Histone variant H2A.Z regulates zygotic genome activation

Autor: Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩

During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7911d2dde2a04081f895092d6c6f58d5
https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9

Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy

Autor: Arnaud Echard, Hugo Wioland, Frédérique Cuvelier, Guillaume Romet-Lemonne, Tamara Advedissian, Jian Bai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proc Natl Acad Sci U S A

International audience; Abscission is the terminal step of cytokinesis leading to the physical separation of the daughter cells. In response to the abnormal presence of lagging chromatin between dividing cells, an evolutionarily conserved abscission/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5139df330b93d415d9a12ca7d187948c
https://doi.org/10.1073/pnas.1911629117

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

Autor: Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩

International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y

Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report

Autor: Fabrice Lopez, Philippe Bulet, Nicolas Thierry-Mieg, Virginie Tassistro, Caroline Cazin, Pierre F. Ray, Karim Arafah, Zine-Eddine Kherraf, Anderson Loundou, Christophe Arnoult, Marie Roberte Guichaoua

Publikováno v: Human Reproduction
Human Reproduction, Oxford University Press (OUP), 2021, 36 (3), pp.693-701. ⟨10.1093/humrep/deaa329⟩
Human Reproduction, 2021, 36 (3), pp.693-701. ⟨10.1093/humrep/deaa329⟩

After the two meiotic divisions, haploid round spermatids undergo dramatic changes to become mature spermatozoa. One of the main transformations consists of compacting the cell nucleus to confer the sperm its remarkable hydrodynamic property and to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8e31c537fd1dac0ce67172ebeb364f
https://hal.archives-ouvertes.fr/hal-02985525

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

Autor: Laurent Abel, Laurie H. Glimcher, Lluis Quintana-Murci, Nico Marr, Fatima Al Ali, Jean Marc Doisne, David Langlais, Jacinta Bustamante, Marc Weisshaar, Jing Han, Jamila El Baghdadi, Frédéric Batteux, Manon Roynard, Yichao Shen, Mathieu Bourgey, Flore Rozenberg, Federica Sallusto, Peng Zhang, David Jarrossay, Carmen Oleaga-Quintas, Jean-Laurent Casanova, Daniela Latorre, Gaspard Kerner, Mahbuba Rahman, Houda Elarabi, Federico Mele, Yoann Seeleuthner, James P. Di Santo, Stuart G. Tangye, Michael S. Kobor, Janet Markle, Dusan Bogunovic, Stéphanie Boisson-Dupuis, Julia L. Maclsaac, Lucas T. Husquin, Lisa Worley, Conor Gruber, Cindy S. Ma, Jérémie Rosain, Taushif Khan, Thomas L. Carroll, Mohamed Jeljeli, Abderrahmane Errami, Anne Puel, Qiang Pan-Hammarström, Philippe Gros, Ibithal Benhsaien, Aziz Bousfiha, Fatima Ailal, Carys A. Croft, Rui Yang, Masato Ogishi

Publikováno v: Cell
Cell, 2020, 183 (7), pp.1826-1847.e31. ⟨10.1016/j.cell.2020.10.046⟩
Cell, Elsevier, 2020, 183 (7), pp.1826-1847.e31. ⟨10.1016/j.cell.2020.10.046⟩

International audience; Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to inherited deficiency of the transcription factor T-bet. The patient has extremely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad4b0b417659433e7af8596ff7bd993
https://hal-pasteur.archives-ouvertes.fr/pasteur-03260339