SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

Autor: Robinot, Rémy, Hubert, Mathieu, de Melo, Guilherme Dias, Lazarini, Françoise, Bruel, Timothée, Smith, Nikaïa, Levallois, Sylvain, Larrous, Florence, Fernandes, Julien, Gellenoncourt, Stacy, Rigaud, Stéphane, Gorgette, Olivier, Thouvenot, Catherine, Trébeau, Céline, Mallet, Adeline, Duménil, Guillaume, Gobaa, Samy, Etournay, Raphaël, Lledo, Pierre-Marie, Lecuit, Marc, Bourhy, Hervé, Duffy, Darragh, Michel, Vincent, Schwartz, Olivier, Chakrabarti, Lisa

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4354. ⟨10.1038/s41467-021-24521-x⟩
Nature Communications, 2021, 12 (1), pp.4354. ⟨10.1038/s41467-021-24521-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1b12422ca9e4b330a8b8cbf638580505
https://hal-pasteur.archives-ouvertes.fr/pasteur-03319522/document

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs

Autor: Isabel Tapia-Páez, Eero Castrén, Andrea Bieder, Kristiina Tammimies, Debora Sugiaman-Trapman, Gilbert Lauter, Peter Swoboda, Rachel Torchet, Marie-Estelle Hokkanen, Juha Kere, Jan Burghoorn

Publikováno v: The FASEB Journal
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2016, 30 (10), pp.3578-3587. ⟨10.1096/fj.201500124RR⟩

International audience; DYX1C1, DCDC2, and KIAA0319 are three of the most replicated dyslexia candidate genes (DCGs). Recently, these DCGs were implicated in functions at the cilium. Here, we investigate the regulation of these DCGs by Regulatory Fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d8c20a6a22d896550c5b75a303e6a6
http://europepmc.org/articles/PMC5024701

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

Autor: Stefan Lamla, Philippe Bastin, Erich A. Nigg, Thierry Blisnick, Sagar Bhogaraju, Naoko Mizuno, Cécile Fort, Kristina Weber, Lukas Cajanek, Michael Taschner, Esben Lorentzen

Publikováno v: SCIENCE
Science
Science, American Association for the Advancement of Science, 2013, 341 (6149), pp.1009-1012. ⟨10.1126/science.1240985⟩
Aarhus University
Science, 2013, 341 (6149), pp.1009-1012. ⟨10.1126/science.1240985⟩
Bhogaraju, S, Cajanek, L, Fort, C, Blisnick, T, Weber, K, Taschner, M, Mizuno, N, Lamla, S, Bastin, P, Nigg, E A & Lorentzen, E 2013, ' Molecular basis of tubulin transport within the cilium by IFT74 and IFT81 ', Science, bind 341, nr. 6149, s. 1009-1012 .

Cilium Conundrum The cilium has emerged as the antenna of eukaryotic cells, having numerous functions in sensory reception and developmental signaling. Several disorders, such as polycystic kidney disease, are the result of compromised cilia structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d75efcc751fded9647aef1882c78c9
http://www.sciencemag.org/content/341/6149/1009.long

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella

Autor: Pierre-Simon Jouk, Nicolas Thierry-Mieg, Pierre F. Ray, Karine Pernet-Gallay, Thomas Karaouzène, Denise Escalier, Charles Coutton, Christophe Arnoult, Virginie Pierre, Marie Bidart, Sylviane Hennebicq, Mariem Ben Khelifa, Raoudha Zouari, Didier Grunwald, John Rendu, Aminata Touré, Julie Delaroche, Sandra Yassine

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2014, 94 (1), pp.95-104. 〈10.1016/j.ajhg.2013.11.017〉
American Journal of Human Genetics, 2014, 94 (1), pp.95-104. ⟨10.1016/j.ajhg.2013.11.017⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2014, 94 (1), pp.95-104. ⟨10.1016/j.ajhg.2013.11.017⟩

International audience; Ten to fifteen percent of couples are confronted with infertility and a male factor is involved in approximately half the cases. A genetic etiology is likely in most cases yet only few genes have been formally correlated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da5db20237ec21a70bf706cc0e13dc3
https://hal-riip.archives-ouvertes.fr/pasteur-01061012/file/1-s2.0-S0002929713005326-main.pdf

Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape

Autor: Christine Petit, Dominique Weil, Michel Leibovici, Vincent Michel, Isabelle Foucher, Nadège Cayet, Raphaël Etournay, Jean-Pierre Hardelin, Jacques Boutet de Monvel, Léa Lepelletier

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2010, 137 (8), pp.1373-83. ⟨10.1242/dev.045138⟩
Development (Cambridge, England), Company of Biologists, 2010, 137 (8), pp.1373-83. ⟨10.1242/dev.045138⟩

International audience; Epithelial cells acquire diverse shapes relating to their different functions. This is particularly relevant for the cochlear outer hair cells (OHCs), whose apical and basolateral shapes accommodate the functioning of these ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8846a56e4001addb44ed23b688f9dc3e
https://doi.org/10.1242/dev.045138