Mechanisms Regulating Tumor Angiogenesis by 12-Lipoxygenase in Prostate Cancer Cells

Autor: Kenneth V. Honn, Alex Zacharek, Daotai Nie, Julie Milanini, Rongxian Jin, Gilles Pagès, Keqin Tang, Yande Guo, Yan Qiao, YuChyu Chen, Sriram Krishnamoorthy

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. ⟨10.1074/jbc.M601887200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. 〈10.1074/jbc.M601887200〉

International audience; 12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promotes tumorigenesis and metastasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb23aa65f5113defe54dcf457969991
https://doi.org/10.1074/jbc.m601887200

Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors

Autor: Pierre Champelovier, Virginie Pautre, François Berger, Daniel Seigneurin, Michèle El Atifi, Béatrice Rostaing

Publikováno v: Experimental Hematology
Experimental Hematology, Elsevier, 2008, 36 (1), pp.28-36. ⟨10.1016/j.exphem.2007.08.027⟩
Experimental Hematology, 2008, 36 (1), pp.28-36. ⟨10.1016/j.exphem.2007.08.027⟩

International audience; OBJECTIVE: The roles of phosphatidylinositol 3 (PI3K) and mitogen-activated protein kinases (MAPK) have been widely studied in terms of the differentiation process induced by several drugs (phorbol ester, vitamin D-3, retinoic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a95d8598d87e44b53898d8f402014c
https://doi.org/10.1016/j.exphem.2007.08.027

Targeting the PI3K/mTOR pathway in murine endocrine cell lines: in vitro and in vivo effects on tumor cell growth

Autor: Couderc , Christophe, Poncet , Gilles, Villaume , Karine, Blanc , Martine, Gadot , Nicolas, Walter , Thomas, Lepinasse , Florian, Hervieu , Valérie, Cordier-Bussat , Martine, Scoazec , Jean-Yves, Roche , Colette

Publikováno v: American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (1), pp.336-44. 〈10.1016/j.ajpath.2010.11.023〉
American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (1), pp.336-44. ⟨10.1016/j.ajpath.2010.11.023⟩

International audience; The mammalian target of rapamycin (mTOR) inhibitors, such as rapalogues, are a promising new tool for the treatment of metastatic gastroenteropancreatic endocrine tumors. However, their mechanisms of action remain to be establ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::40dfa6c3a63bc2ac5aa4cef05fb4091d
https://hal.archives-ouvertes.fr/hal-00710288

Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QM7 myoblasts

Autor: Mohammed Taouis, Karine Bigot, Sophie Tesseraud

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2003, 540 (1-3), pp.176-180. ⟨10.1016/s0014-5793(03)00260-6⟩
FEBS Letters, Wiley, 2003, 540, pp.176-180

International audience; The regulation of S6K1 by nutritional status and insulin has been recently reported in vivo in chicken muscle despite the relative insulin resistance of this tissue as estimated by phosphatidylinositol 3-kinase (PI3-kinase) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5ec23b99df545c7604c35ee672d3d0
https://pubmed.ncbi.nlm.nih.gov/12681504

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

Autor: Elodie Bruel-Jungerman, Serge Laroche, Franck Dufour, Jennifer M. Horwood, Sabrina Davis, Alexandra Veyrac

Publikováno v: PLoS ONE; Vol 4
PLoS ONE
PLoS ONE, Vol 4, Iss 11, p e7901 (2009)
PLoS ONE, Public Library of Science, 2009, 4 (11), pp.e7901. ⟨10.1371/journal.pone.0007901⟩

Background Physical exercise has been shown to increase adult neurogenesis in the dentate gyrus and enhances synaptic plasticity. The antiapoptotic kinase, Akt has also been shown to be phosphorylated following voluntary exercise; however, it remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11439bbd721a213a57c521b6de7b9863
https://doi.org/10.1371/journal.pone.0007901