A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus

Autor: Lazorthes, Sandra, Vallot, Céline, Briois, Sébastien, Aguirrebengoa, Marion, Thuret, Jean-Yves, St Laurent, Georges, Rougeulle, Claire, Kapranov, Philipp, Mann, Carl, Trouche, Didier, Nicolas, Estelle

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2015, pp.5971. ⟨10.1038/ncomms6971⟩
Nature Communications, Nature Publishing Group, 2015, pp.5971. 〈10.1038/ncomms6971〉
Nature Communications, 2015, pp.5971. ⟨10.1038/ncomms6971⟩
Nature Communications, Nature Publishing Group, 2015, 6 (1), ⟨10.1038/ncomms6971⟩

Non-coding RNAs (ncRNAs) play major roles in proper chromatin organization and function. Senescence, a strong anti-proliferative process and a major anticancer barrier, is associated with dramatic chromatin reorganization in heterochromatin foci. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c66a7fe49be1e7e2675d6b7bb3b6333
http://europepmc.org/articles/PMC4309439

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

Autor: Annamaria Biroccio, Eric Gilson, Anaïs Poulet, Christelle Lenain, Anna Bizard, Delphine Benarroch, Arturo Londoño-Vallejo, Erica Salvati, Laure Sabatier, Els Verhoeyen, Julia Morere, Jing Ye, Sébastien Britton, Bernard Salles, Yunlin Wu, Angela Maria Rizzo, Marc Nadal, Patrick Calsou, Adelaïde Saint-Léger, Marie Josèphe Giraud-Panis, Frédérique Magdinier, Simon Amiard, Serge Bauwens

Publikováno v: Cell
Cell, 2010, 142 (2), pp.230-242. ⟨10.1016/j.cell.2010.05.032⟩
Cell, Elsevier, 2010, 142 (2), pp.230-242. ⟨10.1016/j.cell.2010.05.032⟩
Cell, Elsevier, 2010, 142 (2), pp.230-42. ⟨10.1016/j.cell.2010.05.032⟩

International audience; Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5' exonuclease activity of its binding partner, Apollo, a member of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b3259112ac3c7f0b1fb27e495f2a67

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

Autor: Aurélie Villaret, Tamara Tchkonia, Patrick Chiotasso, Coralie Sengenès, James L. Kirkland, David Estève, Marie Adeline Marques, Max Lafontan, Pauline Decaunes, Jean Galitzky, Anne Bouloumié

Publikováno v: Diabetes; Vol 59
Diabetes
Diabetes, 2010, 59 (11), pp.2755-63. ⟨10.2337/db10-0398⟩

OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage, susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We defined the properties of endothelial cells (EC) isolated from sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb150f93f744c3cabb48c7ce3a0af72

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Autor: Céline Douarre, Jean-François Riou, Hamid Morjani, Marie-Françoise O'Donohue, Chantal Trentesaux, Patrick Mailliet, Lahcen Eddabra, Dennis Gomez, Jean-Marie Zahm

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2005, 33 (7), pp.2192-2203. ⟨10.1093/nar/gki514⟩
Nucleic Acids Research, Oxford University Press, 2005, 33 (7), pp.2192-203. ⟨10.1093/nar/gki514⟩
Nucleic Acids Research, 2005, 33 (7), pp.2192-203. ⟨10.1093/nar/gki514⟩

International audience; The triazine derivative 12459 is a potent G-quadruplex interacting agent that inhibits telomerase activity. This agent induces time- and dose-dependent telomere shortening, senescence-like growth arrest and apoptosis in the hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd338d868e811dff30e13d8a488e0e1
http://europepmc.org/articles/PMC1079972

Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius

Autor: Catherine Vergely, Laurent Mosoni, Hervé Dubouchaud, Luc Demaison, Eric Fontaine, Jean-Michel Chardigny, A. Oudot, Caroline Martin, Xavier Leverve, C. Keriel, Luc Rochette

Publikováno v: Aging Cell
Aging Cell, Wiley Open Access, 2007, 6 (2), pp.165-77. ⟨10.1111/j.1474-9726.2007.00271.x⟩
Aging Cell, 2007, 6 (2), pp.165-77. ⟨10.1111/j.1474-9726.2007.00271.x⟩
Aging Cell, Wiley Open Access, 2007, 6 (2), pp.165-77. 〈10.1111/j.1474-9726.2007.00271.x〉
Aging Cell 2 (6), 165-77. (2007)

International audience; Aging triggers several abnormalities in muscle glycolytic fibers including increased proteolysis, reactive oxygen species (ROS) production and apoptosis. Since the mitochondria are the main site of substrate oxidation, ROS pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69651bb10cd90f99984854df5a40120d
https://www.hal.inserm.fr/inserm-00388555/document