Výsledky vyhledávání - "MESH: Caspase 3"

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

Autor: Patrick Mehlen, Chantal Thibert, Rémy Sadoul, Joanna Fombonne, Catherine Guix, Pierre-Antoine Bissey

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (26), pp.10510-5. ⟨10.1073/pnas.1200094109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (26), pp.10510-10515. ⟨10.1073/pnas.1200094109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (26), pp.10510-5. ⟨10.1073/pnas.1200094109⟩
Proceedings-National Academy of Sciences Usa
Proceedings-National Academy of Sciences Usa, 2012, 109 (26), pp.10510-5. 〈10.1073/pnas.1200094109〉

International audience; Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c8e0cced55fc3e03d17eca3081016e
https://doi.org/10.1073/pnas.1200094109

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Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells

Autor: André Guillouzo, Camille C Savary, Rozenn Jossé, Ahmad Sharanek

Publikováno v: Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2014, 209, pp.68-76. ⟨10.1016/j.cbi.2013.12.002⟩
Chemico-Biological Interactions, 2014, 209, pp.68-76. ⟨10.1016/j.cbi.2013.12.002⟩

International audience; Isomalathion is a major impurity of technical grade malathion, one of the most abundantly applied insecticides; however little is known about its hepatotoxicity. In the present study, cytotoxicity and genotoxicity of malathion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c708b9da43d44c962d11745cf6d9f9d
https://doi.org/10.1016/j.cbi.2013.12.002

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The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway

Autor: Laurence Desrues, Hubert Vaudry, Jérôme Leprince, Mohamed Amri, David Vaudry, Olfa Masmoudi-Kouki, Hadhemi Kaddour, Yosra Hamdi, Hélène Castel, Marie-Christine Tonon, M. Basille

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2013, 125 (4), pp.620-633. ⟨10.1111/jnc.12140⟩

International audience; Oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays a critical role in neuronal injury. In this study, we have investigated the potential neuropro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc4d8905b8e4847692b514fb67277f0
https://doi.org/10.1111/jnc.12140

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PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action

Autor: Omar Touzani, Alain Fournier, Steve Bourgault, David Vaudry, Hubert Vaudry, Agnieszka Dejda, Tommy Seaborn

Publikováno v: Peptides
Peptides, Elsevier, 2011, 32 (6), pp.1207-16. ⟨10.1016/j.peptides.2011.04.003⟩
Peptides, 2011, 32 (6), pp.1207-16. ⟨10.1016/j.peptides.2011.04.003⟩

International audience; Pituitary adenylate cyclase-activating polypeptide (PACAP) shows potent protective effects in numerous models of neurological insults. However, the use of PACAP as a clinically efficient drug is limited by its poor metabolic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7144f6fad7b1b3e3b96986f423f955e1
https://doi.org/10.1016/j.peptides.2011.04.003

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β-N-methylamino-l-alanine inducedin vivoretinal cell death

Autor: Joëlle Chabry, Nicole Zsürger, Serena Santucci

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2009, 109 (3), pp.819-25. ⟨10.1111/j.1471-4159.2009.06022.x⟩

J. Neurochem. (2009) 109, 819–825. Abstract Controversial debates still remain around the nature of the etiologic agent responsible for Amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC) whose incidence is unusually high among the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14307c1b1c9e5ab88f9c96355008dee2
https://doi.org/10.1111/j.1471-4159.2009.06022.x

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Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

Autor: Anastasia R. Goloudina, Elena Y. Kochetkova, Marc Bardou, Arlette Hammann, Oleg N. Demidov, Sarah Richaud, Carmen Garrido, Olga A. Fedorova, Nickolai A. Barlev, Burhan Uyanik, V Clausse

Publikováno v: Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2016, 7 (4), pp.e2195. 〈http://www.nature.com/cddis/journal/v7/n4/full/cddis201696a.html〉. 〈10.1038/cddis.2016.96〉
Cell Death and Disease, Nature Publishing Group, 2016, 7 (4), pp.e2195. ⟨10.1038/cddis.2016.96⟩

Inactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c549fa132fd556be508b199e05ea66
http://europepmc.org/articles/PMC4855675

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CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension

Autor: William Rostène, Julie Frugier, Françoise Baleux, David Godefroy, Isabelle Célérier, Serge Picaud, Françoise Brignole-Baudouin, Julie Degardin, Jeffrey K. Harrison, Christophe Baudouin, José Sahel, Alexandre Denoyer

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e37873. ⟨10.1371/journal.pone.0037873⟩
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e37873. 〈10.1371/journal.pone.0037873〉
PLoS ONE, Vol 7, Iss 6, p e37873 (2012)
PLoS ONE, 2012, 7 (6), pp.e37873. ⟨10.1371/journal.pone.0037873⟩

International audience; Glaucoma, the most common cause of irreversible blindness, is a neuropathy commonly initiated by pathological ocular hypertension due to unknown mechanisms of trabecular meshwork degeneration. Current antiglaucoma therapy does

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f2117383dc58fb64ab823fe3a14537
https://pubmed.ncbi.nlm.nih.gov/22675496

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Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course

Autor: Junhua Wang, Jing Li, Dominique A. Vuitton, Guodong Lü, Georges Mantion, Xiaomei Lu, Renyong Lin, Chuanshan Zhang, Hao Wen

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2012, 7 (1), pp.e30127. 〈10.1371/journal.pone.0030127〉
PLoS ONE, Public Library of Science, 2012, 7 (1), pp.e30127. ⟨10.1371/journal.pone.0030127⟩
PLoS ONE, Vol 7, Iss 1, p e30127 (2012)

International audience; BACKGROUND: Alveolar echinococcosis (AE) is characterized by the tumor-like growth of Echinococcus (E.) multilocularis. Very little is known on the influence of helminth parasites which develop in the liver on the proliferatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ab1ec2254f248e3c800ec318935c9a
https://hal.archives-ouvertes.fr/hal-00719604

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c-mip down-regulates NF-κB activity and promotes apoptosis in podocytes

Autor: Vincent Audard, Marina Candelier, Laure-Hélène Noël, André Pawlak, Georges Guellaen, Nabila Hamdaoui, Dominique Desvaux, Shao-yu Zhang, Philippe Lang, Djillali Sahali, Qingfeng Fan, Virginie Ory

Publikováno v: American Journal of Pathology
American Journal of Pathology, 2012, 180 (6), pp.2284-92. ⟨10.1016/j.ajpath.2012.02.008⟩
American Journal of Pathology, American Society for Investigative Pathology, 2012, 180 (6), pp.2284-92. ⟨10.1016/j.ajpath.2012.02.008⟩
American Journal of Pathology, American Society for Investigative Pathology, 2012, 180 (6), pp.2284-92. 〈10.1016/j.ajpath.2012.02.008〉

International audience; The mechanisms of podocyte disorders in cases of idiopathic nephrotic syndrome (INS) are complex and remain incompletely elucidated. The abnormal regulation of NF-κB may play a key role in the pathophysiology of these podocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1319d7247f5745cad29e34fcdf5224
https://doi.org/10.1016/j.ajpath.2012.02.008

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