Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Autor: Margaux Sala, Nathalie Allain, Mélanie Moreau, Arnaud Jabouille, Elodie Henriet, Aya Abou-Hammoud, Arnaud Uguen, Sylvaine Di-Tommaso, Cyril Dourthe, Anne-Aurélie Raymond, Jean-William Dupuy, Emilie Gerard, Nathalie Dugot-Senant, Benoit Rousseau, Jean-Phillipe Merlio, Anne Pham-Ledart, Béatrice Vergier, Sophie Tartare-Deckert, Violaine Moreau, Frédéric Saltel

Publikováno v: Oncogene
Oncogene, 2022, 41 (18), pp.2571-2586. ⟨10.1038/s41388-022-02266-1⟩

International audience; Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted therapy is the acqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e902fb034a72453fff297cfa67b184
https://doi.org/10.1038/s41388-022-02266-1

Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

Autor: Cherif, Chaïma, Nguyen, Dang Tan, Paris, Clément, Le, Thi Khanh, Sefiane, Thibaud, Carbuccia, Nadine, Finetti, Pascal, Chaffanet, Max, Kaoutari, Abdessamad El, Vernerey, Julien, Fazli, Ladan, Gleave, Martin, Manai, Mohamed, Barthélémy, Philippe, Birnbaum, Daniel, Bertucci, François, Taïeb, David, Rocchi, Palma

Publikováno v: Oncogene
Oncogene, 2022, 41 (1), pp.125-137. ⟨10.1038/s41388-021-02039-2⟩

International audience; Abstract Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We previously showed that heat shock protein 27 (HSP27) acted as a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a298298ed23e27aa7b5f5510d25e24f
https://hal.science/hal-03599176

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair

Autor: de Krijger, Inge, Föhr, Bastian, Pérez, Santiago Hernández, Vincendeau, Estelle, Serrat, Judit, Thouin, Alexander Marc, Susvirkar, Vivek, Lescale, Chloé, Paniagua, Inés, Hoekman, Liesbeth, Kaur, Simranjeet, Altelaar, Maarten, Deriano, Ludovic, Faesen, Alex C, Jacobs, Jacqueline J L, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 2021, 12 (1), pp.5421. ⟨10.1038/s41467-021-25724-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25724-y⟩

MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it controls DNA repair pathway choice by counteracting DNA end-resection. Here we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0eef28d1f10f82de63f851b152c960
https://hdl.handle.net/21.11116/0000-000A-7D73-921.11116/0000-000A-7D6F-F

Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer

Autor: Foucauld Chamming's, Thomas Guilbert, Virginie Mieulet, Elisabetta Marangoni, Anne Vincent-Salomon, Fatima Mechta-Grigoriou, Yann Kieffer, Fariba Nemati, Camille Garnier, Gilles Renault

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11 (1), pp.4219. ⟨10.1038/s41598-021-83685-0⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal molecular subtype (50% cases). These tumors show a desmoplastic reaction with accumu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebc6698c39c3864f71f7f005ae0bdd1
https://ut3-toulouseinp.hal.science/hal-03778944

Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells

Autor: Daniela Sauma, Alenka Lovy, Galdo Bustos, Ulises Ahumada-Castro, César Cárdenas, Jordi Molgó, Pablo Cruz

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 651, p 651 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (2), pp.651. ⟨10.3390/ijms22020651⟩
Volume 22
Issue 2

International audience; T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00057ddd58e6eda9d9497ab849b334d
https://www.mdpi.com/1422-0067/22/2/651