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pro vyhledávání: '"MESH: Chromosome Fragile Sites / physiology"'
Autor:
Marion Blin, Caroline Brossas, Gaël A. Millot, Mélanie Schmidt, Viola Nähse, Marie-Noëlle Prioleau, Michelle Debatisse, Benoît Le Tallec
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
International audience; Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late in S phase, are cell-type specific and nest in large genes. The rel