Výsledky vyhledávání - "MESH: Binding, Competitive"

The coordinated replication of Vibrio cholerae’s two chromosomes required the acquisition of a unique domain by the RctB initiator

Autor: Fournes, Florian, Niault, Theophile, Czarnecki, Jakub, Tissier-Visconti, Alvise, Mazel, Didier, Val, Marie-Eve

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩
Nucleic Acids Research, Oxford University Press, 2021, 49 (19), pp.11119-11133. ⟨10.1093/nar/gkab903⟩

International audience; Vibrio cholerae, the pathogenic bacterium that causes cholera, has two chromosomes (Chr1, Chr2) that replicate in a well-orchestrated sequence. Chr2 initiation is triggered only after the replication of the crtS site on Chr1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::78989246a70ed6b9797197547822388d
http://europepmc.org/articles/PMC8565311

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The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Autor: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani

Publikováno v: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩

International audience; The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as cholesterol in animals. We found that it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cab00f461442b882b9cc5b78e1a41
https://doi.org/10.1016/j.molbiopara.2018.10.001

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DNA binding specificities of Escherichia coli Cas1–Cas2 integrase drive its recruitment at the CRISPR locus

Autor: Clara, Moch, Michel, Fromant, Sylvain, Blanquet, Pierre, Plateau

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (5), pp.2714-2723. ⟨10.1093/nar/gkw1309⟩

International audience; Prokaryotic adaptive immunity relies on the capture of fragments of invader DNA (protospacers) followed by their recombination at a dedicated acceptor DNA locus. This integrative mechanism, called adaptation, needs both Cas1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7b04918c8d792275773b9db6629f7fc5
https://hal-polytechnique.archives-ouvertes.fr/hal-01961608/document

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Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

Autor: Benjamin E. Willcox, Kouhei Tsumoto, Mitsunori Shiroishi, Marco Colonna, Veronique M. Braud, Katsumi Maenaka, Izumi Kumagai, P. Anton van der Merwe, E. Yvonne Jones, Azure T Makadzange, Yasuo Shirakihara, David S.J. Allan, Sarah Rowland-Jones, Kimie Amano

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2003, 100 (15), pp.8856-61. ⟨10.1073/pnas.1431057100⟩

Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) is expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd83b1c2e0672d9e9d31bd829f7c7b9
https://ora.ox.ac.uk/objects/uuid:5a73b58d-9e21-4563-ad6c-6263c2c5469e

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Phosphoenolpyruvate- and ATP-dependent dihydroxyacetone kinases: covalent substrate-binding and kinetic mechanism

Autor: Philipp Schneider, Ulrich Baumann, Karin Flükiger-Brühwiler, Therese Lüthi Nyffeler, Luis F. Garcia-Alles, Christian Siebold, Hans-Beat Bürgi, Bernhard Erni

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2004, 43 (41), pp.13037-13045. ⟨10.1021/bi048575m⟩

International audience; Dihydroxyacetone (Dha) kinases are a sequence-conserved family of enzymes, which utilize two different phosphoryldonors, ATP in animals, plants, and some bacteria, and a multiphosphoprotein of the phosphoenolpyruvate carbohydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f22d0d2667fdadac30454b5e31bcff
https://doi.org/10.1021/bi048575m

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Conformational Remodeling of Femtomolar Inhibitor−Acetylcholinesterase Complexes in the Crystalline State

Autor: Zoran Radić, Yves Bourne, Palmer Taylor, Pascale Marchot

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2010, 132 (51), pp.18292-300. ⟨10.1021/ja106820e⟩
Journal of the American Chemical Society, 2010, 132 (51), pp.18292-300. ⟨10.1021/ja106820e⟩

International audience; The active center of acetylcholinesterase (AChE), a target site for competitive inhibitors, resides centrosymmetric to the subunit at the base of a deep, narrow gorge lined by aromatic residues. At the gorge entry, a periphera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ae20056508e65c8590ed53e183eb86
https://doi.org/10.1021/ja106820e

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TAF4/4b·TAF12 Displays a Unique Mode of DNA Binding and Is Required for Core Promoter Function of a Subset of Genes

Autor: Michal Sharon, Kfir Gazit, Rivka Dikstein, Gabrielle Mengus, Sandra Moshonov, Rofa Elfakess, Irwin Davidson

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2009, 284 (39), pp.26286-96. ⟨10.1074/jbc.M109.011486⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (39), pp.26286-96. ⟨10.1074/jbc.M109.011486⟩

International audience; The major core promoter-binding factor in polymerase II transcription machinery is TFIID, a complex consisting of TBP, the TATA box-binding protein, and 13 to 14 TBP-associated factors (TAFs). Previously we found that the hist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641793577ab5f93bad7a954d3deadb6d
https://doi.org/10.1074/jbc.m109.011486

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ElrA and AUF1 differentially bind cyclin B2 mRNA

Autor: Xun Guo, Therese Mitchell, Rebecca S. Hartley, Gillian Lyons-Levy, Yann Audic, Francoise Gourronc

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2008, 377 (2), pp.653-7. ⟨10.1016/j.bbrc.2008.10.029⟩
Biochemical and Biophysical Research Communications, 2008, 377 (2), pp.653-7. ⟨10.1016/j.bbrc.2008.10.029⟩

International audience; In Xenopus embryos, maternal cyclins drive the first 12 cell divisions after which several cyclins are terminally degraded, including cyclin B2. Cyclin B2 disappearance is due to transcription-mediated mRNA deadenylation at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051254a46f48fe89ff48bca4ccd6bbc0
https://doi.org/10.1016/j.bbrc.2008.10.029

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Evidence by Site-Directed Mutagenesis That Arginine 203 of Thermolysin and Arginine 717 of Neprilysin (Neutral Endopeptidase) Play Equivalent Critical Roles in Substrate Hydrolysis and Inhibitor Binding

Autor: Emmanuel Ruffet, Marie-Claude Fournie-Zaluski, Bernard P. Roques, Michael J. O’Donohue, Serge Antonczak, Cynthia Marie-Claire, Ann Beaumont

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 1997, 36 (45), pp.13938-45. 〈10.1021/bi9712495〉
Biochemistry, American Chemical Society, 1997, 36 (45), pp.13938-45. ⟨10.1021/bi9712495⟩
Biochemistry, American Chemical Society, 1997, 36 (45), pp.13938-13945
Biochemistry, 1997, 36 (45), pp.13938-45. ⟨10.1021/bi9712495⟩

52 ref. 2 tables 4 graph.; International audience; Neprilysin (neutral endopeptidase-24.11, EC 3.4.24.11) is a mammalian zinc-endopeptidase involved in the degradation of biologically active peptides. Although no atomic structure is available for thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd894f7042a6c547cd5080ccad5879a4
https://doi.org/10.1021/bi9712495

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