Heterochromatin and cohesion protection at human centromeres: the final say of a long controversy?

Autor: Javerzat, Jean-Paul, Javerzat, Jean‐Paul

Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2018, 19 (4), ⟨10.15252/embr.201845980⟩

Heterochromatin protein‐1 (HP1) is a key component of heterochromatin. Reminiscent of the cohesin complex which mediates sister‐chromatid cohesion, most HP1 proteins in mammalian cells are displaced from chromosome arms during mitotic entry, wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2489206cf4c8d171b61c03ad790a26
https://doi.org/10.15252/embr.201845980

Heterochromatin maintenance and establishment Lessons from the mouse pericentromere

Autor: Aline V. Probst, Geneviève Almouzni

Publikováno v: Nucleus; Vol 2
Nucleus
Nucleus, European Nuclear Society, 2011, 2 (5), pp.332-8. ⟨10.4161/nucl.2.5.17707⟩
Nucleus, 2011, 2 (5), pp.332-8. ⟨10.4161/nucl.2.5.17707⟩

International audience; Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74881e3d2f24d9be1dd255f46dd7930

RNA interference is essential for cellular quiescence

Autor: Benoit Arcangioli, B. Roche, Robert A. Martienssen

Publikováno v: Science
Science, American Association for the Advancement of Science, 2016, 354 (6313), ⟨10.1126/science.aah5651⟩
Science, 2016, 354 (6313), ⟨10.1126/science.aah5651⟩

International audience; Quiescent cells play a predominant role in most organisms. Here we identify RNA interference (RNAi) as a major requirement for quiescence (G0 phase of the cell cycle) in Schizosaccharomyces pombe RNAi mutants lose viability at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca255fa147a87e380c890223588c726
https://europepmc.org/articles/PMC5858868/

Filling annotation gaps in yeast genomes using genome-wide contact maps

Autor: Gilles Fischer, Martial Marbouty, Gianni Liti, Christophe Zimmer, Hervé Marie-Nelly, Axel Cournac, Romain Koszul

Publikováno v: Bioinformatics
Bioinformatics, 2014, 30 (15), pp.2105-13. ⟨10.1093/bioinformatics/btu162⟩
Bioinformatics, Oxford University Press (OUP), 2014, 30 (15), pp.2105-13. ⟨10.1093/bioinformatics/btu162⟩

Motivations: De novo sequencing of genomes is followed by annotation analyses aiming at identifying functional genomic features such as genes, non-coding RNAs or regulatory sequences, taking advantage of diverse datasets. These steps sometimes fail a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7b4bbf8646c7250eb5442990dae88c

Effect of nuclear architecture on the efficiency of double-strand break repair

Autor: Neta Agmon, Christophe Zimmer, Batia Liefshitz, Martin Kupiec, Emmanuelle Fabre

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2013, 15 (6), pp.694-699. ⟨10.1038/ncb2745⟩
Nature Cell Biology, 2013, 15 (6), pp.694-699. ⟨10.1038/ncb2745⟩

International audience; The most dangerous insults to the genome's integrity are those that break both strands of the DNA. Double-strand breaks can be repaired by homologous recombination; in this conserved mechanism, a global genomic homology search

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe02ba3c99d308dea99231f664ee8c5
https://hal-pasteur.archives-ouvertes.fr/pasteur-02446715