Výsledky vyhledávání - "MESH: Citric Acid Cycle"

SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes

Autor: Christian Njoo, Stefan G. Lechner, Mirko Moroni, Francisco J. Taberner, Faramarz Faghihi, Daniel Rangel Rojas, Thomas Fleming, Alexandra Andrieux, Nitin Agarwal, Gary R. Lewin, Pooja Gupta, Kiran Kumar Bali, Anne Dejean, Esther Herpel, Rohini Kuner, Peter P. Nawroth, Damir Omberbasic

Publikováno v: Neuron
Neuron, 2020, 107 (6), pp.1141-1159.e7. ⟨10.1016/j.neuron.2020.06.037⟩
Neuron, Elsevier, 2020, 107 (6), pp.1141-1159.e7. ⟨10.1016/j.neuron.2020.06.037⟩

International audience; Diabetic peripheral neuropathy (DPN) is a highly frequent and debilitating clinical complication of diabetes that lacks therapies. Cellular oxidative stress regulates post-translational modifications, including SUMOylation. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5d4cb795a7249a1ea608f05bd207d5
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234828

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GarA is an essential regulator of metabolism in Mycobacterium tuberculosis

Autor: Ventura, Marcello, Rieck, Barbara, Boldrin, Francesca, Degiacomi, Giulia, Bellinzoni, Marco, Barilone, Nathalie, Alzaidi, Faisal, Alzari, Pedro, Manganelli, Riccardo, O'Hare, Helen

Publikováno v: Molecular Microbiology
Molecular Microbiology, 2013, 90 (2), pp.356-66. ⟨10.1111/mmi.12368⟩
Molecular Microbiology; Vol
Molecular Microbiology, Wiley, 2013, 90 (2), pp.356-66. ⟨10.1111/mmi.12368⟩

International audience; Alpha-ketoglutarate is a key metabolic intermediate at the crossroads of carbon and nitrogen metabolism, whose fate is tightly regulated. In mycobacteria the protein GarA regulates the tricarboxylic acid cycle and glutamate sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::54708f0de488388871abe16b52ca2124
https://hal-pasteur.archives-ouvertes.fr/pasteur-03096131

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Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes

Autor: Rita Guzun, Michael Zaugg, Malgorzata Tokarska-Schlattner, Eliana Lucchinetti, Séverine Gratia, Uwe Schlattner, Laurence Kay, Valdur Saks

Publikováno v: AJP-Regulatory, Integrative and Comparative Physiology
AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2010, 298 (4), pp.R1075-88. ⟨10.1152/ajpregu.00360.2009⟩

International audience; Doxorubicin (DXR) belongs to the most efficient anticancer drugs. However, its clinical application is limited by the risk of severe cardiac-specific toxicity, for which an efficient treatment is missing. Underlying molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c497096e2b2ba2f3647041799df0d2
https://pubmed.ncbi.nlm.nih.gov/20053966

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Rapid determination of tricarboxylic acid cycle enzyme activities in biological samples

Autor: Pierre Rustin, Sergio Goncalves, Emmanuel P. Dassa, Jean-Jacques Brière, Vincent Paupe, Paule Bénit, Judith Favier, Anne-Paule Gimenez-Roqueplo

Publikováno v: BMC Biochemistry
BMC Biochemistry, BioMed Central, 2010, 11 (1), pp.5. ⟨10.1186/1471-2091-11-5⟩
BMC Biochemistry, Vol 11, Iss 1, p 5 (2010)
BMC Biochemistry, BioMed Central, 2010, 11 (1), pp.5. 〈10.1186/1471-2091-11-5〉

Background In the last ten years, deficiencies in tricarboxylic acid cycle (TCAC) enzymes have been shown to cause a wide spectrum of human diseases, including malignancies and neurological and cardiac diseases. A prerequisite to the identification o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39982e1ea883fbd502e9c0794b15c851
https://www.hal.inserm.fr/inserm-00668472/document

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In folio respiratory fluxomics revealed by 13C isotopic labeling and H/D isotope effects highlight the noncyclic nature of the tricarboxylic acid 'cycle' in illuminated leaves

Autor: Paul P. G. Gauthier, Gabriel Cornic, Caroline Mauve, Aline Mahé, Elizabeth Gout, Richard Bligny, Guillaume Tcherkez, Michael Hodges

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2009, 151 (2), pp.620-30. ⟨10.1104/pp.109.142976⟩
Plant Physiology, 2009, 151 (2), pp.620-30. ⟨10.1104/pp.109.142976⟩

While the possible importance of the tricarboxylic acid (TCA) cycle reactions for leaf photosynthesis operation has been recognized, many uncertainties remain on whether TCA cycle biochemistry is similar in the light compared with the dark. It is wid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10618105639c6aff2e00df33b2f317ba
https://hal.archives-ouvertes.fr/hal-00448349

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Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production

Autor: Margit Heiske, Kevin Thurley, Christine Nazaret, Jean-Pierre Mazat

Publikováno v: Journal of Theoretical Biology
Journal of Theoretical Biology, Elsevier, 2009, 258 (3), pp.455-64. ⟨10.1016/j.jtbi.2008.09.037⟩
Journal of Theoretical Biology, Elsevier, 2009, 258, pp.455-464

International audience; Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c0753058bbe2eac172ff64a0fa224
https://hal.archives-ouvertes.fr/hal-00462362

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Effects of resveratrol on the rat brain respiratory chain

Autor: R, Zini, C, Morin, A, Bertelli, A A, Bertelli, J P, Tillement

Publikováno v: Drugs Under Experimental and Clinical Research
Drugs Under Experimental and Clinical Research, Bioscience Ediprint; 1999, 1999, 25 (2-3), pp.87-97
HAL

International audience; The aim of this work was to investigate the possible effects of resveratrol on the mitochondrial respiratory chain in rat brains. Isolation of mitochondria was performed at 4 degrees C using differential centrifugation. Mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::24742a86517d7dbfda57e2c4d76dc475
https://hal-enpc.archives-ouvertes.fr/hal-02268278

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