Výsledky vyhledávání - "MESH: Cell Degranulation"

Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity

Autor: Nicolas Gaudenzio, Thomas Marichal, Stephen J. Galli, Laurent L. Reber

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 2018, 9, pp.1275. ⟨10.3389/fimmu.2018.01275⟩
Frontiers in Immunology, Frontiers, 2018, 9, pp.1275. ⟨10.3389/fimmu.2018.01275⟩

International audience; Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef96c9bd843387b03a512e737d448412
https://doi.org/10.3389/fimmu.2018.01275

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The 'Mast Cell and Basophil Club' of the French Society for Immunology

Autor: Joana Vitte, S. Georgin-Lavialle, Laurent L. Reber, Ulrich Blank, Michel Arock, Nicolas Gaudenzio, Mei Li, Nicolas Charles, Gaël Ménasché

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2020, 50 (10), pp.1430-1431. ⟨10.1002/eji.202070105⟩
European Journal of Immunology, Wiley-VCH Verlag, 2020, 50 (10), pp.1430-1431. ⟨10.1002/eji.202070105⟩

International audience; Mast cells and basophils are best known for their key role during allergic responses [1]. Yet, they also have pivotal functions in innate and acquired (via IgE) defense mechanisms against microbes and parasites as well as in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6508b4692b7a13b3da7e3d38953594
https://doi.org/10.1002/eji.202070105

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Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

Autor: Silvia Pesce, Marco Greppi, Silvia Parolini, Fabio Rampinelli, Emanuela Marcenaro, Lorenzo Moretta, Alessandro Moretta, Daniel Olive, Giovanna Tabellini

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2017, 139 (1), pp.335-346.e3. ⟨10.1016/j.jaci.2016.04.025⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2017, 139 (1), pp.335-346.e3. ⟨10.1016/j.jaci.2016.04.025⟩

Background: PD-1 is an immunological checkpoint that limits immune responses by delivering potent inhibitory signals to T cells upon interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd516a33aa9f174e0a46736d6687db2
http://hdl.handle.net/11567/862446

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Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

Autor: Eric Espinosa, Nicolas Gaudenzio, Régis Joulia, Salvatore Valitutti, Jodie Lopez, Nicolas Blanchard, Magda Rodrigues

Publikováno v: Nature Communications
Nature Communications, 2015, 6, pp.6174. ⟨10.1038/ncomms7174⟩

International audience; Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resultin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf64439b732f4e6af71981bef467c0
https://doi.org/10.1038/ncomms7174

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ASC Controls IFN-γ Levels in an IL-18–Dependent Manner in Caspase-1–Deficient Mice Infected with Francisella novicida

Autor: Roberto Pierini, Irmgard Förster, Thomas Henry, Thierry Walzer, Carole Juruj, Marie-Cécile Michallet, Jacqueline Marvel, Magali Perret, Sophia Djebali

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2013, 191 (7), pp.3847-57. ⟨10.4049/jimmunol.1203326⟩
Journal of Immunology, 2013, 191 (7), pp.3847-57. ⟨10.4049/jimmunol.1203326⟩

Remerciements ECOFECT; International audience; The inflammasome is a signaling platform that is central to the innate immune responses to bacterial infections. Francisella tularensis is a bacterium replicating within the host cytosol. During F. tular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03252b54fe580fd6f7bbc207e3018d8f
https://doi.org/10.4049/jimmunol.1203326

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Different activation signals induce distinct mast cell degranulation strategies

Autor: Thomas Marichal, Eric Espinosa, Ilan Hammel, Stephen J. Galli, Riccardo Sibilano, Salvatore Valitutti, Xinzhong Dong, Mindy Tsai, Benjamin D. McNeil, Nicolas Cenac, Nicolas Gaudenzio, Laurent L. Reber, Joseph D. Hernandez, Ronit Sagi-Eisenberg, Axel Roers, Philipp Starkl

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2016, 126 (10), pp.3981-3998. ⟨10.1172/JCI85538⟩

International audience; Mast cells (MCs) influence intercellular communication during inflammation by secreting cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs decode different activation stimuli into spatiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e6958d18aff4efd88b5a52e9e40efe
https://ut3-toulouseinp.hal.science/hal-03532419

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IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity

Autor: Starkl, Philipp, Marichal, Thomas, Gaudenzio, Nicolas, Reber, Laurent Lionel, Sibilano, Riccardo, Tsai, Mindy, Galli, Stephen Joseph, Reber, Laurent, Galli, Stephen

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2016, 137 (1), pp.246-257.e11. ⟨10.1016/j.jaci.2015.08.005⟩

Background Type 2 cytokine–related immune responses associated with development of antigen-specific IgE antibodies can contribute to pathology in patients with allergic diseases and to fatal anaphylaxis. However, recent findings in mice indicate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e043f2853da5ea6b8faba29a47c1f2
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03431236

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Human CD4+invariant NKT cells are involved in antibacterial immunity againstBrucella suisthrough CD1d-dependent but CD4-independent mechanisms

Autor: Sherri Dudal, Stéphanie Bessoles, Virginie Lafont, Gurdyal S. Besra, Françoise Sanchez

Publikováno v: European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2009, 39 (4), pp.1025-35. ⟨10.1002/eji.200838929⟩

International audience; Human invariant NKT (iNKT) cells are a unique subset of T cells, which recognize glycolipids presented by the CD1d. Among the iNKT cells, several functionally distinct subsets have been characterized according to CD4 and/or CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412a39fb595ad3847691ae118d42c3fc
https://doi.org/10.1002/eji.200838929

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Le neutrophile : une cellule choc

Autor: David A. Mancardi, Marc Daëron, Friederike Jönsson, Pierre Bruhns

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2011, 27 (10), pp.823-825. ⟨10.1051/medsci/20112710010⟩
médecine/sciences, 2011, 27 (10), pp.823-825. ⟨10.1051/medsci/20112710010⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f71aa6d431407acc78175bac3afba9
https://doi.org/10.1051/medsci/20112710010

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