A non-covalent peptide-based strategy for siRNA delivery

Autor: Crombez , Laurence, Divita , Gilles

Publikováno v: Methods in Molecular Biology (Clifton then Totova)
Methods in Molecular Biology (Clifton then Totova), Humana Press (Springer Imprint), 2011, 683, pp.349-60. 〈10.1007/978-1-60761-919-2_25〉
Methods in Molecular Biology
Methods in Molecular Biology, Humana Press/Springer Imprint, 2011, 683, pp.349-60. ⟨10.1007/978-1-60761-919-2_25⟩

International audience; The development of short-interfering RNA (siRNA) has provided great hope for therapeutic targeting of specific genes responsible for pathological disorders. However, the poor cellular uptake of siRNA together with the low perm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::968ab1a71cc0f1370cb77b1fbfb6d65b
https://hal.archives-ouvertes.fr/hal-00649534

A non-covalent peptide-based strategy for ex vivo and in vivo oligonucleotide delivery

Autor: Crombez , Laurence, Morris , May C, Heitz , Frederic, Divita , Gilles

Publikováno v: Methods in Molecular Biology (Clifton then Totova)
Methods in Molecular Biology (Clifton then Totova), Humana Press (Springer Imprint), 2011, 764, pp.59-73. 〈10.1007/978-1-61779-188-8_4〉
Methods in Molecular Biology
Methods in Molecular Biology, Humana Press/Springer Imprint, 2011, 764, pp.59-73. ⟨10.1007/978-1-61779-188-8_4⟩

International audience; The dramatic acceleration in identification of new nucleic acid-based therapeutic molecules such as short interfering RNA (siRNA) and peptide-nucleic acid (PNA) analogues has provided new perspectives for therapeutic targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c13de09dc8fe75a3e3164be7e2b88d97
https://hal.archives-ouvertes.fr/hal-00649536

Small Cell Penetrating Maurocalcine Peptides

Autor: Cathy Poillot, Hicham Bichraoui, Céline Tisseyre, Eloi Bahemberae, Nicolas Andreotti, Jean-Marc Sabatier, Michel Ronjat, Michel De Waard

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2012, 287 (21), pp.17331-42. ⟨10.1074/jbc.M112.360628⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (21), pp.17331-42. ⟨10.1074/jbc.M112.360628⟩

International audience; Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. Although it is a highly competitive cell-penetrating peptide (CPP), its relatively large size of 33 amino ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e3e23e3cc82e49fb965bd373a0e75d
https://www.hal.inserm.fr/inserm-00757307

Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide

Autor: Hubert Vaudry, David Vaudry, Ngoc-Duc Doan, Myriam Létourneau, Nicolas Doucet, David Chatenet, Benjamin Folch, Alain Fournier

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, Elsevier, 2012, 163 (2), pp.256-65. ⟨10.1016/j.jconrel.2012.08.021⟩

International audience; The discovery of cell-penetrating peptide opened up new promising avenues for the non-invasive delivery of non-permeable biomolecules within the intracellular compartment. However, some setbacks such as possible toxic effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba3f2eb9eb1899e2d8542c83d778f21
https://pubmed.ncbi.nlm.nih.gov/22922050