Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

Autor: Marianne Burbage, Pablo J. Sáez, Deborah Lefevre, Thomas Hoyler, Amal Zine El Aabidine, Rébecca Panes, Guadalupe Suarez, Christel Goudot, Sebastian Amigorena, Jean-Marie Carpier, Mengliang Ye, Fanny Aprahamian, Claire Hivroz, Florence Cammas, Olivier Joffre, Véronique Adoue, Elina Zueva, Jean-Christophe Andrau, Angelique Bellemare-Pelletier, Sylvère Durand, Leonel Joannas, Etienne Gagnon, Maqbool Muhammad Ahmad, Guido Kroemer, Cyril Esnault, Ulf Gehrmann, Sandrine Heurtebise-Chrétien, Nina Burgdorf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩

Significance CD4 T cells are major regulators of immune responses against both self and pathogens. Understanding pathways that govern CD4 T cell differentiation and regulation are thus key for the discovery of new immunoregulatory drug targets. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc87a7d673a9a3997e6fdd23ac6a75
https://hal.archives-ouvertes.fr/hal-02369616/document

Modeling Human Neural Functionality In Vitro: Three-Dimensional Culture for Dopaminergic Differentiation

Autor: Paula M. Alves, André E.P. Bastos, Stefania Piersanti, Ana P. Teixeira, Giampietro Schiavo, Lucy M. Collinson, Daniel Simão, Catarina Brito, Margarida Serra, Sigrid C. Schwarz, Isabella Saggio, Catarina Pinto, Christopher J. Peddie, Eric J. Kremer, Pedro A. Lima, Valerio Licursi, Sara Salinas, Anne Weston

Publikováno v: Tissue Engineering: Parts A, B, and C
Tissue Engineering: Parts A, B, and C, Mary Ann Liebert, 2015, 21 (3-4), pp.654-668. ⟨10.1089/ten.TEA.2014.0079⟩
Tissue Engineering: Parts A, B, and C, 2015, 21 (3-4), pp.654-668. ⟨10.1089/ten.TEA.2014.0079⟩

International audience; Advances in mechanistic knowledge of human neurological disorders have been hindered by the lack of adequate human in vitro models. Three-dimensional (3D) cellular models displaying higher biological relevance are gaining mome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8495e6a6afa4a5eb7eb19b25deb78964
https://doi.org/10.1089/ten.tea.2014.0079

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors

Autor: Nadine Tarantino, Nathalie Aulner, Sara Ortica, Neetu Gupta-Rossi, Alain Israël

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 28 (2), pp.603-614. ⟨10.1096/fj.13-235903⟩
FASEB Journal, 2013, 28 (2), pp.603-614. ⟨10.1096/fj.13-235903⟩

International audience; The Notch signaling pathway is involved in liver development and regeneration. Here, we investigate the role of the 4 mammalian Notch paralogs in the regulation of hepatoblast proliferation and hepatocytic differentiation. Our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf875a7186f39fb05860d6e6455eb2ad
https://hal-pasteur.archives-ouvertes.fr/pasteur-02648728