The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Autor: Andrew G. Watts, A. Carlos Frasch, Ricardo Resende, Jean M. H. van den Elsen, Susan J. Crennell, Patricia Marcé, Pedro M. Alzari, Zexin Chen

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩
Chen, Z, Marce Villa, P, Resende, R, Alzari, P M, Frasch, A C, Van Den Elsen, J, Crennell, S & Watts, A 2018, ' The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase ', European Journal of Medicinal Chemistry, vol. 158, pp. 25-33 . https://doi.org/10.1016/j.ejmech.2018.08.089
European Journal of Medicinal Chemistry, 2018, 158, pp.25-33. ⟨10.1016/j.ejmech.2018.08.089⟩

The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ddfe1a4a8535e8f8ad3c5e44d9ceac
https://doi.org/10.1016/j.ejmech.2018.08.089

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Autor: Andrea Medeiros, Francesca Moraca, Marcelo A. Comini, Maurizio Botta, Cecilia Ortíz, Niall M. Hamilton

Publikováno v: Molecules
Molecules, MDPI, 2016, 21 (3), pp.368. ⟨10.3390/molecules21030368⟩
Molecules, Vol 21, Iss 3, p 368 (2016)
Molecules; Volume 21; Issue 3; Pages: 368

International audience; Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate). Based on its indispensabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7187f5e0d7bb2d19af004bec389b80
https://hal-riip.archives-ouvertes.fr/pasteur-01499027/file/molecules-21-00368.pdf

Human Congenital Infection With Trypanosoma cruzi Induces Phenotypic and Functional Modifications of Cord Blood NK Cells

Autor: Aurélie Berthe, Yves Carlier, Faustino Torrico, Veronique M. Braud, Carine Truyens, Emmanuel Hermann, Amilcar Flores, Cristina Alonso-Vega, Lorenzo Moretta, Marisol Cordova

Publikováno v: Pediatric Research
Pediatric Research, Nature Publishing Group, 2006, 60 (1), pp.38-43. ⟨10.1203/01.pdr.0000220335.05588.ea⟩

We studied the phenotype and activity of cord blood natural killer (NK) cells in newborns congenitally infected with Trypanosoma cruzi. We found that the proportion of CD56(bright) NK cells was significantly decreased in cord blood from these newborn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295ca451abc41c4d38db7ddc927670fc
https://doi.org/10.1203/01.pdr.0000220335.05588.ea

International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients

Autor: Janis Ladzins, Gladys Crisante, Ana M. Mejia Jaramillo, Maria I. Jercic, Tatiana Tellez, Alexandre J. DaSilva, Stijn Deborggraeve, Alejandro O. Luquetti, Debbie Nolder, Pilar Zorrilla, Patricio Diosque, Maria Mercedes Monje Rumi, Lúcia Maria da Cunha Galvão, Sergio Sosa Estani, Carlos Robello, Omar Triana Chávez, Faustino Torrico, María Flores, Alejandro G. Schijman, Juan David Ramírez, Néstor Añez, Pedro Yachelini, Mariela Sued, Azzedine Assal, Raul Horacio Lucero, Constança Britto, Inés Zulantay, Gisely Hijar, Christine Aznar, Vincent Veron, Margarita Bisio, Carolina Cura, Ana Maria de Castro, Philippe Büscher, Elsa F. Velazquez, Tomás Duffy, Clara Isabel González, José Eduardo Levi, Frederic Auter, Felipe Guhl, Karla Y. Acosta Viana, Yvonne Qvarnstrom, Graciela Russomando, Liliana Orellana, Zunilda Sanchez Leon

Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 1, p e931 (2011)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2011, 5 (1), pp.e931. ⟨10.1371/journal.pntd.0000931⟩
Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Neglected Tropical Diseases; Vol 5

Background A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological response to treatment are research priorities in the field. The pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8813dc3007a3e7b66e680de2561bf5a5
http://europepmc.org/articles/PMC3019106?pdf=render

[Chagas disease screening in the blood donor population]

Autor: Assal A, Pelletier B, David B, Pierre Tiberghien

Publikováno v: Bulletin de la Société de pathologie exotique
Bulletin de la Société de pathologie exotique, Masson, 2009, 102 (5), pp.291-4
Bulletin de la Société de pathologie exotique, 2009, 102 (5), pp.291-4
Europe PubMed Central

International audience; In May 2007, the French Blood Service (Etablissement français du sang, EFS) introduced systematic screening of at-risk blood donors for anti-Trypanosoma cruzi antibodies. This concerned donors originating from an endemic area

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::740ab0f30bfcdf8a23029d68a05af0a4
https://pubmed.ncbi.nlm.nih.gov/20131422