Zobrazeno 1 - 10 of 13 pro vyhledávání: '"MESH: Clinical Trials, Phase I as Topic"'
1
Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome
Autor: Magnani, A., Semeraro, M., Adam, F., Booth, C., Dupré, L., Morris, E. C., Gabrion, A., Roudaut, C., Borgel, D., Toubert, A., Clave, E., Abdo, C., Gorochov, G., Petermann, R., Guiot, M., Miyara, M., Moshous, D., Magrin, E., Denis, A., Suarez, F., Lagresle, C., Roche, A. M., Everett, J., Trinquand, A., Guisset, M., Bayford, J. Xu, Hacein-Bey-Abina, S., Kauskot, A., Elfeky, R., Rivat, C., Abbas, S., Gaspar, H. B., Macintyre, E., Picard, C., Bushman, F. D., Galy, A., Fischer, A., Six, E., Thrasher, A. J., Cavazzana, M.
Publikováno v: NATURE MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Universidad de las Islas Baleares
Nature Medicine
Nature Medicine, 2022, 28 (1), pp.71-80. ⟨10.1038/s41591-021-01641-x⟩
Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-matched donor may benefit from gene therapy through the provision of gene-corrected, autologous hematopoietic stem/progenitor cells. Here, we present comprehensive, long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3f98b89d4b68a773ab2a2e9643726a
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21058
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2
Concurrent gemcitabine and radiotherapy for the treatment of muscle-invasive bladder cancer: A pooled individual data analysis of eight phase I-II trials
Autor: Giovanni L. Pappagallo, David Azria, Orazio Caffo, Maria De Santis, Enzo Galligioni, Ananya Choudhury, Borut Kragelj, Daniel A. Hamstra, Gianni Fellin, C. Thompson
Publikováno v: Radiotherapy and Oncology
Radiotherapy and Oncology, Elsevier, 2016, 121 (2), pp.193-198. ⟨10.1016/j.radonc.2016.09.006⟩
International audience; PURPOSE:Although radical cystectomy is still considered the standard of care for most localized muscle-invasive bladder cancer (MIBC) patients, bladder-sparing strategies with chemoradiotherapy have demonstrated comparable loc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65102bc53c9e5b0ba01a7a1185062d18
https://pubmed.ncbi.nlm.nih.gov/27720221
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3
Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer
Autor: Xavier Pivot, C Villanueva, W Yin, Mark D. Pegram, Fredrik Erlandsson, Nuhad K. Ibrahim, D Mir, B Royer
Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2010, 102 (5), pp.827-32. ⟨10.1038/sj.bjc.6605560⟩
International audience; BACKGROUND: HuHMFG1 (AS1402) is a humanised monoclonal antibody that has undergone a phase I trial in metastatic breast cancer. The aim of this study was to characterise the pharmacokinetics (PKs) of HuHMFG1 using a population
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7265fd29b2590015f6d2f3c96172c4
http://europepmc.org/articles/PMC2833251
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4
Complex parent-metabolite PK model
Autor: Julie Bertrand, Céline M. Laffont, France Mentré, Marylore Chenel, Emmanuelle Comets
Publikováno v: Aaps Journal-Electronic Edition
Aaps Journal-Electronic Edition-, 2011, 13 (3), pp.390-404. ⟨10.1208/s12248-011-9282-9⟩
International audience; This study aimed to develop a joint population pharmacokinetic model for an antipsychotic agent in development (S33138) and its active metabolite (S35424) produced by reversible metabolism. Because such a model leads to identi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7e9f254d1ff6f7ae2d5576cb0ba269
https://www.hal.inserm.fr/inserm-00606915
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5
Development of a complex parent-metabolite joint population pharmacokinetic model
Autor: Bertrand, Julie, Laffont, Céline M., Mentré, France, Chenel, Marylore, Comets, Emmanuelle
Publikováno v: Aaps Journal-Electronic Edition
Aaps Journal-Electronic Edition-, 2011, 13 (3), pp.390-404. ⟨10.1208/s12248-011-9282-9⟩
International audience; This study aimed to develop a joint population pharmacokinetic model for an antipsychotic agent in development (S33138) and its active metabolite (S35424) produced by reversible metabolism. Because such a model leads to identi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::c28298903c72f05e7b93c14b9fa63a56
https://www.hal.inserm.fr/inserm-00606915
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6
Development of a complex parent-metabolite joint population pharmacokinetic model
Autor: Bertrand, Julie, Laffont, Céline M., Mentré, France, Chenel, Marylore, Comets, Emmanuelle
Publikováno v: Aaps Journal-Electronic Edition
Aaps Journal-Electronic Edition-, 2011, 13 (3), pp.390-404. ⟨10.1208/s12248-011-9282-9⟩
International audience; This study aimed to develop a joint population pharmacokinetic model for an antipsychotic agent in development (S33138) and its active metabolite (S35424) produced by reversible metabolism. Because such a model leads to identi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c28298903c72f05e7b93c14b9fa63a56
https://www.hal.inserm.fr/inserm-00606915
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7
A decade of tyrosine kinase inhibitor therapy: Historical and current perspectives on targeted therapy for GIST
Autor: Jean-Yves Blay
Publikováno v: Cancer Treatment Reviews
Cancer Treatment Reviews, WB Saunders, 2011, 37 (5), pp.373-84. ⟨10.1016/j.ctrv.2010.11.003⟩
International audience; The introduction of molecularly targeted therapies has ushered in a considerable transformation in the management of gastrointestinal stromal tumors (GIST) that currently defines the paradigm of targeted therapy for solid tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b07a98ca2cd37c13699abd968a307e6
https://hal.archives-ouvertes.fr/hal-00778570
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8
Overview of Cellular Immunotherapy for Patients with Glioblastoma
Autor: Brigitte Collet, Tony Avril, Jean Mosser, Véronique Quillien, Elodie Vauleon
Publikováno v: Clinical and Developmental Immunology, Vol 2010 (2010)
Clinical and Developmental Immunology
Clinical and Developmental Immunology, Hindawi Publishing Corporation, 2010, 2010, pp.689171. ⟨10.1155/2010/689171⟩
Clinical and Developmental Immunology, 2010, 2010, pp.689171. ⟨10.1155/2010/689171⟩
International audience; High grade gliomas (HGG) including glioblastomas (GBM) are the most common and devastating primary brain tumours. Despite important progresses in GBM treatment that currently includes surgery combined to radio- and chemotherap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8398d33035baedf4d0a3bd2e61f36aa0
https://doaj.org/article/0e255c1042be45988da8c0e70f47df2d
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9
Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results
Autor: Marylore Chenel, François Bouzom, Fanny Cazade, Kayode Ogungbenro, Leon Aarons, France Mentré
Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics
Journal of Pharmacokinetics and Pharmacodynamics, Springer Verlag, 2008, 35 (6), pp.661-81. ⟨10.1007/s10928-008-9105-5⟩
International audience; PURPOSE: To compare results of population PK analyses obtained with a full empirical design (FD) and an optimal sparse design (MD) in a Drug-Drug Interaction (DDI) study aiming to evaluate the potential CYP3A4 inhibitory effec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d20fc743d218cb5f14942e7703ab2f
https://www.hal.inserm.fr/inserm-00383725/file/P2_DDI_OptDesign_reviewed.pdf
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10
Ixabepilone, a novel epothilone analog in the treatment of breast cancer
Autor: Xavier Pivot, Martin Demarchi, Ulrich Stein, Loic Chaigneau, C. Villanueva, Tristan Maurina, Thierry Nguyen, Christophe Borg
Publikováno v: Expert Opinion on Investigational Drugs
Expert Opinion on Investigational Drugs, Taylor & Francis, 2008, 17 (4), pp.593-9. ⟨10.1517/13543784.17.4.593⟩
International audience; BACKGROUND: Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra) is an epothilone analog that optimizes the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab27e940021653bdd59dd4229537e7ac
https://www.hal.inserm.fr/inserm-00483392
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