europepmc.org/articles/PMC8137920

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae)

Autor: Milena Mechkarska, J. Michael Conlon, Laurent Coquet, Thierry Jouenne, Jérôme Leprince, Renoir J. Auguste, Maria Luisa Mangoni

Publikováno v: Comparative Biochemistry and Physiology-Part D: Genomics and Proteomics
Comparative Biochemistry and Physiology-Part D: Genomics and Proteomics, Elsevier, 2018, 28, pp.72-79. ⟨10.1016/j.cbd.2018.06.006⟩

International audience; Peptidomic analysis (reversed-phase HPLC combined with MALDI-TOF mass spectrometry and automated Edman degradation) of norepinephrine-stimulated skin secretions from the Trinidadian leaf frog Phyllomedusa trinitatis Mertens 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d8ac132402e20bcd83e05d84ec442a
https://hal-normandie-univ.archives-ouvertes.fr/hal-01973119

Micro-time scale genome evolution among natural populations of Streptomyces

Autor: TOUSSAINT, Maxime, Tidjani, Abdoul-Razak, Lorenzi, Jean-Noël, Hotel, Laurence, Lespinet, Olivier, Cyril, Bontemps, Leblond, Pierre

Publikováno v: International Symposium of the Biology of Actinomycetes
International Symposium of the Biology of Actinomycetes, May 2017, Jeju, South Korea

International audience; Genome dynamics is crucial for bacterial genome evolution and adaptation. Here we reveal the unexpectedly fast genome diversification occurring within a highly genetically cohesive population of soil bacteria Streptomyces. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fef9afad07ce96a8dde26bf1ee643343
https://hal.univ-lorraine.fr/hal-01625360

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

Autor: Charlotte Passemar, Alexandre Pawlik, Wladimir Malaga, Flavie Moreau, Mamadou Daffé, Carlos Martin, Roland Brosch, Christophe Guilhot, Catherine Astarie-Dequeker, Françoise Laval, Jesús Gonzalo-Asensio

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (31), pp.11491-11496. ⟨10.1073/pnas.1406693111⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (31), pp.11491-11496. ⟨10.1073/pnas.1406693111⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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International audience; Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and cause disease, long-term epidemiological data indicate that humans represent a spill-over host in which infection with M. bovis is not sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d71c0a455726970b4a1c9fe0ec44b4
https://doi.org/10.1073/pnas.1406693111