Výsledky vyhledávání - "MESH: Chlorpromazine"

Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

Autor: Michael Blatzer, Raphaël Gaillard, Gérard Friedlander, Fabien Vinckier, David Attali, Etienne Simon-Loriere, Jeanne Chiaravalli, Anne-Cécile Petit, Laurine Levillayer, Matthieu Prot, Marion Plaze, Fabrice Chrétien, Florent Perin-Dureau, Arnaud Cachia

Publikováno v: International Journal of Antimicrobial Agents
International Journal of Antimicrobial Agents, 2021, 57 (3), pp.106274. ⟨10.1016/j.ijantimicag.2020.106274⟩
International Journal of Antimicrobial Agents, Elsevier, 2021, 57 (3), pp.106274. ⟨10.1016/j.ijantimicag.2020.106274⟩

Highlights • Chlorpromazine, an FDA-approved drug, inhibits clathrin-mediated endocytosis • CPZ acts as an antiviral against SARS-CoV-1 and MERS-CoV • We evidenced antiviral activity of CPZ against SARS-CoV-2 in monkey and human cells • Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f0e3680c968796e70077ea4e2a16c7
https://doi.org/10.1016/j.ijantimicag.2020.106274

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Repurposing chlorpromazine to treat COVID-19: The reCoVery study

Autor: David Attali, Marion Plaze, Michael Blatzer, Anne-Cécile Petit, Raphaël Gaillard, Fabrice Chrétien, Fabien Vinckier, Etienne Simon-Loriere, Arnaud Cachia

Publikováno v: LEncéphale
L'Encephale
L'Encéphale
L'Encéphale, 2020, 46 (3), pp.169-172. ⟨10.1016/j.encep.2020.05.006⟩

International audience; ObjectivesThe ongoing COVID-19 pandemic has caused approximately 2,350,000 infections worldwide and killed more than 160,000 individuals. In Sainte-Anne Hospital (GHU PARIS Psychiatrie & Neuroscience, Paris, France) we have ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498c40b065e904f063e1e5100632c67a

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Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

Autor: Sébastien Anthérieu, Ziad Abdel-Razzak, Pamela Bachour-El Azzi, Julie Dumont, Bernard Fromenty, André Guillouzo, Marie-Anne Robin, Christiane Guguen-Guillouzo

Publikováno v: Hepatology; Vol 57
Hepatology
Hepatology, 2013, 57 (4), pp.1518-29. ⟨10.1002/hep.26160⟩
Hepatology, Wiley-Blackwell, 2013, 57 (4), pp.1518-29. ⟨10.1002/hep.26160⟩

International audience; UNLABELLED: Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872cc99b8d9de10e01aebf4aa0db5131
https://pubmed.ncbi.nlm.nih.gov/23175273

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Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

Autor: Sophie Langouët, Caroline Aninat, Typhen Le Charpentier, Denise Glaise, Amélie Piton, André Guillouzo, Fabrice Morel, Christiane Guguen-Guillouzo

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2006, 34 (1), pp.75-83. ⟨10.1124/dmd.105.006759⟩
Drug Metabolism and Disposition, 2006, 34 (1), pp.75-83. ⟨10.1124/dmd.105.006759⟩

International audience; Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially major cytochrome P450 (P450)-related enzyme activities, making them unrepresentative of in vivo hepatocytes. We have used the Hepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5474bfe7ecff8f5142c8cd01109e32
https://hal.archives-ouvertes.fr/hal-00702085

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Fungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules

Autor: Didier Fournier, Claire Marty-Detraves, Frédéric Francis, Laurent Baricault, Renaud Poincloux, Laurent Paquereau

Publikováno v: European Journal of Cell Biology
European Journal of Cell Biology, Elsevier, 2003, 82 (10), pp.515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dae72390fd628b8ab3098e875a6d457
https://hal.archives-ouvertes.fr/hal-00177744

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Reincorporated plasma membrane Ca2+-ATPase can mediate B-Type Ca2+ channels observed in native membrane of human red blood cells

Autor: Pinet, C., Antoine, S., Filoteo, A.G., Penniston, J.T., Coulombe, A.

Publikováno v: Journal of Membrane Biology
Journal of Membrane Biology, Springer Verlag (Germany), 2002, 187 (3), pp.185-201. ⟨10.1007/s00232-001-0163-5⟩

International audience; Recently, we reported indirect evidence that plasma membrane Ca2+-ATPase (PMCA) can mediate B-type Ca2+ channels of cardiac myocytes. In the present study, in order to bring more direct evidence, purified PMCA from human red b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c6bb0ea6610863acfcecc8a588efa7d
https://hal.inrae.fr/hal-03119300

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Are B-type Ca 2+ Channels of Cardiac Myocytes Akin to the Passive Ion Channel in the Plasma Membrane Ca 2+ Pump?

Autor: Alain Coulombe, C. Pinet, S. Antoine

Publikováno v: Journal of Membrane Biology
Journal of Membrane Biology, Springer Verlag (Germany), 2001, 179 (1), pp.37-50. ⟨10.1007/s002320010035⟩

International audience; The present study demonstrates that B-type Ca2+ channels observed in rat ventricular myocytes markedly reacted to agents known to affect the ion-motive plasma membrane Ca2+-ATPase (PMCA) pump. Chlorpromazine (CPZ)-activated B-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7930ddd19cfc3772de989d14458a0ee
https://hal.inrae.fr/hal-03119303

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