WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Autor: Cristina Beltrami, Owen J. L. Rackham, Costanza Emanueli, Nithya Devapragash, Wei-Ping Yu, Xi-Ming Sun, Stuart A. Cook, Norbert Hubner, Francesco Pesce, Ee Ling Heng, Elisabeth Tan, Aida Moreno-Moral, Enrique Lara-Pezzi, Gianni D Angelini, Enrico Petretto, Huimei Chen, Paul J.R. Barton, Nathan Harmston, Michal Pravenec, Sebastian Schafer, Maxime Rotival, Nicole Tee, Massimilano Mancini, Leanne E. Felkin, Leonardo Bottolo, Prashant K. Srivastava, Kirill Shkura

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Chen, H, Moreno-Moral, A, Pesce, F, Devapragash, N, Mancini, M, Heng, E L, Rotival, M, Srivastava, P K, Harmston, N, Shkura, K, Rackham, O J L, Yu, W P, Sun, X M, Tee, N G Z, Tan, E L S, Barton, P J R, Felkin, L E, Lara-Pezzi, E, Angelini, G, Beltrami, C, Pravenec, M, Schafer, S, Bottolo, L, Hubner, N, Emanueli, C, Cook, S A & Petretto, E 2019, ' WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signalling ', Nature Communications, vol. 10, 3616 . https://doi.org/10.1038/s41467-019-11551-9
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)

Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this netw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9a8eae768aaa77cac0482318b75243
https://doi.org/10.1038/s41467-019-11551-9

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A new titinopathy

Autor: De Cid, Rafael, Ben Yaou, Rabah, Roudaut, Carinne, Charton, Karine, Baulande, Sylvain, Leturcq, France, Romero, Norma Beatriz, Malfatti, Edoardo, Beuvin, Maud, Vihola, Anna, Criqui, Audrey, Nelson, Isabelle, Nectoux, Juliette, Ben Aim, Laurène, Caloustian, Christophe, Olaso, Robert, Udd, Bjarne, Bonne, Gisèle, Eymard, Bruno, Richard, Isabelle

Publikováno v: Neurology
Neurology, American Academy of Neurology, 2015, 85 (24), pp.2126-2135. ⟨10.1212/WNL.0000000000002200⟩
Neurology, 2015, 85 (24), pp.2126-2135. ⟨10.1212/WNL.0000000000002200⟩

International audience; To identify the genetic defects present in 3 families with muscular dystrophy, contractures, and calpain 3 deficiency.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6672bd7a2a3d7b972c368f4372020754
https://hal.archives-ouvertes.fr/hal-02336883

Uniform criteria for diagnosing noncompaction by cMRI and echocardiography are warranted

Autor: Josef Finsterer, Sinda Zarrouk-Mahjoub

Publikováno v: Anatolian Journal of Cardiology
The Anatolian Journal of Cardiology
The Anatolian Journal of Cardiology, 2015, 15 (11), pp.959-960. ⟨10.5152/anatoljcardiol.2015.6659⟩

Isolated ventricular noncompaction is a rare primary genetic cardiomyopathy characterized by persistent embryonic myocardial morphology without any other cardiac anomalies. Arrhythmias are frequently present, including both tachyarrhythmia and conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a778ba823c8b2cd04ff743b47c8fe4
http://europepmc.org/articles/PMC5336956

Arginine butyrate per os protects mdx mice against cardiomyopathy, kyphosis and changes in axonal excitability

Autor: Morgane Roulot, Sara Vianello, Sophie Bouyon, Yves Fromes, Marc Herbin, Catherine Sebrié, Evelyne Benoit, Delphine Boerio, Sabine De La Porte

Publikováno v: Neurobiology of Disease, Vol 71, Iss, Pp 325-333 (2014)
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2014, 71, pp.325-33. ⟨10.1016/j.nbd.2014.08.023⟩
Neurobiology of Disease, 2014, 71, pp.325-33. ⟨10.1016/j.nbd.2014.08.023⟩

International audience; Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by lack of dystrophin, a sub-sarcolemmal protein, which leads to dramatic muscle deterioration. We studied in mdx mice, the effects of oral admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227ec26e1dc46aab3621d3856feb3835
https://pubmed.ncbi.nlm.nih.gov/25167832